| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | A Quiet Place Part II | - | - | - | $57,088,948 | 3,744 | $160,072,261 | 35.7% | May 28, 2021 | Paramount Pictures |
| 2 | Cruella | - | - | - | $26,532,683 | 3,922 | $86,103,234 | 30.8% | May 28, 2021 | Walt Disney Studios Motion Pictures |
| 3 | Wrath of Man | - | - | - | $22,737,520 | 3,007 | $27,466,489 | 82.8% | May 7, 2021 | United Artists Releasing |
| 4 | Spiral | - | - | - | $20,205,126 | 2,991 | $23,216,862 | 87% | May 14, 2021 | Lionsgate Films |
| 5 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | - | - | - | $10,254,300 | 2,087 | $49,505,008 | 20.7% | Apr 23, 2021 | FUNimation Entertainment |
| 6 | Raya and the Last Dragon | - | - | - | $9,755,316 | 2,375 | $54,723,032 | 17.8% | Mar 5, 2021 | Walt Disney Studios Motion Pictures |
| 7 | Godzilla vs. Kong | - | - | - | $6,625,254 | 3,084 | $100,916,094 | 6.6% | Mar 31, 2021 | Warner Bros. |
| 8 | Those Who Wish Me Dead | - | - | - | $6,154,173 | 3,379 | $7,407,200 | 83.1% | May 14, 2021 | Warner Bros. |
| 9 | Mortal Kombat | - | - | - | $6,021,607 | 3,114 | $42,326,031 | 14.2% | Apr 23, 2021 | Warner Bros. |
| 10 | Here Today | - | - | - | $2,696,311 | 1,230 | $2,807,494 | 96% | May 7, 2021 | Stage 6 Films |
| 11 | Finding You | - | - | - | $2,496,337 | 1,447 | $2,753,985 | 90.6% | May 14, 2021 | Roadside Attractions |
| 12 | Nobody | - | - | - | $2,197,200 | 2,567 | $27,568,035 | 8% | Mar 26, 2021 | Universal Pictures |
| 13 | Separation | - | - | - | $2,197,197 | 1,911 | $4,509,143 | 48.7% | Apr 30, 2021 | Open Road Films (II) |
| 14 | The Unholy | - | - | - | $1,995,924 | 2,057 | $15,532,137 | 12.9% | Apr 2, 2021 | Screen Gems |
| 15 | Dream Horse | - | - | - | $1,918,625 | 1,284 | $2,913,328 | 65.9% | May 21, 2021 | Bleecker Street Media |
| 16 | Profile | - | - | - | $1,735,090 | 2,104 | $1,744,740 | 99.4% | May 14, 2021 | Focus Features |
| 17 | Tom & Jerry | - | - | - | $1,425,982 | 2,563 | $46,536,687 | 3.1% | Feb 26, 2021 | Warner Bros. |
| 18 | Scoob! | - | - | - | $850,000 | - | $2,188,425 | 38.8% | May 21, 2021 | Warner Bros. |
| 19 | The Croods: A New Age | - | - | - | $679,225 | 2,211 | $58,568,815 | 1.2% | Nov 25, 2020 | Universal Pictures |
| 20 | Long Weekend | - | - | - | $487,839 | 821 | $1,018,532 | 47.9% | Mar 12, 2021 | Stage 6 Films |
| 21 | World War Z 2021 Re-release | - | - | - | $448,000 | 80 | $448,000 | 100% | May 28, 2021 | Paramount Pictures |
| 22 | Four Good Days | - | - | - | $436,332 | 489 | $837,849 | 52.1% | Apr 30, 2021 | Vertical Entertainment |
| 23 | Top Gun 2021 Re-release | - | - | - | $408,937 | 153 | $457,577 | 89.4% | May 14, 2021 | Paramount Pictures |
