| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Star Wars: Episode III - Revenge of the Sith | $2,047,398 | -50.6% | 497 | - | $4,119 | $18,167,104 | 3 | 20th Century Fox International | false | false |
| 2 | - | Unleashed | $872,531 | - | 249 | - | $3,504 | $872,531 | 1 | New World Pictures | true | false |
| 3 | - | Kung Fu Hustle | $545,439 | - | 201 | - | $2,713 | $545,439 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | Kingdom of Heaven | $542,388 | -40.4% | 410 | -24 | $1,322 | $13,019,088 | 5 | 20th Century Fox International | false | false |
| 5 | 3 | Un rey en La Habana | $363,166 | -39.8% | 267 | +2 | $1,360 | $1,134,233 | 2 | Sony Pictures Releasing | false | false |
| 6 | 5 | It's Not You, It's Me | $341,802 | -12% | 100 | +26 | $3,418 | $877,965 | 2 | Notro Films | false | false |
| 7 | 4 | Tapas | $335,662 | -26.1% | 201 | - | $1,669 | $2,928,915 | 4 | Filmax | false | false |
| 8 | 6 | The Interpreter | $198,158 | -29.9% | 154 | -33 | $1,286 | $7,232,262 | 8 | United International Pictures | false | false |
| 9 | 7 | The Eye 2 | $141,551 | -46.7% | 197 | - | $718 | $472,246 | 2 | DeAPlaneta | false | false |
| 10 | 8 | 11:14 | $137,463 | -37.4% | 80 | - | $1,718 | $419,379 | 2 | Filmax | false | false |
| 11 | 9 | Sahara | $125,405 | -35.2% | 146 | -25 | $858 | $4,354,701 | 7 | United International Pictures | false | false |
| 12 | 10 | After the Sunset | $106,846 | -43.1% | 140 | -46 | $763 | $4,383,602 | 7 | TriPictures | false | false |
| 13 | 11 | The Pacifier | $72,066 | -36.2% | 157 | -38 | $459 | $5,952,539 | 9 | Buena Vista International | false | false |
| 14 | - | Genesis | $49,941 | - | 31 | - | $1,611 | $49,941 | 1 | - | true | false |
| 15 | 13 | Things to Do Before You're 30 | $47,898 | -37.4% | 76 | -15 | $630 | $1,081,615 | 6 | DeAPlaneta | false | false |
| 16 | 14 | Ladies in Lavender | $46,178 | -23% | 36 | - | $1,282 | $580,166 | 5 | Filmax | false | false |
| 17 | - | Around the Bend | $40,733 | - | 34 | - | $1,198 | $40,733 | 1 | Warner Bros. | true | false |
| 18 | - | The Art of Losing | $36,665 | - | 40 | - | $916 | $36,665 | 1 | Alta Films | true | false |
| 19 | 15 | Arsène Lupin | $29,356 | -39.8% | 45 | -8 | $652 | $450,627 | 4 | Vértigo Films | false | false |
| 20 | - | Morir en San Hilario | $28,549 | - | 29 | - | $984 | $28,549 | 1 | Filmax | true | false |
