| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Talladega Nights: The Ballad of Ricky Bobby | $1,943,887 | - | 403 | - | $4,823 | $1,943,887 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | The Queen | $1,610,141 | - | 347 | - | $4,640 | $1,610,141 | 1 | Pathé | true | false |
| 3 | - | The Black Dahlia | $1,065,953 | - | 331 | - | $3,220 | $1,065,953 | 1 | Entertainment Film Distributors | true | false |
| 4 | 1 | You, Me and Dupree | $1,058,212 | -24.1% | 382 | -28 | $2,770 | $12,771,736 | 4 | United International Pictures | false | false |
| 5 | 2 | Little Man | $1,046,269 | -16.4% | 315 | +1 | $3,321 | $5,751,390 | 3 | Sony Pictures Releasing | false | false |
| 6 | 5 | Little Miss Sunshine | $736,019 | +12.8% | 132 | +18 | $5,575 | $1,936,324 | 2 | 20th Century Fox International | false | false |
| 7 | - | The Night Listener | $590,594 | - | 263 | - | $2,245 | $590,594 | 1 | Icon Film Distribution | true | false |
| 8 | - | DOA: Dead or Alive | $422,689 | - | 220 | - | $1,921 | $422,689 | 1 | United International Pictures | true | false |
| 9 | 4 | The Sentinel | $373,214 | -49% | 221 | -74 | $1,688 | $3,373,332 | 3 | 20th Century Fox International | false | false |
| 10 | 3 | Right at Your Door | $353,608 | -57.1% | 285 | -33 | $1,240 | $1,624,524 | 2 | Lionsgate Films | false | false |
| 11 | 12 | Monster House | $312,448 | -15% | 373 | -37 | $837 | $11,669,237 | 6 | Sony Pictures Releasing | false | false |
| 12 | 8 | Volver | $306,719 | -31.5% | 85 | -2 | $3,608 | $3,923,276 | 4 | Pathé | false | false |
| 13 | 13 | Cars | $284,925 | -15.3% | 349 | -55 | $816 | $30,044,096 | 8 | Buena Vista International | false | false |
| 14 | 9 | Pirates of the Caribbean: Dead Man's Chest | $282,087 | -33.1% | 209 | -73 | $1,349 | $97,283,750 | 11 | Buena Vista International | false | false |
| 15 | 7 | Crank | $232,407 | -52.1% | 151 | -102 | $1,539 | $2,406,249 | 3 | United International Pictures | false | false |
| 16 | 14 | John Tucker Must Die | $190,329 | -35.3% | 155 | -62 | $1,227 | $6,958,765 | 5 | 20th Century Fox International | false | false |
| 17 | 17 | Garfield: A Tail of Two Kitties | $188,103 | -5.9% | 295 | -31 | $637 | $117,601,995 | 9 | 20th Century Fox International | false | false |
| 18 | 15 | Lage Raho Munna Bhai | $185,308 | -34.4% | 37 | -1 | $5,008 | $1,250,239 | 3 | Eros Worldwide | false | false |
| 19 | 6 | The Wicker Man | $153,144 | -71.8% | 167 | -181 | $917 | $3,011,294 | 3 | Lionsgate Films | false | false |
| 20 | - | An Inconvenient Truth | $119,861 | - | 18 | - | $6,658 | $119,861 | 1 | United International Pictures | true | false |
| 21 | 16 | Snakes on a Plane | $69,312 | -72.5% | 81 | -121 | $855 | $7,819,737 | 5 | Entertainment Film Distributors | false | false |
| 22 | 11 | Beerfest | $64,970 | -83.3% | 148 | -152 | $438 | $691,551 | 2 | Warner Bros. | false | false |
| 23 | 18 | Severance | $60,019 | -65.1% | 56 | -61 | $1,071 | $3,136,630 | 4 | Pathé | false | false |