| 24 | The Girl Who Believes in Miracles | - | - | - | $327,390 | 1,012 | $3,163,362 | 10.3% | Apr 2, 2021 | Atlas Distribution Company |
| 25 | The Water Man | - | - | - | $294,748 | 311 | $383,234 | 76.9% | May 7, 2021 | RLJE Films |
| 26 | The Courier | - | - | - | $284,915 | 1,641 | $6,613,432 | 4.3% | Mar 19, 2021 | Roadside Attractions |
| 27 | Final Account | - | - | - | $283,995 | 308 | $308,976 | 91.9% | May 21, 2021 | Focus Features |
| 28 | Together Together | - | - | - | $283,316 | 665 | $1,437,938 | 19.7% | Apr 23, 2021 | Bleecker Street Media |
| 29 | New Order | - | - | - | $274,616 | 236 | $303,556 | 90.5% | May 21, 2021 | Neon |
| 30 | The Dry | - | - | - | $241,460 | 186 | $364,237 | 66.3% | May 21, 2021 | IFC Films |
| 31 | Scott Pilgrim vs. the World 10th Anniversary (2021 Re-release) | - | - | - | $217,585 | 448 | $1,867,625 | 11.7% | - | Universal Pictures |
| 32 | Minari | - | - | - | $205,764 | 912 | $3,110,580 | 6.6% | Feb 12, 2021 | A24 |
| 33 | The Truffle Hunters | - | - | - | $147,784 | 105 | $521,202 | 28.4% | Mar 5, 2021 | Sony Pictures Classics |
| 34 | The Father | - | - | - | $147,421 | 933 | $2,122,771 | 6.9% | Feb 26, 2021 | Sony Pictures Classics |
| 35 | The Djinn | - | - | - | $122,052 | 44 | $124,772 | 97.8% | May 14, 2021 | IFC Films |
| 36 | Walking with Herb | - | - | - | $120,226 | 507 | $120,226 | 100% | May 7, 2021 | Fathom Events |
| 37 | Limbo | - | - | - | $103,080 | 213 | $224,405 | 45.9% | Apr 30, 2021 | Focus Features |
| 38 | The Paper Tigers | - | - | - | $90,833 | 65 | $112,691 | 80.6% | May 7, 2021 | Well Go USA Entertainment |
| 39 | My Love | - | - | - | $85,187 | 25 | $86,252 | 98.8% | May 7, 2021 | CMC Pictures |
| 40 | Mission Stories | - | - | - | $83,437 | 44 | $87,059 | 95.8% | May 7, 2021 | Excel Entertainment |
| 41 | The Resort | - | - | - | $80,425 | 114 | $191,996 | 41.9% | Apr 30, 2021 | Vertical Entertainment |
| 42 | The War with Grandpa | - | - | - | $75,815 | 2,365 | $21,277,892 | 0.4% | Oct 9, 2020 | 101 Studios |
| 43 | Cliff Walkers | - | - | - | $71,575 | 65 | $152,972 | 46.8% | Apr 30, 2021 | CMC Pictures |
| 44 | The Killing of Two Lovers | - | - | - | $66,068 | 36 | $71,162 | 92.8% | May 14, 2021 | Neon |
| 45 | Riders of Justice | - | - | - | $47,460 | 18 | $77,115 | 61.5% | May 14, 2021 | Magnolia Pictures |
| 46 | French Exit | - | - | - | $43,995 | 493 | $741,895 | 5.9% | Feb 12, 2021 | Sony Pictures Classics |
| 47 | Chaos Walking | - | - | - | $39,752 | 2,132 | $13,287,908 | 0.3% | Mar 5, 2021 | Lionsgate Films |
| 48 | The Swimming Pool 2021 Re-release | - | - | - | $37,678 | 10 | $211,467 | 17.8% | May 14, 2021 | Rialto Distribution |
