| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Madagascar | $28,700,000 | $28,110,235 | -$589,765 | -2.1% | 4,142 | $101,000,000 | $100,377,791 | 2 | DreamWorks Distribution | - |
| 2 | 2 | - | The Longest Yard | $26,100,000 | $26,078,156 | -$21,844 | <0.1% | 3,634 | $95,800,000 | $95,782,410 | 2 | Paramount Pictures | - |
| 3 | 3 | - | Star Wars: Episode III - Revenge of the Sith | $26,000,000 | $25,088,336 | -$911,664 | -3.5% | 3,650 | $308,800,000 | $307,892,961 | 3 | Twentieth Century Fox | - |
| 4 | 4 | - | Cinderella Man | $18,600,000 | $18,320,205 | -$279,795 | -1.5% | 2,812 | $18,600,000 | $18,320,205 | 1 | Universal Pictures | - |
| 5 | 5 | - | The Sisterhood of the Traveling Pants | $10,200,000 | $9,833,340 | -$366,660 | -3.6% | 2,583 | $14,000,000 | $13,575,149 | 1 | Warner Bros. | - |
| 6 | 6 | - | Lords of Dogtown | $5,700,000 | $5,623,373 | -$76,627 | -1.3% | 1,865 | $5,700,000 | $5,623,373 | 1 | Sony Pictures Releasing | - |
| 7 | 7 | - | Monster-in-Law | $5,300,000 | - | - | - | 3,025 | $70,400,000 | - | 4 | New Line Cinema | - |
| 8 | 8 | - | Crash | $3,300,000 | $3,266,884 | -$33,116 | -1% | 1,319 | $41,000,000 | $40,932,504 | 5 | Lionsgate | - |
| 9 | 9 | - | Kicking & Screaming | $2,100,000 | $2,311,155 | +$211,155 | +10.1% | 1,827 | $47,500,000 | $47,720,545 | 4 | Universal Pictures | - |
| 10 | 10 | - | Unleashed | $890,000 | - | - | - | 575 | $23,600,000 | - | 4 | Rogue Pictures | - |
| 11 | 11 | - | The Interpreter | $760,000 | $799,175 | +$39,175 | +5.2% | 686 | $70,400,000 | $70,405,780 | 7 | Universal Pictures | - |
| 12 | 12 | - | Kingdom of Heaven | $625,000 | $607,075 | -$17,925 | -2.9% | 571 | $46,100,000 | $46,117,399 | 5 | Twentieth Century Fox | - |
| 13 | 22 | +9 | Layer Cake | $345,603 | $142,000 | -$203,603 | -58.9% | 200 | $1,166,704 | $1,062,000 | 4 | Sony Pictures Classics | - |
| 14 | 23 | +9 | Ladies in Lavender | $315,047 | $139,000 | -$176,047 | -55.9% | 96 | $2,055,667 | $1,963,000 | 6 | IDP Distribution | - |
