| Rank | LW | Release
| Distributor
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | New This Week
| Estimated
|
|---|
| 1 | - | Ice Age: The Meltdown | 20th Century Fox International | $17,025,381 | - | 502 | - | $33,915 | $17,025,381 | 1 | false | false |
| 2 | - | She's the Man | Entertainment Film Distributors | $1,731,634 | - | 305 | - | $5,677 | $1,731,634 | 1 | false | false |
| 3 | - | Alien Autopsy | Warner Bros. | $1,386,484 | - | 417 | - | $3,324 | $1,386,484 | 1 | false | false |
| 4 | 1 | Inside Man | United International Pictures (UIP) | $1,379,258 | -28.9% | 333 | -23 | $4,141 | $9,036,237 | 3 | false | false |
| 5 | 2 | Failure to Launch | United International Pictures (UIP) | $804,761 | -57.2% | 353 | +1 | $2,279 | $3,619,394 | 2 | false | false |
| 6 | 4 | Hostel | Sony Pictures Releasing | $684,051 | -48.3% | 274 | -29 | $2,496 | $6,195,028 | 3 | false | false |
| 7 | 3 | The Shaggy Dog | Buena Vista International | $484,963 | -66.4% | 418 | +1 | $1,160 | $270,564 | 2 | false | false |
| 8 | - | The Dark | Momentum Pictures | $461,658 | - | 191 | - | $2,417 | $461,658 | 1 | false | false |
| 9 | 5 | The Pink Panther | 20th Century Fox International | $442,203 | -57% | 349 | -52 | $1,267 | $9,194,079 | 4 | false | false |
| 10 | 6 | Basic Instinct 2 | Entertainment Film Distributors | $380,825 | -55% | 270 | -20 | $1,410 | $1,632,973 | 2 | false | false |
| 11 | 7 | Firewall | Warner Bros. | $380,317 | -53% | 265 | -16 | $1,435 | $1,663,622 | 2 | false | false |
| 12 | 9 | Yours, Mine & Ours | Sony Pictures Releasing | $301,733 | -47.5% | 265 | +13 | $1,138 | $1,663,622 | 2 | false | false |
| 13 | 8 | The Ringer | 20th Century Fox International | $232,839 | -64.6% | 158 | -98 | $1,473 | $2,828,523 | 3 | false | false |
| 14 | 10 | V for Vendetta | Warner Bros. | $175,585 | -65.1% | 94 | -183 | $1,867 | $5,801,628 | 4 | false | false |
| 15 | - | The Squid and the Whale | Sony Pictures Releasing | $124,004 | - | 17 | - | $7,294 | $124,004 | 1 | false | false |
| 16 | 13 | Transamerica | Pathé | $117,038 | -33.5% | 38 | -4 | $3,079 | $829,720 | 3 | false | false |
| 17 | 15 | Three Burials | Optimum Releasing | $86,914 | -39.4% | 29 | - | $2,997 | $323,485 | 2 | false | false |
| 18 | - | Shaadi Se Pehle | - | $82,530 | - | 19 | - | $4,343 | $82,530 | 1 | false | false |
| 19 | 12 | Walk the Line | 20th Century Fox International | $75,423 | -57.9% | 57 | -83 | $1,323 | $17,196,358 | 10 | false | false |
| 20 | 14 | Syriana | Warner Bros. | $69,410 | -55.1% | 36 | -79 | $1,928 | $6,349,476 | 6 | false | false |
| 21 | 16 | The White Countess | Sony Pictures Releasing | $50,373 | -58.6% | 57 | +5 | $883 | $269,858 | 2 | false | false |
| 22 | 17 | Tsotsi | Momentum Pictures | $50,073 | -47.6% | 25 | -44 | $2,002 | $1,136,250 | 4 | false | false |
| 23 | - | Rent | Sony Pictures Releasing | $44,035 | - | 61 | - | $721 | $44,035 | 1 | false | false |
| 24 | 11 | The Hills Have Eyes | 20th Century Fox International | $40,996 | -78.5% | 46 | -121 | $891 | $6,167,301 | 5 | false | false |
