| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Monster-in-Law | $24,000,000 | - | - | - | 3,424 | $24,000,000 | - | 1 | New Line Cinema | - |
| 2 | 2 | - | Kicking & Screaming | $20,900,000 | $20,159,925 | -$740,075 | -3.5% | 3,455 | $20,900,000 | $20,159,925 | 1 | Universal Pictures | - |
| 3 | 3 | - | Unleashed | $10,600,000 | - | - | - | 1,957 | $10,600,000 | - | 1 | Rogue Pictures | - |
| 4 | 4 | - | Kingdom of Heaven | $9,600,000 | $9,625,509 | +$25,509 | +0.3% | 3,219 | $35,100,000 | $35,097,419 | 2 | Twentieth Century Fox | - |
| 5 | 5 | - | Crash | $7,200,000 | $7,021,391 | -$178,609 | -2.5% | 1,876 | $19,800,000 | $19,614,256 | 2 | Lionsgate | - |
| 6 | 6 | - | House of Wax | $6,300,000 | $6,563,440 | +$263,440 | +4.2% | 3,111 | $21,700,000 | $21,946,754 | 2 | Warner Bros. | - |
| 7 | 7 | - | The Hitchhiker's Guide to the Galaxy | $4,800,000 | $5,049,938 | +$249,938 | +5.2% | 2,770 | $43,300,000 | $43,516,918 | 3 | Walt Disney Studios Motion Pictures | - |
| 8 | 8 | - | The Interpreter | $4,400,000 | $4,592,505 | +$192,505 | +4.4% | 2,602 | $61,000,000 | $61,161,945 | 4 | Universal Pictures | - |
| 9 | 9 | - | xXx: State of the Union | $2,200,000 | $2,134,772 | -$65,228 | -3% | 2,387 | $24,400,000 | $24,340,577 | 3 | Revolution Studios | - |
| 10 | 10 | - | Mindhunters | $2,000,000 | - | - | - | 1,040 | $2,000,000 | - | 1 | Dimension Films | - |
| 11 | 11 | - | Sahara | $1,900,000 | $1,806,454 | -$93,546 | -4.9% | 1,565 | $64,500,000 | $64,363,595 | 6 | Paramount Pictures | - |
| 12 | 12 | - | The Amityville Horror | $1,600,000 | $1,624,161 | +$24,161 | +1.5% | 1,434 | $63,100,000 | $63,084,329 | 5 | Metro-Goldwyn-Mayer (MGM) | - |
