| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Cars | $2,532,059 | -28% | 498 | -15 | $5,084 | $20,081,158 | 3 | Buena Vista International | false | false |
| 2 | 3 | Pirates of the Caribbean: Dead Man's Chest | $2,493,971 | -22.4% | 472 | -28 | $5,283 | $87,638,385 | 6 | Buena Vista International | false | false |
| 3 | 1 | Miami Vice | $2,242,560 | -47.3% | 412 | +4 | $5,443 | $8,956,769 | 2 | United International Pictures | false | false |
| 4 | - | Monster House | $1,946,543 | - | 424 | - | $4,590 | $1,946,543 | 1 | Sony Pictures Releasing | true | false |
| 5 | - | Nacho Libre | $1,877,854 | - | 366 | - | $5,130 | $1,877,854 | 1 | United International Pictures | true | false |
| 6 | - | Kabhi Alvida Naa Kehna | $1,415,573 | - | 60 | - | $23,592 | $1,415,573 | 1 | Yash Raj Films | true | false |
| 7 | 4 | The Break-Up | $1,047,861 | -30.2% | 36 | -344 | $29,107 | $16,790,586 | 4 | United International Pictures | false | false |
| 8 | 5 | My Super Ex-Girlfriend | $918,275 | -32.7% | 291 | - | $3,155 | $3,585,853 | 2 | 20th Century Fox International | false | false |
| 9 | - | Lady in the Water | $855,364 | - | 287 | - | $2,980 | $855,364 | 1 | Warner Bros. | true | false |
| 10 | 6 | Superman Returns | $770,036 | -42.1% | 276 | -102 | $2,789 | $28,133,384 | 5 | Warner Bros. | false | false |
| 11 | 9 | Garfield: A Tail of Two Kitties | $600,675 | -13.3% | 343 | +7 | $1,751 | $7,648,399 | 4 | 20th Century Fox International | false | false |
| 12 | 7 | Stormbreaker | $524,317 | -31.8% | 326 | -52 | $1,608 | $10,152,615 | 4 | Entertainment Film Distributors | false | false |
| 13 | 8 | The Ant Bully | $395,604 | -45.8% | 370 | +3 | $1,069 | $2,012,379 | 2 | Warner Bros. | false | false |
| 14 | 10 | Over the Hedge | $289,329 | -23.6% | 274 | -62 | $1,055 | $22,923,656 | 7 | United International Pictures | false | false |
| 15 | 11 | The Wind that Shakes the Barley | $166,420 | -4% | 76 | -15 | $2,189 | $6,087,537 | 8 | Pathé | false | false |
| 16 | 16 | The Notorious Bettie Page | $40,387 | -14.3% | 15 | +1 | $2,692 | $136,398 | 2 | Icon Film Distribution | false | false |
| 17 | 19 | Little Fish | $33,771 | +6.9% | 18 | -1 | $1,876 | $358,950 | 4 | Tartan | false | false |
| 18 | - | Tideland | $32,819 | - | 7 | - | $4,688 | $32,819 | 1 | Revolver Entertainment | true | false |
| 19 | 12 | Omkara | $29,601 | -70.4% | 26 | -4 | $1,138 | $473,000 | 3 | Eros Worldwide | false | false |
| 20 | 15 | Angel-A | $28,800 | -40.9% | 23 | -4 | $1,252 | $291,653 | 3 | Optimum Releasing | false | false |