| 24 | 20 | Dil Apna Punjabi | $56,222 | -37% | 9 | -1 | $6,246 | $328,106 | 3 | - | false | false |
| 25 | - | Superman Returns | $46,557 | - | 15 | - | $3,103 | $30,175,754 | 10 | Warner Bros. | false | false |
| 26 | - | Stormbreaker | $45,927 | - | 109 | - | $421 | $12,494,440 | 9 | Entertainment Film Distributors | false | false |
| 27 | - | The Wind that Shakes the Barley | $38,810 | - | 32 | - | $1,212 | $6,899,844 | 13 | Pathé | false | false |
| 28 | - | A Scanner Darkly | $33,939 | - | 31 | - | $1,094 | $1,676,973 | 5 | Warner Bros. | false | false |
| 29 | - | The Ant Bully | $31,341 | - | 66 | - | $474 | $3,598,454 | 7 | Warner Bros. | false | false |
| 30 | - | Over the Hedge | $29,601 | - | 86 | - | $344 | $24,378,103 | 12 | United International Pictures | false | false |
| 31 | - | Kabhi Alvida Naa Kehna | $25,346 | - | 22 | - | $1,152 | $3,843,669 | 6 | Yash Raj Films | false | false |
| 32 | - | Driving Lessons | $18,215 | - | 36 | - | $505 | $92,602 | 2 | Tartan | false | false |
| 33 | 19 | Open Water 2: Adrift | $16,728 | -89.5% | 21 | -183 | $796 | $1,314,500 | 3 | Pathé | false | false |
| 34 | - | Shiva | $14,977 | - | 14 | - | $1,069 | $14,977 | 1 | - | true | false |
| 35 | - | Sillunu Oru Kaadhal | $14,571 | - | 3 | - | $4,857 | $61,356 | 2 | Ayngaran International | false | false |
| 36 | - | Snow Cake | $14,421 | - | 18 | - | $801 | $94,466 | 2 | Momentum Pictures | false | false |
| 37 | - | Pyaar Ke Side Effects | $14,156 | - | 7 | - | $2,022 | $14,156 | 1 | Eros Worldwide | true | false |
| 38 | - | Nacho Libre | $12,969 | - | 31 | - | $418 | $7,236,775 | 6 | United International Pictures | false | false |
| 39 | - | Miami Vice | $11,260 | - | 18 | - | $625 | $13,825,558 | 7 | United International Pictures | false | false |
| 40 | - | Naksha | $9,710 | - | 7 | - | $1,387 | $47,251 | 2 | Venus | false | false |
| 41 | - | Aap Ki Khatir | $8,498 | - | 7 | - | $1,214 | $402,839 | 4 | Venus | false | false |
| 42 | - | Shanghai Dreams | $6,516 | - | 3 | - | $2,172 | $24,592 | 2 | Artificial Eye | false | false |
| 43 | - | My Super Ex-Girlfriend | $5,342 | - | 12 | - | $445 | $5,482,533 | 7 | 20th Century Fox International | false | false |
| 44 | - | The Break-Up | $4,366 | - | 5 | - | $873 | $19,289,594 | 9 | United International Pictures | false | false |
| 45 | - | Angel-A | $3,947 | - | 8 | - | $493 | $363,851 | 8 | Optimum Releasing | false | false |
| 46 | - | Thank You for Smoking | $3,874 | - | 2 | - | $1,937 | $2,103,774 | 14 | 20th Century Fox International | false | false |
| 47 | - | The Da Vinci Code | $3,781 | - | 1 | - | $3,781 | $57,174,056 | 18 | Sony Pictures Releasing | false | false |
| 48 | - | Unconscious | $3,774 | - | 3 | - | $1,258 | $3,774 | 1 | Maiden Voyage Pictures | true | false |
| 49 | - | The Notorious Bettie Page | $3,725 | - | 6 | - | $620 | $293,593 | 7 | Icon Film Distribution | false | false |
| 50 | - | Tideland | $3,471 | - | 4 | - | $867 | $88,680 | 6 | Revolver Entertainment | false | false |
