| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | You, Me and Dupree | $1,393,508 | -37.2% | 410 | -2 | $3,398 | $10,922,345 | 3 | United International Pictures | false | false |
| 2 | 2 | Little Man | $1,251,885 | -39.7% | 314 | +1 | $3,986 | $4,276,320 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Right at Your Door | $823,492 | - | 318 | - | $2,589 | $823,492 | 1 | Lionsgate Films | true | false |
| 4 | 4 | The Sentinel | $731,183 | -38.8% | 295 | -1 | $2,478 | $2,560,147 | 2 | 20th Century Fox International | false | false |
| 5 | - | Little Miss Sunshine | $652,399 | - | 114 | - | $5,722 | $652,399 | 1 | 20th Century Fox International | true | false |
| 6 | 3 | The Wicker Man | $543,337 | -61.2% | 348 | -3 | $1,561 | $2,539,598 | 2 | Lionsgate Films | false | false |
| 7 | 8 | Crank | $485,214 | -43.4% | 253 | -10 | $1,917 | $1,846,346 | 2 | United International Pictures | false | false |
| 8 | 9 | Volver | $447,741 | -40.5% | 87 | - | $5,146 | $3,254,945 | 3 | Pathé | false | false |
| 9 | 6 | Pirates of the Caribbean: Dead Man's Chest | $421,927 | -54.4% | 282 | -52 | $1,496 | $96,007,702 | 10 | Buena Vista International | false | false |
| 10 | - | Pulse | $392,415 | - | 279 | - | $1,406 | $731,708 | 1 | United International Pictures | true | false |
| 11 | - | Beerfest | $389,381 | - | 300 | - | $1,297 | $389,381 | 1 | Warner Bros. | true | false |
| 12 | 7 | Monster House | $367,465 | -58.7% | 410 | -20 | $896 | $11,213,245 | 5 | Sony Pictures Releasing | false | false |
| 13 | 5 | Cars | $336,442 | -63.9% | 404 | -20 | $832 | $29,448,774 | 7 | Buena Vista International | false | false |
| 14 | 12 | John Tucker Must Die | $294,342 | -49.8% | 217 | -43 | $1,356 | $6,609,418 | 4 | 20th Century Fox International | false | false |
| 15 | 15 | Lage Raho Munna Bhai | $282,680 | -36.3% | 38 | - | $7,438 | $901,509 | 2 | Eros Worldwide | false | false |
| 16 | 10 | Snakes on a Plane | $251,877 | -64.1% | 202 | -118 | $1,246 | $7,556,480 | 4 | Entertainment Film Distributors | false | false |
| 17 | 14 | Garfield: A Tail of Two Kitties | $199,946 | -57.8% | 326 | -5 | $613 | $11,459,343 | 8 | 20th Century Fox International | false | false |
| 18 | 13 | Severance | $172,023 | -68.1% | 117 | -159 | $1,470 | $2,956,299 | 3 | Pathé | false | false |
| 19 | 11 | Open Water 2: Adrift | $159,503 | -75.2% | 204 | -123 | $781 | $1,202,753 | 2 | Pathé | false | false |
| 20 | 24 | Dil Apna Punjabi | $89,291 | -10.7% | 10 | - | $8,929 | $234,644 | 2 | - | false | false |
