| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Ice Age 2: The Meltdown | $34,500,000 | $33,823,894 | -$676,106 | -2% | 3,969 | $116,428,000 | $115,751,973 | 2 | Twentieth Century Fox | - |
| 2 | 2 | - | The Benchwarmers | $20,500,000 | $19,656,429 | -$843,571 | -4.1% | 3,274 | $20,500,000 | $19,656,429 | 1 | Revolution Studios | - |
| 3 | 3 | - | Take the Lead | $12,775,000 | - | - | - | 3,009 | $12,775,000 | - | 1 | New Line Cinema | - |
| 4 | 4 | - | Inside Man | $9,174,000 | $9,131,410 | -$42,590 | -0.5% | 2,867 | $66,056,000 | $66,013,040 | 3 | Universal Pictures | - |
| 5 | 5 | - | Lucky Number Slevin | $7,130,000 | $7,031,921 | -$98,079 | -1.4% | 1,984 | $7,130,000 | $7,031,921 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 6 | 6 | - | Failure to Launch | $4,107,000 | $4,130,869 | +$23,869 | +0.6% | 2,616 | $79,121,000 | $79,145,215 | 5 | Paramount Pictures | - |
| 7 | 7 | - | ATL | $3,750,000 | $3,710,215 | -$39,785 | -1.1% | 1,602 | $17,255,000 | $17,215,267 | 2 | Warner Bros. | - |
| 8 | 8 | - | V for Vendetta | $3,365,000 | $3,404,210 | +$39,210 | +1.2% | 2,003 | $62,257,000 | $62,296,435 | 4 | Warner Bros. | - |
| 9 | 9 | - | Phat Girlz | $3,100,000 | $3,109,924 | +$9,924 | +0.3% | 1,060 | $3,100,000 | $3,109,924 | 1 | Fox Searchlight Pictures | - |
| 10 | 10 | - | Thank You for Smoking | $2,400,000 | $2,309,097 | -$90,903 | -3.8% | 299 | $6,284,000 | $6,193,074 | 4 | Fox Searchlight Pictures | - |
| 11 | 11 | - | Stay Alive | $2,156,000 | $2,244,848 | +$88,848 | +4.1% | 1,845 | $20,440,000 | $20,528,639 | 3 | Walt Disney Studios Motion Pictures | - |
| 12 | 12 | - | She's the Man | $2,149,000 | $2,209,470 | +$60,470 | +2.8% | 2,026 | $29,790,000 | $29,850,290 | 4 | DreamWorks | - |
| 13 | 13 | - | Slither | $1,528,000 | $1,634,595 | +$106,595 | +7% | 1,946 | $6,478,000 | $6,585,330 | 2 | Universal Pictures | - |
| 14 | 14 | - | Larry the Cable Guy: Health Inspector | $1,475,000 | $1,535,134 | +$60,134 | +4.1% | 1,452 | $13,657,000 | $13,717,136 | 3 | Lionsgate | - |
| 15 | 15 | - | The Shaggy Dog | $1,170,000 | $1,207,878 | +$37,878 | +3.2% | 1,701 | $55,669,000 | $55,706,760 | 5 | Walt Disney Studios Motion Pictures | - |
| 16 | 16 | - | Basic Instinct 2 | $1,000,000 | $1,017,607 | +$17,607 | +1.8% | 1,453 | $5,208,000 | $5,225,676 | 2 | Sony Pictures Releasing | - |
| 17 | 17 | - | The Hills Have Eyes | $675,000 | $692,057 | +$17,057 | +2.5% | 693 | $40,307,000 | $40,324,340 | 5 | Fox Searchlight Pictures | - |
| 18 | 18 | - | Friends with Money | $637,000 | - | - | - | 28 | $637,000 | - | 1 | Sony Pictures Classics | - |
| 19 | 21 | +2 | Tsotsi | $233,000 | $252,380 | +$19,380 | +8.3% | 122 | $1,983,000 | $2,002,279 | 7 | Miramax | - |
| 20 | 24 | +4 | Brick | $196,000 | $199,286 | +$3,286 | +1.7% | 21 | $314,000 | $316,548 | 2 | Focus Features | - |
| 21 | 30 | +9 | When Do We Eat? | $147,000 | $134,006 | -$12,994 | -8.8% | 48 | $147,000 | $134,006 | 1 | THINKFilm | - |
| 22 | 34 | +12 | Madea's Family Reunion | $112,000 | $115,059 | +$3,059 | +2.7% | 193 | $63,038,000 | $63,040,852 | 7 | Lionsgate | - |
| 23 | 37 | +14 | The Three Burials of Melquiades Estrada | $103,000 | $81,534 | -$21,466 | -20.8% | 112 | $4,732,000 | $4,711,247 | 17 | Sony Pictures Classics | - |
| 24 | 35 | +11 | Final Destination 3 | $91,000 | $103,882 | +$12,882 | +14.2% | 167 | $53,939,000 | $53,951,647 | 9 | New Line Cinema | - |
| 25 | 39 | +14 | Mrs. Henderson Presents | $83,800 | $77,200 | -$6,600 | -7.9% | 109 | $10,764,000 | $10,757,195 | 18 | The Weinstein Company | - |
| 26 | 41 | +15 | Neil Young: Heart of Gold | $63,000 | $67,564 | +$4,564 | +7.2% | 60 | $1,510,000 | $1,515,356 | 9 | Paramount Classics | - |
| 27 | 47 | +20 | Brokeback Mountain | $49,200 | $49,193 | -$7 | <0.1% | 104 | $82,970,000 | $82,970,165 | 18 | Focus Features | - |
| 28 | 55 | +27 | The Child | $35,800 | $33,483 | -$2,317 | -6.5% | 16 | $143,000 | $141,073 | 3 | Sony Pictures Classics | - |
| 29 | 58 | +29 | The Devil and Daniel Johnston | $33,000 | $30,757 | -$2,243 | -6.8% | 12 | $68,600 | $66,339 | 2 | Sony Pictures Classics | - |
| 30 | 57 | +27 | Transamerica | $31,100 | $31,102 | +$2 | <0.1% | 59 | $8,780,000 | $8,780,273 | 19 | The Weinstein Company | - |
| 31 | 63 | +32 | C.S.A.: The Confederate States of America | $25,900 | $23,786 | -$2,114 | -8.2% | 22 | $501,000 | $499,107 | 27 | IFC Films | - |
| 32 | 62 | +30 | Ask the Dust | $24,000 | $25,215 | +$1,215 | +5.1% | 46 | $683,000 | $683,769 | 5 | Paramount Classics | - |
| 33 | 61 | +28 | Drawing Restraint 9 | $23,800 | $25,266 | +$1,466 | +6.2% | 3 | $65,400 | $66,642 | 2 | IFC Films | - |
| 34 | 65 | +31 | The Libertine | $22,300 | $21,459 | -$841 | -3.8% | 43 | $4,810,000 | $4,808,748 | 20 | The Weinstein Company | - |
| 35 | 69 | +34 | On a Clear Day | $19,200 | $17,303 | -$1,897 | -9.9% | 5 | $19,200 | $17,303 | 1 | Focus Features | - |
| 36 | 73 | +37 | Hoodwinked! | $13,600 | $13,306 | -$294 | -2.2% | 43 | $51,054,000 | $51,053,787 | 17 | The Weinstein Company | - |
| 37 | 78 | +41 | I Am a Sex Addict | $9,800 | $10,691 | +$891 | +9.1% | 2 | $14,100 | $14,987 | 1 | IFC Films | - |
