| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Da Vinci Code | $17,643,366 | - | 523 | - | $33,734 | $17,643,366 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Mission: Impossible III | $3,434,011 | -34.1% | 465 | -46 | $7,384 | $23,686,089 | 3 | United International Pictures | false | false |
| 3 | 2 | Prime | $1,048,805 | -34.9% | 383 | - | $2,738 | $3,420,603 | 2 | Momentum Pictures | false | false |
| 4 | 4 | Ice Age: The Meltdown | $854,439 | +1.1% | 420 | -28 | $2,034 | $54,395,319 | 7 | 20th Century Fox International | false | false |
| 5 | - | Waiting... | $572,374 | - | 238 | - | $2,404 | $572,374 | 1 | Momentum Pictures | true | false |
| 6 | 3 | When a Stranger Calls | $539,299 | -42.4% | 281 | -23 | $1,919 | $1,906,020 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | Confetti | $392,415 | -51.8% | 249 | -51 | $1,575 | $3,444,730 | 3 | 20th Century Fox International | false | false |
| 8 | 8 | Brick | $222,874 | -17.6% | 49 | +6 | $4,548 | $655,245 | 2 | Optimum Releasing | false | false |
| 9 | 7 | 16 Blocks | $136,739 | -65.9% | 122 | -141 | $1,120 | $4,121,160 | 4 | Warner Bros. | false | false |
| 10 | 6 | Silent Hill | $133,704 | -69.6% | 129 | -156 | $1,036 | $6,647,346 | 5 | Pathé | false | false |
| 11 | 9 | She's the Man | $104,683 | -45.2% | 125 | -72 | $837 | $8,548,040 | 7 | Entertainment Film Distributors | false | false |
| 12 | 16 | The Shaggy Dog | $93,798 | +36.2% | 108 | -21 | $868 | $5,462,748 | 8 | Buena Vista International | false | false |
| 13 | 13 | 36 China Town | $67,873 | -41.1% | 27 | -7 | $2,513 | $478,294 | 3 | - | false | false |
| 14 | - | The King | $62,330 | - | 28 | - | $2,226 | $62,330 | 1 | Tartan | true | false |
| 15 | 12 | Inside Man | $52,998 | -58.9% | 21 | -60 | $2,523 | $15,234,638 | 9 | United International Pictures | false | false |
| 16 | 15 | Eight Below | $45,884 | -45.9% | 91 | -91 | $504 | $2,075,360 | 5 | Buena Vista International | false | false |
| 17 | 17 | The Squid and the Whale | $40,541 | -22% | 18 | -6 | $2,252 | $1,126,892 | 7 | Sony Pictures Releasing | false | false |
| 18 | 20 | Yours, Mine & Ours | $35,467 | -5.1% | 66 | -12 | $537 | $2,521,505 | 8 | Sony Pictures Releasing | false | false |
| 19 | 10 | Scary Movie 4 | $31,410 | -82% | 52 | -125 | $604 | $11,000,596 | 6 | Buena Vista International | false | false |
| 20 | - | Once in a Lifetime: The Extraordinary Story of the New York Cosmos | $26,211 | - | 22 | - | $1,191 | $26,211 | 1 | Pathé | true | false |
| 21 | 19 | Time to Leave | $20,389 | -56.3% | 10 | -6 | $2,038 | $98,594 | 2 | Artificial Eye | false | false |
| 22 | 22 | Enron: The Smartest Guys in the Room | $16,160 | -28.7% | 7 | -2 | $2,308 | $171,336 | 4 | Lionsgate Films | false | false |
| 23 | 11 | American Dreamz | $13,475 | -90.3% | 2 | -177 | $6,737 | $4,130,507 | 5 | United International Pictures | false | false |
| 24 | 38 | Fateless | $13,073 | +39.2% | 5 | +2 | $2,614 | $48,611 | 3 | Periscoop Film | false | false |