| 49 | Voyagers | - | - | - | $36,395 | 1,996 | $3,149,935 | 1.2% | Apr 9, 2021 | Lionsgate Films |
| 50 | The Human Factor | - | - | - | $35,570 | 90 | $36,693 | 96.9% | May 7, 2021 | Sony Pictures Classics |
| 51 | Wonder Woman 1984 | - | - | - | $35,342 | 2,218 | $46,801,036 | <0.1% | Dec 25, 2020 | Warner Bros. |
| 52 | Wrong Turn | - | - | - | $35,296 | 259 | $1,251,184 | 2.8% | Jan 26, 2021 | Saban Films |
| 53 | Mainstream | - | - | - | $34,673 | 76 | $35,696 | 97.1% | May 7, 2021 | IFC Films |
| 54 | Gunda | - | - | - | $27,552 | 35 | $115,691 | 23.8% | Apr 16, 2021 | Neon |
| 55 | Shiva Baby | - | - | - | $24,727 | 27 | $159,294 | 15.5% | Apr 2, 2021 | Utopia |
| 56 | About Endlessness | - | - | - | $19,632 | 17 | $51,386 | 38.2% | Apr 30, 2021 | Magnolia Pictures |
| 57 | Monster Hunter | - | - | - | $16,164 | 1,817 | $15,162,470 | 0.1% | Dec 18, 2020 | Screen Gems |
| 58 | Equal Standard | - | - | - | $15,938 | 25 | $15,938 | 100% | May 7, 2021 | Mutiny Pictures |
| 59 | The Perfect Candidate | - | - | - | $13,702 | 17 | $30,134 | 45.5% | May 14, 2021 | Music Box Films |
| 60 | In the Earth | - | - | - | $12,969 | 571 | $1,113,723 | 1.2% | Apr 16, 2021 | Neon |
| 61 | State Funeral | - | - | - | $9,913 | 2 | $11,342 | 87.4% | May 7, 2021 | MUBI |
| 62 | 100% Wolf | - | - | - | $9,837 | 124 | $658,764 | 1.5% | Oct 9, 2020 | Viva Pictures |
| 63 | There Is No Evil | - | - | - | $7,936 | 7 | $8,063 | 98.4% | May 14, 2021 | Kino Lorber |
| 64 | Ghost Master | - | - | - | $5,943 | 2 | $6,136 | 96.9% | May 14, 2021 | Indican Pictures |
| 65 | 2021 Oscar Nominated Short Films: Live Action | - | - | - | $3,881 | 184 | $443,050 | 0.9% | Apr 2, 2021 | Magnolia Pictures |
| 66 | Endless Rain | - | - | - | $3,289 | 14 | $7,334 | 44.8% | Apr 30, 2021 | Sony Pictures Releasing |
| 67 | Paper Spiders | - | - | - | $2,992 | 17 | $2,992 | 100% | May 7, 2021 | Entertainment Squad |
| 68 | Six Minutes to Midnight | - | - | - | $2,928 | 145 | $132,500 | 2.2% | Mar 26, 2021 | IFC Films |
| 69 | Psycho Goreman | - | - | - | $2,402 | 70 | $95,182 | 2.5% | Jan 22, 2021 | RLJE Films |
| 70 | Held | - | - | - | $1,562 | 129 | $142,817 | 1.1% | Apr 9, 2021 | Magnolia Pictures |
| 71 | The Unthinkable | - | - | - | $974 | 3 | $974 | 100% | May 7, 2021 | Magnolia Pictures |
| 72 | The Incredible 25th Year of Mitzi Bearclaw | - | - | - | $344 | 2 | $10,368 | 3.3% | Feb 12, 2021 | Indican Pictures |
| 73 | Lamb of God: The Concert Film | - | - | - | $289 | 138 | $744,813 | <0.1% | Mar 12, 2021 | Excel Entertainment |
| 74 | Funhouse | - | - | - | $288 | 3 | $507 | 56.8% | May 28, 2021 | Magnet Releasing |
| 75 | The World to Come | - | - | - | $161 | 277 | $116,143 | 0.1% | Feb 12, 2021 | Bleecker Street Media |
