| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Miami Vice | $25,195,000 | $25,723,815 | +$528,815 | +2.1% | 3,021 | $25,195,000 | $25,723,815 | 1 | Universal Pictures | - |
| 2 | 2 | - | Pirates of the Caribbean: Dead Man's Chest | $20,492,000 | $20,606,578 | +$114,578 | +0.6% | 3,834 | $358,372,000 | $358,485,761 | 4 | Walt Disney Studios Motion Pictures | - |
| 3 | 3 | - | John Tucker Must Die | $14,075,000 | $14,276,534 | +$201,534 | +1.4% | 2,560 | $14,075,000 | $14,276,534 | 1 | Twentieth Century Fox | - |
| 4 | 4 | - | Monster House | $11,500,000 | $11,663,308 | +$163,308 | +1.4% | 3,553 | $43,872,000 | $44,035,290 | 2 | Sony Pictures Releasing | - |
| 5 | 5 | - | The Ant Bully | $8,145,000 | $8,432,465 | +$287,465 | +3.5% | 3,050 | $8,145,000 | $8,432,465 | 1 | Warner Bros. | - |
| 6 | 7 | +1 | You, Me and Dupree | $7,036,000 | $7,106,280 | +$70,280 | +1% | 2,820 | $59,049,000 | $59,119,020 | 3 | Universal Pictures | - |
| 7 | 6 | -1 | Lady in the Water | $7,005,000 | $7,144,275 | +$139,275 | +2% | 3,235 | $32,064,000 | $32,203,657 | 2 | Warner Bros. | - |
| 8 | 8 | - | Little Man | $5,100,000 | $5,124,245 | +$24,245 | +0.5% | 2,175 | $50,163,000 | $50,187,262 | 3 | Revolution Studios | - |
| 9 | 9 | - | The Devil Wears Prada | $4,775,000 | $4,673,346 | -$101,654 | -2.1% | 1,778 | $106,664,000 | $106,561,887 | 5 | Twentieth Century Fox | - |
| 10 | 11 | +1 | Clerks II | $3,945,000 | $4,008,335 | +$63,335 | +1.6% | 2,150 | $18,473,000 | $18,536,759 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 11 | 12 | +1 | Superman Returns | $3,800,000 | $3,788,228 | -$11,772 | -0.3% | 2,005 | $185,806,000 | $185,794,683 | 5 | Warner Bros. | - |
| 12 | 10 | -2 | My Super Ex-Girlfriend | $3,775,000 | $4,096,933 | +$321,933 | +8.5% | 2,702 | $16,429,000 | $16,751,286 | 2 | Twentieth Century Fox | - |
| 13 | 13 | - | Scoop | $3,003,000 | - | - | - | 538 | $3,003,000 | - | 1 | Focus Features | - |
| 14 | 14 | - | Cars | $2,467,000 | $2,620,756 | +$153,756 | +6.2% | 1,556 | $234,649,000 | $234,802,642 | 8 | Walt Disney Studios Motion Pictures | - |
| 15 | 15 | - | Click | $2,000,000 | $1,922,308 | -$77,692 | -3.9% | 1,326 | $132,508,000 | $132,430,248 | 6 | Revolution Studios | - |
| 16 | 16 | - | An Inconvenient Truth | $773,000 | $742,168 | -$30,832 | -4% | 346 | $20,180,000 | $20,149,280 | 10 | Paramount Classics | - |
| 17 | 18 | +1 | A Scanner Darkly | $454,000 | $473,642 | +$19,642 | +4.3% | 263 | $4,073,000 | $4,091,960 | 4 | Warner Independent Pictures (WIP) | - |
| 18 | 20 | +2 | Little Miss Sunshine | $357,000 | $370,998 | +$13,998 | +3.9% | 7 | $485,000 | $499,012 | 1 | Fox Searchlight Pictures | - |
| 19 | 31 | +12 | Wordplay | $179,000 | $147,763 | -$31,237 | -17.5% | 128 | $2,579,000 | $2,550,572 | 7 | IFC Films | - |
| 20 | 30 | +10 | Strangers with Candy | $173,000 | $168,632 | -$4,368 | -2.5% | 95 | $1,569,000 | $1,564,686 | 5 | THINKFilm | - |
| 21 | 33 | +12 | Who Killed the Electric Car? | $120,000 | $115,845 | -$4,155 | -3.5% | 61 | $734,000 | $729,188 | 5 | Sony Pictures Classics | - |
| 22 | 39 | +17 | Shadowboxer | $74,900 | $75,267 | +$367 | +0.5% | 43 | $225,000 | $220,908 | 2 | Freestyle Releasing | - |
| 23 | 49 | +26 | Gabrielle | $32,200 | $28,344 | -$3,856 | -12% | 6 | $139,000 | $135,184 | 3 | IFC Films | - |
| 24 | 63 | +39 | Once in a Lifetime: The Extraordinary Story of the New York Cosmos | $21,600 | $16,634 | -$4,966 | -23% | 11 | $110,000 | $104,753 | 4 | Miramax | - |
| 25 | 81 | +56 | I Like Killing Flies | $6,100 | $5,487 | -$613 | -10% | 1 | $6,100 | $5,487 | 1 | THINKFilm | - |
| 26 | 82 | +56 | Brothers of the Head | $5,600 | $5,203 | -$397 | -7.1% | 1 | $5,600 | $5,203 | 1 | IFC Films | - |
| 27 | 92 | +65 | Darshan | $3,200 | $3,360 | +$160 | +5% | 1 | $6,100 | $6,321 | 1 | IFC Films | - |