| 25 | - | Saawan... The Love Season | Eros International | $35,171 | - | 17 | - | $2,068 | $35,171 | 1 | false | false |
| 26 | - | Capote | Sony Pictures Releasing | $31,679 | - | 26 | - | $1,218 | $2,379,366 | 7 | false | false |
| 27 | 18 | Chicken Little | Buena Vista International | $29,523 | -61.7% | 138 | -160 | $213 | $23,434,166 | 9 | false | false |
| 28 | - | Deep Sea | IMAX | $29,195 | - | 1 | - | $29,195 | $213,084 | 6 | false | false |
| 29 | 19 | Beyond the Gates 2006 Re-release | - | $28,870 | -53.2% | 18 | -2 | $1,603 | $134,927 | 2 | false | false |
| 30 | 20 | Romance & Cigarettes | Icon Film Distribution | $23,628 | -54.3% | 18 | -9 | $1,312 | $292,053 | 3 | false | false |
| 31 | - | Good Night, and Good Luck. | Redbus Film Distribution | $18,513 | - | 12 | - | $1,542 | $3,928,211 | 8 | false | false |
| 32 | - | Memoirs of a Geisha | Buena Vista International | $16,773 | - | 7 | - | $2,396 | $12,355,989 | 13 | false | false |
| 33 | - | Malamaal Weekly | - | $16,116 | - | 14 | - | $1,151 | $549,397 | 5 | false | false |
| 34 | - | Brokeback Mountain | Entertainment Film Distributors | $13,847 | - | 9 | - | $1,538 | $17,498,549 | 14 | false | false |
| 35 | - | The Proposition | Tartan | $13,800 | - | 8 | - | $1,725 | $1,095,145 | 5 | false | false |
| 36 | - | Caché | Artificial Eye | $12,463 | - | 7 | - | $1,780 | $2,355,293 | 11 | false | false |
| 37 | - | Big Momma's House 2 | 20th Century Fox International | $12,335 | - | 50 | - | $246 | $16,000,690 | 9 | false | false |
| 38 | - | The Constant Gardener | United International Pictures (UIP) | $10,284 | - | 10 | - | $1,028 | $10,834,208 | 22 | false | false |
| 39 | - | The World's Fastest Indian | Icon Film Distribution | $9,114 | - | 18 | - | $506 | $654,688 | 5 | false | false |
| 40 | - | March of the Penguins | Warner Bros. | $7,274 | - | 14 | - | $519 | $5,312,142 | 18 | false | false |
| 41 | - | Lucky Number Slevin | Entertainment Film Distributors | $6,964 | - | 8 | - | $870 | $7,956,571 | 7 | false | false |
| 42 | - | Kidulthood | Revolver Entertainment | $6,663 | - | 10 | - | $666 | $767,196 | 6 | false | false |
| 43 | - | Date Movie | 20th Century Fox International | $5,745 | - | 17 | - | $337 | $8,675,472 | 7 | false | false |
| 44 | - | New York Doll | Optimum Releasing | $5,162 | - | 2 | - | $2,581 | $5,162 | 1 | false | false |
| 45 | - | Unknown White Male | - | $4,420 | - | 1 | - | $4,420 | $4,420 | 1 | false | false |
| 46 | - | The Ballad of Jack and Rose | Entertainment Film Distributors | $4,366 | - | 3 | - | $1,455 | $19,044 | 2 | false | false |
| 47 | - | The Child | Artificial Eye | $4,307 | - | 3 | - | $1,435 | $176,430 | 5 | false | false |
| 48 | - | Munich | United International Pictures (UIP) | $4,225 | - | 3 | - | $1,408 | $8,570,526 | 11 | false | false |
| 49 | - | The Weather Man | Momentum Pictures | $3,495 | - | 1 | - | $3,495 | $1,947,395 | 6 | false | false |
