| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Superman Returns | $2,182,284 | - | 574 | - | $3,801 | $2,994,758 | 1 | Warner Bros. | true | false |
| 2 | 1 | Cars | $2,146,257 | -34.7% | 637 | - | $3,369 | $9,659,761 | 2 | Buena Vista International | false | false |
| 3 | 2 | Lucky Number Slevin | $657,890 | -26% | 294 | -10 | $2,237 | $2,649,531 | 3 | Moviemax | false | false |
| 4 | 3 | Garfield: A Tail of Two Kitties | $327,600 | -45.3% | 267 | -45 | $1,226 | $3,459,861 | 3 | 20th Century Fox International | false | false |
| 5 | - | Thank You for Smoking | $317,777 | - | 168 | - | $1,891 | $317,777 | 1 | Lucky Red | true | false |
| 6 | 4 | The Hills Have Eyes | $287,478 | -37.6% | 224 | -25 | $1,283 | $1,173,794 | 2 | 20th Century Fox International | false | false |
| 7 | 5 | Little Man | $143,400 | -29.1% | 109 | +8 | $1,315 | $492,765 | 2 | Sony Pictures Releasing | false | false |
| 8 | - | As You Like It | $111,244 | - | 111 | - | $1,002 | $111,244 | 1 | Medusa Distribuzione | true | false |
| 9 | - | A Good Woman | $89,940 | - | 68 | - | $1,322 | $89,940 | 1 | 01 Distribution | true | false |
| 10 | - | Quinceañera | $46,394 | - | 23 | - | $2,017 | $46,394 | 1 | Teodora Film | true | false |
| 11 | 6 | Domino | $44,213 | -77.9% | 60 | -179 | $736 | $1,275,082 | 3 | Eagle Pictures | false | false |
| 12 | 8 | The Dark Sea | $39,848 | -29.7% | 29 | -1 | $1,374 | $137,332 | 2 | 01 Distribution | false | false |
| 13 | 9 | Time | $35,613 | -33.4% | 34 | -2 | $1,047 | $138,895 | 2 | Mikado Film | false | false |
| 14 | 7 | C.R.A.Z.Y. | $29,315 | -52.1% | 44 | -36 | $666 | $166,162 | 2 | Istituto Luce | false | false |
| 15 | - | What the Hell Am I Doing Here? | $22,585 | - | 34 | - | $664 | $39,854 | 1 | Istituto Luce | true | false |
| 16 | - | Crossing the Bridge: The Sound of Istanbul | $18,337 | - | 13 | - | $1,410 | $18,337 | 1 | Fandango | true | false |
| 17 | 14 | Volver | $16,635 | -37.5% | 15 | -4 | $1,109 | $8,591,347 | 16 | Warner Bros. | false | false |
| 18 | - | Lettere dal Sahara | $15,258 | - | 6 | - | $2,543 | $15,258 | 1 | Istituto Luce | true | false |
| 19 | 15 | The Da Vinci Code | $14,769 | -43.4% | 15 | -5 | $984 | $36,706,317 | 16 | Sony Pictures Releasing | false | false |
| 20 | - | Forget You Not | $14,052 | - | 20 | - | $702 | $14,052 | 1 | Istituto Luce | true | false |
