| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Pirates of the Caribbean: Dead Man's Chest | $62,186,000 | $62,345,264 | +$159,264 | +0.3% | 4,133 | $258,205,000 | $258,364,766 | 2 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Little Man | $21,700,000 | $21,613,176 | -$86,824 | -0.4% | 2,533 | $21,700,000 | $21,613,176 | 1 | Revolution Studios | - |
| 3 | 3 | - | You, Me and Dupree | $21,338,000 | $21,525,560 | +$187,560 | +0.9% | 3,131 | $21,338,000 | $21,525,560 | 1 | Universal Pictures | - |
| 4 | 4 | - | Superman Returns | $11,620,000 | $12,288,317 | +$668,317 | +5.8% | 3,765 | $163,648,000 | $164,316,103 | 3 | Warner Bros. | - |
| 5 | 5 | - | The Devil Wears Prada | $10,450,000 | $10,386,386 | -$63,614 | -0.6% | 2,810 | $83,554,000 | $83,490,860 | 3 | Twentieth Century Fox | - |
| 6 | 6 | - | Cars | $7,536,000 | $7,840,985 | +$304,985 | +4% | 3,003 | $219,697,000 | $220,001,446 | 6 | Walt Disney Studios Motion Pictures | - |
| 7 | 7 | - | Click | $7,000,000 | $7,261,361 | +$261,361 | +3.7% | 3,296 | $119,702,000 | $119,963,211 | 4 | Revolution Studios | - |
| 8 | 8 | - | The Lake House | $1,570,000 | $1,665,485 | +$95,485 | +6.1% | 1,710 | $48,901,000 | $48,996,220 | 5 | Warner Bros. | - |
| 9 | 9 | - | Nacho Libre | $1,523,000 | $1,615,331 | +$92,331 | +6.1% | 1,501 | $77,140,000 | $77,233,137 | 5 | Paramount Pictures | - |
| 10 | 10 | - | A Scanner Darkly | $1,185,000 | $1,266,427 | +$81,427 | +6.9% | 216 | $1,787,000 | $1,868,905 | 2 | Warner Independent Pictures (WIP) | - |
| 11 | 12 | +1 | An Inconvenient Truth | $1,112,000 | $1,165,480 | +$53,480 | +4.8% | 570 | $16,980,000 | $17,033,435 | 8 | Paramount Classics | - |
| 12 | 11 | -1 | The Fast and the Furious: Tokyo Drift | $1,037,000 | $1,168,360 | +$131,360 | +12.7% | 1,140 | $59,724,000 | $59,855,120 | 5 | Universal Pictures | - |
| 13 | 13 | - | The Da Vinci Code | $900,000 | $900,448 | +$448 | <0.1% | 700 | $214,891,000 | $214,891,691 | 9 | Sony Pictures Releasing | - |
| 14 | 14 | - | The Break-Up | $777,000 | $888,135 | +$111,135 | +14.3% | 797 | $115,984,000 | $116,095,220 | 7 | Universal Pictures | - |
| 15 | 15 | - | Waist Deep | $695,000 | - | - | - | 639 | $20,663,000 | - | 4 | Rogue Pictures | - |
| 16 | 16 | - | A Prairie Home Companion | $625,000 | $683,858 | +$58,858 | +9.4% | 536 | $17,910,000 | $17,968,131 | 6 | Picturehouse | - |
| 17 | 18 | +1 | Over the Hedge | $537,000 | $550,782 | +$13,782 | +2.6% | 538 | $150,885,000 | $150,898,980 | 9 | DreamWorks | - |
| 18 | 20 | +2 | Strangers with Candy | $363,000 | - | - | - | 79 | $792,000 | - | 3 | THINKFilm | - |
| 19 | 23 | +4 | Wordplay | $285,000 | $276,513 | -$8,487 | -3% | 144 | $1,862,000 | $1,851,308 | 5 | IFC Films | - |
| 20 | 25 | +5 | Mission: Impossible III | $197,000 | $201,849 | +$4,849 | +2.5% | 283 | $133,378,000 | $133,382,309 | 11 | Paramount Pictures | - |
| 21 | 28 | +7 | Who Killed the Electric Car? | $121,000 | $124,499 | +$3,499 | +2.9% | 48 | $323,000 | $326,436 | 3 | Sony Pictures Classics | - |
| 22 | 40 | +18 | Scary Movie 4 | $58,900 | $53,262 | -$5,638 | -9.6% | 120 | $90,618,000 | $90,612,358 | 14 | Dimension Films | - |
| 23 | 47 | +24 | Gabrielle | $31,100 | $30,676 | -$424 | -1.4% | 2 | $31,100 | $30,676 | 1 | IFC Films | - |
| 24 | 56 | +32 | Once in a Lifetime: The Extraordinary Story of the New York Cosmos | $19,800 | $19,842 | +$42 | +0.2% | 5 | $36,900 | $36,922 | 2 | Miramax | - |
| 25 | 108 | +83 | Lucky Number Slevin | $1,300 | $1,402 | +$102 | +7.8% | 5 | $22,490,000 | $22,494,487 | 15 | Metro-Goldwyn-Mayer (MGM) | - |
