| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Pirates of the Caribbean: Dead Man's Chest | $35,049,000 | $35,215,201 | +$166,201 | +0.5% | 4,133 | $321,733,000 | $321,899,233 | 3 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Monster House | $23,000,000 | $22,217,226 | -$782,774 | -3.4% | 3,553 | $23,000,000 | $22,217,226 | 1 | Sony Pictures Releasing | - |
| 3 | 3 | - | Lady in the Water | $18,210,000 | $18,044,396 | -$165,604 | -0.9% | 3,235 | $18,210,000 | $18,044,396 | 1 | Warner Bros. | - |
| 4 | 4 | - | You, Me and Dupree | $12,787,000 | $12,767,590 | -$19,410 | -0.2% | 3,137 | $45,318,000 | $45,299,080 | 2 | Universal Pictures | - |
| 5 | 5 | - | Little Man | $11,000,000 | $11,025,108 | +$25,108 | +0.2% | 2,537 | $40,611,000 | $40,636,230 | 2 | Revolution Studios | - |
| 6 | 6 | - | Clerks II | $9,625,000 | $10,061,132 | +$436,132 | +4.5% | 2,150 | $9,625,000 | $10,061,132 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 7 | 7 | - | My Super Ex-Girlfriend | $8,700,000 | $8,603,460 | -$96,540 | -1.1% | 2,702 | $8,700,000 | $8,603,460 | 1 | Twentieth Century Fox | - |
| 8 | 8 | - | Superman Returns | $7,460,000 | $7,375,213 | -$84,787 | -1.1% | 2,826 | $178,427,000 | $178,342,711 | 4 | Warner Bros. | - |
| 9 | 9 | - | The Devil Wears Prada | $7,425,000 | $7,361,991 | -$63,009 | -0.8% | 2,248 | $97,571,000 | $97,508,460 | 4 | Twentieth Century Fox | - |
| 10 | 10 | - | Cars | $4,910,000 | $4,947,198 | +$37,198 | +0.8% | 2,410 | $229,449,000 | $229,485,636 | 7 | Walt Disney Studios Motion Pictures | - |
| 11 | 11 | - | Click | $4,000,000 | $4,035,847 | +$35,847 | +0.9% | 2,312 | $128,189,000 | $128,224,427 | 5 | Revolution Studios | - |
| 12 | 12 | - | An Inconvenient Truth | $1,002,000 | $1,000,372 | -$1,628 | -0.2% | 440 | $18,792,000 | $18,790,273 | 9 | Paramount Classics | - |
| 13 | 13 | - | A Scanner Darkly | $661,000 | $678,030 | +$17,030 | +2.6% | 219 | $3,222,000 | $3,238,799 | 3 | Warner Independent Pictures (WIP) | - |
| 14 | 14 | - | The Lake House | $625,000 | $580,465 | -$44,535 | -7.1% | 603 | $50,662,000 | $50,617,228 | 6 | Warner Bros. | - |
| 15 | 15 | - | Nacho Libre | $505,000 | $502,060 | -$2,940 | -0.6% | 505 | $78,692,000 | $78,689,879 | 6 | Paramount Pictures | - |
| 16 | 17 | +1 | The Break-Up | $380,000 | $446,600 | +$66,600 | +17.5% | 406 | $116,994,000 | $117,060,980 | 8 | Universal Pictures | - |
| 17 | 21 | +4 | Over the Hedge | $371,000 | $361,802 | -$9,198 | -2.5% | 329 | $151,717,000 | $151,707,746 | 10 | DreamWorks | - |
| 18 | 19 | +1 | The Fast and the Furious: Tokyo Drift | $308,000 | $378,675 | +$70,675 | +22.9% | 405 | $60,796,000 | $60,866,515 | 6 | Universal Pictures | - |
| 19 | 25 | +6 | Strangers with Candy | $301,000 | $286,837 | -$14,163 | -4.7% | 107 | $1,261,000 | $1,246,961 | 4 | THINKFilm | - |
| 20 | 26 | +6 | Wordplay | $276,000 | $262,675 | -$13,325 | -4.8% | 154 | $2,281,000 | $2,266,235 | 6 | IFC Films | - |
| 21 | 27 | +6 | Waist Deep | $191,000 | $185,822 | -$5,178 | -2.7% | 175 | $21,194,000 | $21,189,315 | 5 | Rogue Pictures | - |
| 22 | 29 | +7 | Who Killed the Electric Car? | $151,000 | $146,468 | -$4,532 | -3% | 62 | $544,000 | $539,930 | 4 | Sony Pictures Classics | - |
| 23 | 33 | +10 | Shadowboxer | $101,000 | $103,238 | +$2,238 | +2.2% | 22 | $101,000 | $103,238 | 1 | Freestyle Releasing | - |
| 24 | 47 | +23 | Gabrielle | $38,000 | $38,342 | +$342 | +0.9% | 3 | $89,300 | $89,667 | 2 | IFC Films | - |
| 25 | 53 | +28 | Once in a Lifetime: The Extraordinary Story of the New York Cosmos | $27,800 | $27,109 | -$691 | -2.5% | 12 | $75,500 | $74,853 | 3 | Miramax | - |
