| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Gladiator | - | - | - | $49,016,336 | 3,188 | $187,705,427 | 26.1% | May 5, 2000 | DreamWorks Distribution |
| 2 | U-571 | - | - | - | $10,263,805 | 2,820 | $77,122,415 | 13.3% | Apr 21, 2000 | Universal Pictures |
| 3 | Frequency | - | - | - | $8,254,107 | 2,631 | $45,010,278 | 18.3% | Apr 28, 2000 | New Line Cinema |
| 4 | The Flintstones in Viva Rock Vegas | - | - | - | $7,764,940 | 3,125 | $35,268,275 | 22% | Apr 28, 2000 | Universal Pictures |
| 5 | Where the Heart Is | - | - | - | $6,882,682 | 2,439 | $33,772,838 | 20.4% | Apr 28, 2000 | Twentieth Century Fox |
| 6 | Love & Basketball | - | - | - | $3,851,571 | 1,245 | $27,459,615 | 14% | Apr 21, 2000 | New Line Cinema |
| 7 | Keeping the Faith | - | - | - | $3,682,039 | 2,171 | $37,047,880 | 9.9% | Apr 14, 2000 | Walt Disney Studios Motion Pictures |
| 8 | I Dreamed of Africa | - | - | - | $3,415,172 | 2,112 | $6,651,522 | 51.3% | May 5, 2000 | Sony Pictures Releasing |
| 9 | Rules of Engagement | - | - | - | $3,289,024 | 3,220 | $61,335,230 | 5.4% | Apr 7, 2000 | Paramount Pictures |
| 10 | 28 Days | - | - | - | $3,204,564 | 2,523 | $37,170,488 | 8.6% | Apr 14, 2000 | Sony Pictures Releasing |
| 11 | Erin Brockovich | - | - | - | $2,932,460 | 3,070 | $125,595,205 | 2.3% | Mar 17, 2000 | Universal Pictures |
| 12 | Final Destination | - | - | - | $2,120,131 | 2,587 | $53,331,147 | 4% | Mar 17, 2000 | New Line Cinema |
| 13 | Return to Me | - | - | - | $2,080,493 | 2,320 | $32,722,798 | 6.4% | Apr 7, 2000 | Metro-Goldwyn-Mayer (MGM) |
| 14 | The Road to El Dorado | - | - | - | $1,193,562 | 3,223 | $50,863,742 | 2.3% | Mar 31, 2000 | DreamWorks Distribution |
| 15 | High Fidelity | - | - | - | $1,053,242 | 1,231 | $27,287,137 | 3.9% | Mar 31, 2000 | Walt Disney Studios Motion Pictures |
| 16 | The Skulls | - | - | - | $908,105 | 2,416 | $35,046,120 | 2.6% | Mar 31, 2000 | Universal Pictures |
| 17 | Michael Jordan to the Max | - | - | - | $859,718 | 56 | $18,650,521 | 4.6% | May 5, 2000 | IMAX |
| 18 | American Beauty | - | - | - | $639,046 | 1,990 | $130,096,601 | 0.5% | Sep 15, 1999 | DreamWorks Distribution |
| 19 | American Psycho | - | - | - | $636,281 | 1,242 | $15,070,285 | 4.2% | Apr 14, 2000 | Lionsgate |
| 20 | Romeo Must Die | - | - | - | $597,764 | 2,641 | $55,973,336 | 1.1% | Mar 22, 2000 | Warner Bros. |
| 21 | The Virgin Suicides | - | - | - | $522,384 | 275 | $4,906,229 | 10.6% | Apr 21, 2000 | Paramount Classics |
| 22 | Up at the Villa | - | - | - | $482,014 | 112 | $2,933,161 | 16.4% | May 5, 2000 | USA Films |
| 23 | Gossip | - | - | - | $332,482 | 1,525 | $5,108,820 | 6.5% | Apr 21, 2000 | Warner Bros. |
| 24 | East Is East | - | - | - | $302,317 | 157 | $4,177,818 | 7.2% | Apr 14, 2000 | Miramax |
| 25 | Mysteries of Egypt | - | - | - | $281,268 | 27 | $40,593,486 | 0.7% | Aug 21, 1998 | IMAX |
| 26 | T-Rex: Back to the Cretaceous | - | - | - | $264,664 | 38 | $53,354,743 | 0.5% | Oct 23, 1998 | IMAX |
| 27 | Toy Story 2 | - | - | - | $222,649 | 3,257 | $245,852,179 | <0.1% | Nov 19, 1999 | Walt Disney Studios Motion Pictures |
| 28 | Galapagos | - | - | - | $221,959 | 14 | $18,630,372 | 1.2% | Oct 29, 1999 | IMAX |
| 29 | East/West | - | - | - | $216,811 | 70 | $2,321,029 | 9.3% | Apr 7, 2000 | Sony Pictures Classics |
