| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Guess Who | $23,317,835 | - | 3,147 | - | $7,409 | $23,317,835 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Miss Congeniality 2: Armed & Fabulous | $15,975,292 | - | 3,233 | - | $4,941 | $19,030,596 | 1 | Warner Bros. | true | false |
| 3 | - | Robots | $15,541,127 | - | 3,431 | - | $4,529 | $89,928,656 | 3 | Twentieth Century Fox | false | false |
| 4 | - | The Ring Two | $15,170,182 | - | 3,341 | - | $4,540 | $59,455,475 | 2 | DreamWorks Distribution | false | false |
| 5 | - | The Pacifier | $9,698,105 | - | 3,102 | - | $3,126 | $87,443,982 | 4 | Walt Disney Studios Motion Pictures | false | false |
| 6 | - | Hitch | $4,885,290 | - | 2,233 | - | $2,187 | $167,046,474 | 7 | Sony Pictures Releasing | false | false |
| 7 | - | Ice Princess | $4,688,392 | - | 2,501 | - | $1,874 | $14,297,553 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 8 | - | Hostage | $4,667,000 | - | 1,977 | - | $2,360 | $26,730,000 | 3 | Miramax | false | true |
| 9 | - | Be Cool | $3,201,407 | - | 1,883 | - | $1,700 | $52,706,780 | 4 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 10 | - | Million Dollar Baby | $2,918,789 | - | 1,710 | - | $1,706 | $94,464,754 | 15 | Warner Bros. | false | false |
| 11 | - | Constantine | $1,403,472 | - | 1,005 | - | $1,396 | $72,846,709 | 6 | Warner Bros. | false | false |
| 12 | - | The Upside of Anger | $1,397,000 | - | 167 | - | $8,365 | $4,163,000 | 3 | New Line Cinema | false | true |
| 13 | - | Diary of a Mad Black Woman | $1,102,128 | - | 802 | - | $1,374 | $49,552,908 | 5 | Lionsgate Films | false | false |
| 14 | - | Melinda and Melinda | $802,023 | - | 95 | - | $8,442 | $1,051,218 | 2 | - | false | false |
| 15 | - | Sideways | $648,093 | - | 413 | - | $1,569 | $70,507,449 | 23 | - | false | false |
| 16 | - | Downfall | $554,036 | - | 128 | - | $4,328 | $2,207,036 | 6 | Newmarket Films | false | true |
| 17 | - | Millions | $542,550 | - | 77 | - | $7,046 | $971,771 | 3 | - | false | false |
| 18 | - | Bride & Prejudice | $484,333 | - | 261 | - | $1,855 | $5,577,333 | 7 | Miramax | false | true |
| 19 | - | The Aviator | $461,465 | - | 405 | - | $1,139 | $101,270,465 | 15 | Miramax | false | true |
| 20 | - | Because of Winn-Dixie | $414,507 | - | 604 | - | $686 | $31,029,164 | 6 | Twentieth Century Fox | false | false |
| 21 | - | Meet the Fockers | $407,585 | - | 350 | - | $1,164 | $277,700,045 | 14 | Universal Pictures | false | false |
| 22 | - | Man of the House | $338,237 | - | 487 | - | $694 | $18,871,198 | 5 | Sony Pictures Releasing | false | false |
| 23 | - | Hotel Rwanda | $293,095 | - | 254 | - | $1,153 | $22,985,387 | 14 | United Artists | false | false |
| 24 | - | Racing Stripes | $226,688 | - | 353 | - | $642 | $48,489,700 | 11 | Warner Bros. | false | false |
| 25 | - | Coach Carter | $169,651 | - | 214 | - | $792 | $66,804,677 | 11 | Paramount Pictures | false | false |
| 26 | - | Are We There Yet? | $134,062 | - | 186 | - | $720 | $80,345,816 | 10 | Revolution Studios | false | false |
| 27 | - | The Phantom of the Opera | $117,437 | - | 135 | - | $869 | $50,545,589 | 14 | Warner Bros. | false | false |
| 28 | - | Hide and Seek | $106,993 | - | 159 | - | $672 | $50,770,897 | 9 | Twentieth Century Fox | false | false |
| 29 | - | The Wedding Date | $101,185 | - | 176 | - | $574 | $31,597,605 | 8 | Universal Pictures | false | false |
| 30 | - | Steamboy | $98,653 | - | 46 | - | $2,144 | $297,857 | 2 | Triumph Releasing Corporation | false | false |
| 31 | - | Kinsey | $83,859 | - | 36 | - | $2,329 | $10,226,803 | 20 | - | false | false |
| 32 | - | The Jacket | $83,324 | - | 85 | - | $980 | $6,177,285 | 4 | Warner Independent Pictures (WIP) | false | false |
| 33 | - | Schultze Gets the Blues | $79,211 | - | 34 | - | $2,329 | $286,475 | 6 | Paramount Classics | false | false |
| 34 | - | A Series of Unfortunate Events | $72,335 | - | 109 | - | $663 | $118,474,037 | 15 | Paramount Pictures | false | false |
| 35 | - | Inside Deep Throat | $25,715 | - | 21 | - | $1,224 | $616,624 | 7 | Universal Pictures | false | false |
| 36 | - | Fat Albert | $13,597 | - | 40 | - | $339 | $48,106,225 | 14 | Twentieth Century Fox | false | false |
| 37 | - | Elektra | $5,370 | - | 12 | - | $447 | $24,408,533 | 11 | Twentieth Century Fox | false | false |