| 25 | - | Pierrepoint: The Last Hangman | $12,973 | - | 9 | - | $1,441 | $374,574 | 7 | Lionsgate Films | false | false |
| 26 | 26 | Tom, Dick, and Harry | $12,244 | -29.2% | 7 | -1 | $1,749 | $42,204 | 2 | Venus | false | false |
| 27 | - | Ankahee | $11,062 | - | 4 | - | $2,765 | $11,062 | 1 | Venus | true | false |
| 28 | - | V for Vendetta | $9,585 | - | 5 | - | $1,917 | $6,722,165 | - | Warner Bros. | - | false |
| 29 | 18 | Take the Lead | $9,530 | -80.8% | 21 | -46 | $453 | $4,240,032 | 7 | Entertainment Film Distributors | false | false |
| 30 | 25 | Walk the Line | $9,248 | -54.9% | 14 | -12 | $660 | $19,049,226 | 16 | 20th Century Fox International | false | false |
| 31 | 14 | Slither | $9,075 | -92% | 31 | -132 | $292 | $2,179,983 | 4 | Entertainment Film Distributors | false | false |
| 32 | - | Caché | $8,419 | - | 5 | - | $1,683 | $2,662,742 | 17 | Artificial Eye | false | false |
| 33 | 24 | The Three Burials of Melquiades Estrada | $7,794 | -62.8% | 8 | -3 | $974 | $720,752 | 8 | Optimum Releasing | false | false |
| 34 | 39 | Ballets Russes | $7,750 | -16.5% | 6 | - | $1,291 | $149,673 | 5 | Revolver Entertainment | false | false |
| 35 | 41 | Paradise Now | $7,298 | -14.1% | 6 | -1 | $1,216 | $342,540 | 6 | Warner Bros. | false | false |
| 36 | - | The World's Fastest Indian | $7,219 | - | 7 | - | $1,031 | $840,237 | 11 | Icon Film Distribution | false | false |
| 37 | 29 | Junebug | $7,081 | -55.8% | 5 | -6 | $1,416 | $381,710 | 6 | Miracle Films | false | false |
| 38 | 27 | Transamerica | $6,933 | -57.6% | 6 | -11 | $1,155 | $1,375,335 | 9 | Pathé | false | false |
| 39 | - | C.R.A.Z.Y. | $6,768 | - | 6 | - | $1,128 | $175,862 | 5 | Soda Pictures | false | false |
| 40 | 35 | The Mistress of Spices | $6,653 | -41.2% | 15 | +1 | $443 | $465,948 | 5 | Entertainment Film Distributors | false | false |
| 41 | 36 | Capote | $6,033 | -37.4% | 3 | -13 | $2,011 | $2,854,497 | 13 | Sony Pictures Releasing | false | false |
| 42 | 42 | Romance & Cigarettes | $5,584 | -33.8% | 7 | -5 | $797 | $422,533 | 9 | Icon Film Distribution | false | false |
| 43 | 49 | U-Carmen eKhayelitsha | $5,268 | -14.1% | 6 | -1 | $878 | $106,313 | 5 | Tartan | false | false |
| 44 | 21 | An American Haunting | $5,230 | -85.6% | 12 | -42 | $435 | $3,394,905 | 6 | Lionsgate Films | false | false |
| 45 | 47 | Wal-Mart: The High Cost of Low Price | $5,230 | -22.8% | 2 | -2 | $2,615 | $17,343 | 2 | Tartan | false | false |
| 46 | 31 | The Devil and Daniel Johnston | $4,499 | -65.1% | 6 | -4 | $749 | $77,963 | 3 | Tartan | false | false |
| 47 | - | Good Night, and Good Luck. | $4,080 | - | 5 | - | $816 | $4,393,941 | 14 | Redbus Film Distribution | false | false |
| 48 | 37 | Syriana | $3,915 | -58.4% | 4 | -9 | $978 | $7,162,144 | 12 | Warner Bros. | false | false |
| 49 | 48 | Failure to Launch | $3,823 | -42.1% | 1 | -6 | $3,823 | $5,546,106 | 8 | United International Pictures | false | false |
