| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Mr. & Mrs. Smith | $51,100,000 | $50,342,878 | -$757,122 | -1.5% | 3,424 | $51,100,000 | $50,342,878 | 1 | Twentieth Century Fox | - |
| 2 | 2 | - | Madagascar | $17,100,000 | $17,180,801 | +$80,801 | +0.5% | 3,929 | $128,300,000 | $128,414,334 | 3 | DreamWorks Distribution | - |
| 3 | 3 | - | Star Wars: Episode III - Revenge of the Sith | $14,900,000 | $14,851,474 | -$48,526 | -0.3% | 3,322 | $332,100,000 | $332,109,171 | 4 | Twentieth Century Fox | - |
| 4 | 4 | - | The Longest Yard | $13,500,000 | $13,878,482 | +$378,482 | +2.8% | 3,654 | $118,100,000 | $118,484,565 | 3 | Paramount Pictures | - |
| 5 | 5 | - | The Adventures of Sharkboy and Lavagirl 3-D | $12,500,000 | - | - | - | 2,655 | $12,500,000 | - | 1 | Dimension Films | - |
| 6 | 6 | - | Cinderella Man | $9,500,000 | $9,728,955 | +$228,955 | +2.4% | 2,820 | $34,500,000 | $34,642,020 | 2 | Universal Pictures | - |
| 7 | 8 | +1 | The Honeymooners | $5,800,000 | $5,538,835 | -$261,165 | -4.5% | 1,912 | $5,800,000 | $5,538,835 | 1 | Paramount Pictures | - |
| 8 | 7 | -1 | The Sisterhood of the Traveling Pants | $5,700,000 | $5,711,420 | +$11,420 | +0.2% | 2,583 | $23,700,000 | $23,732,629 | 2 | Warner Bros. | - |
| 9 | 9 | - | Monster-in-Law | $2,600,000 | - | - | - | 1,949 | $76,500,000 | - | 5 | New Line Cinema | - |
| 10 | 11 | +1 | Crash | $1,900,000 | $1,876,639 | -$23,361 | -1.2% | 908 | $44,300,000 | $44,299,728 | 6 | Lionsgate | - |
| 11 | 12 | +1 | Lords of Dogtown | $1,800,000 | $1,851,630 | +$51,630 | +2.9% | 1,865 | $9,300,000 | $9,387,968 | 2 | Sony Pictures Releasing | - |
| 12 | 10 | -2 | High Tension | $1,800,000 | $1,897,705 | +$97,705 | +5.4% | 1,323 | $1,800,000 | $1,897,705 | 1 | Lionsgate | - |
