| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Star Wars: Episode III - Revenge of the Sith | $108,500,000 | $108,435,841 | -$64,159 | <0.1% | 3,661 | $158,500,000 | $158,449,700 | 1 | Twentieth Century Fox | - |
| 2 | 2 | - | Monster-in-Law | $14,400,000 | - | - | - | 3,424 | $44,200,000 | - | 2 | New Line Cinema | - |
| 3 | 3 | - | Kicking & Screaming | $10,500,000 | $10,721,715 | +$221,715 | +2.1% | 3,470 | $34,000,000 | $34,196,720 | 2 | Universal Pictures | - |
| 4 | 4 | - | Crash | $5,500,000 | $5,546,006 | +$46,006 | +0.8% | 1,905 | $27,600,000 | $27,648,811 | 3 | Lionsgate | - |
| 5 | 5 | - | Unleashed | $3,800,000 | - | - | - | 1,962 | $17,600,000 | - | 2 | Rogue Pictures | - |
| 6 | 6 | - | Kingdom of Heaven | $3,400,000 | $3,537,201 | +$137,201 | +4% | 2,808 | $41,000,000 | $41,218,408 | 3 | Twentieth Century Fox | - |
| 7 | 7 | - | House of Wax | $3,400,000 | $3,288,419 | -$111,581 | -3.3% | 2,766 | $41,000,000 | $26,912,839 | 3 | Warner Bros. | - |
| 8 | 8 | - | The Interpreter | $2,800,000 | $2,910,580 | +$110,580 | +3.9% | 2,164 | $65,300,000 | $65,403,045 | 5 | Universal Pictures | - |
| 9 | 9 | - | The Hitchhiker's Guide to the Galaxy | $2,000,000 | $2,054,904 | +$54,904 | +2.7% | 2,211 | $46,900,000 | $46,902,653 | 4 | Walt Disney Studios Motion Pictures | - |
| 10 | 10 | - | Mindhunters | $909,000 | - | - | - | 1,040 | $3,500,000 | - | 2 | Dimension Films | - |