| 30 | Pitch Black | - | - | - | $215,239 | 1,930 | $39,240,659 | 0.5% | Feb 18, 2000 | USA Films |
| 31 | Scream 3 | - | - | - | $214,021 | 3,467 | $89,143,175 | 0.2% | Feb 4, 2000 | Dimension Films |
| 32 | Luminarias | - | - | - | $147,274 | 51 | $292,309 | 50.4% | May 5, 2000 | New Latin Pictures |
| 33 | Chal Mere Bhai | - | - | - | $141,939 | 25 | $199,227 | 71.2% | May 5, 2000 | Eros Worldwide |
| 34 | The Whole Nine Yards | - | - | - | $130,469 | 2,910 | $57,262,492 | 0.2% | Feb 18, 2000 | Warner Bros. |
| 35 | Ready to Rumble | - | - | - | $122,517 | 2,585 | $12,394,327 | 1% | Apr 7, 2000 | Warner Bros. |
| 36 | Next Friday | - | - | - | $119,809 | 1,420 | $57,328,603 | 0.2% | Jan 12, 2000 | New Line Cinema |
| 37 | The Cider House Rules | - | - | - | $119,285 | 1,738 | $57,545,092 | 0.2% | Dec 10, 1999 | Miramax |
| 38 | Siegfried & Roy: The Magic Box | - | - | - | $109,811 | 22 | $5,231,283 | 2.1% | Oct 1, 1999 | IMAX |
| 39 | Ghost Dog: The Way of the Samurai | - | - | - | $106,910 | 109 | $3,308,029 | 3.2% | Mar 3, 2000 | Artisan Entertainment |
| 40 | Where the Money Is | - | - | - | $104,901 | 1,538 | $5,661,798 | 1.9% | Apr 14, 2000 | USA Films |
| 41 | My Dog Skip | - | - | - | $104,479 | 2,331 | $34,134,641 | 0.3% | Jan 14, 2000 | Warner Bros. |
| 42 | The Other Conquest | - | - | - | $99,005 | 74 | $886,410 | 11.2% | Apr 21, 2000 | Hombre d'Oro |
| 43 | Alien Adventure | - | - | - | $95,159 | 10 | $8,959,784 | 1.1% | Aug 20, 1999 | nWave Pictures |
| 44 | The Last September | - | - | - | $95,048 | 56 | $478,053 | 19.9% | Apr 21, 2000 | Trimark Pictures |
| 45 | Timecode | - | - | - | $91,141 | 130 | $1,057,750 | 8.6% | Apr 28, 2000 | Sony Pictures Releasing |
| 46 | The Color of Paradise | - | - | - | $85,980 | 33 | $1,817,216 | 4.7% | Mar 31, 2000 | Sony Pictures Classics |
| 47 | Galaxy Quest | - | - | - | $85,718 | 2,450 | $71,583,916 | 0.1% | Dec 25, 1999 | DreamWorks Distribution |
| 48 | Bicentennial Man | - | - | - | $80,782 | 2,767 | $58,223,861 | 0.1% | Dec 17, 1999 | Walt Disney Studios Motion Pictures |
| 49 | Cirque du Soleil: Journey of Man | - | - | - | $79,009 | 22 | $15,627,434 | 0.5% | May 5, 2000 | Sony Pictures Classics |
| 50 | The Big Kahuna | - | - | - | $75,767 | 309 | $3,165,544 | 2.4% | Apr 28, 2000 | Lionsgate |
| 51 | God's Army | - | - | - | $69,441 | 50 | $2,637,726 | 2.6% | Mar 10, 2000 | Zion Films |
| 52 | Mission to Mars | - | - | - | $66,163 | 3,101 | $60,883,407 | 0.1% | Mar 10, 2000 | Walt Disney Studios Motion Pictures |
| 53 | The Basket | - | - | - | $61,300 | 113 | $367,098 | 16.7% | Aug 20, 1999 | North by Northwest Entertainment |
| 54 | Croupier | - | - | - | $55,565 | 141 | $6,201,143 | 0.9% | Apr 21, 2000 | - |
| 55 | Me Myself I | - | - | - | $52,714 | 59 | $369,975 | 14.2% | Apr 7, 2000 | Sony Pictures Classics |
| 56 | All About My Mother | - | - | - | $50,934 | 145 | $8,272,296 | 0.6% | Nov 5, 1999 | Sony Pictures Classics |
| 57 | Island of the Sharks | - | - | - | $40,613 | 17 | $10,658,505 | 0.4% | Apr 23, 1999 | IMAX |
| 58 | The Filth and the Fury | - | - | - | $38,222 | 29 | $612,192 | 6.2% | Mar 29, 2000 | Fine Line Features |
| 59 | The Tigger Movie | - | - | - | $35,986 | 2,818 | $45,554,533 | <0.1% | Feb 11, 2000 | Walt Disney Studios Motion Pictures |
