| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Star Wars: Episode III - Revenge of the Sith | $55,100,000 | $55,205,972 | +$105,972 | +0.2% | 3,663 | $255,500,000 | $255,648,711 | 2 | Twentieth Century Fox | - |
| 2 | 2 | - | The Longest Yard | $48,100,000 | $47,606,480 | -$493,520 | -1% | 3,634 | $48,100,000 | $47,606,480 | 1 | Paramount Pictures | - |
| 3 | 3 | - | Madagascar | $47,100,000 | $47,224,594 | +$124,594 | +0.3% | 4,131 | $47,100,000 | $47,224,594 | 1 | DreamWorks Distribution | - |
| 4 | 4 | - | Monster-in-Law | $9,300,000 | - | - | - | 3,230 | $58,900,000 | - | 3 | New Line Cinema | - |
| 5 | 5 | - | Kicking & Screaming | $4,800,000 | $5,131,195 | +$331,195 | +6.9% | 2,966 | $42,500,000 | $42,744,775 | 3 | Universal Pictures | - |
| 6 | 6 | - | Crash | $4,700,000 | $4,658,473 | -$41,527 | -0.9% | 1,680 | $34,800,000 | $34,796,250 | 4 | Lionsgate | - |
| 7 | 7 | - | The Interpreter | $2,200,000 | $2,072,670 | -$127,330 | -5.8% | 1,171 | $68,800,000 | $68,665,930 | 6 | Universal Pictures | - |
| 8 | 8 | - | Unleashed | $1,900,000 | - | - | - | 1,419 | $21,500,000 | - | 3 | Rogue Pictures | - |
| 9 | 9 | - | Kingdom of Heaven | $1,700,000 | $1,691,570 | -$8,430 | -0.5% | 1,328 | $44,500,000 | $44,515,801 | 4 | Twentieth Century Fox | - |
| 10 | 10 | - | House of Wax | $1,300,000 | $1,304,602 | +$4,602 | +0.4% | 1,635 | $29,500,000 | $29,537,604 | 4 | Warner Bros. | - |
| 11 | 11 | - | The Hitchhiker's Guide to the Galaxy | $642,000 | $722,748 | +$80,748 | +12.6% | 801 | $48,500,000 | $48,541,322 | 5 | Walt Disney Studios Motion Pictures | - |
| 12 | 13 | +1 | Ladies in Lavender | $422,221 | - | - | - | 88 | $1,466,089 | - | 5 | IDP Distribution | - |
| 13 | 17 | +4 | Layer Cake | $328,497 | - | - | - | 91 | $633,624 | - | 3 | Sony Pictures Classics | - |
| 14 | 18 | +4 | Enron: The Smartest Guys in the Room | $326,411 | - | - | - | 146 | $2,554,817 | - | 6 | Magnolia Pictures | - |
