| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Gladiator | - | - | - | $45,843,807 | 3,188 | $187,705,427 | 24.4% | May 5, 2000 | DreamWorks Distribution |
| 2 | U-571 | - | - | - | $9,642,575 | 2,820 | $77,122,415 | 12.5% | Apr 21, 2000 | Universal Pictures |
| 3 | The Flintstones in Viva Rock Vegas | - | - | - | $7,505,605 | 3,125 | $35,268,275 | 21.3% | Apr 28, 2000 | Universal Pictures |
| 4 | Frequency | - | - | - | $7,074,948 | 2,631 | $45,010,278 | 15.7% | Apr 28, 2000 | New Line Cinema |
| 5 | Where the Heart Is | - | - | - | $5,899,440 | 2,439 | $33,772,838 | 17.5% | Apr 28, 2000 | Twentieth Century Fox |
| 6 | Love & Basketball | - | - | - | $3,694,497 | 1,245 | $27,459,615 | 13.5% | Apr 21, 2000 | New Line Cinema |
| 7 | Keeping the Faith | - | - | - | $3,462,279 | 2,171 | $37,047,880 | 9.3% | Apr 14, 2000 | Walt Disney Studios Motion Pictures |
| 8 | 28 Days | - | - | - | $3,003,733 | 2,523 | $37,170,488 | 8.1% | Apr 14, 2000 | Sony Pictures Releasing |
| 9 | I Dreamed of Africa | - | - | - | $2,927,286 | 2,112 | $6,651,522 | 44% | May 5, 2000 | Sony Pictures Releasing |
| 10 | Erin Brockovich | - | - | - | $2,747,975 | 3,070 | $125,595,205 | 2.2% | Mar 17, 2000 | Universal Pictures |
| 11 | Final Destination | - | - | - | $1,817,250 | 2,587 | $53,331,147 | 3.4% | Mar 17, 2000 | New Line Cinema |
| 12 | Rules of Engagement | - | - | - | $1,274,981 | 3,220 | $61,335,230 | 2.1% | Apr 7, 2000 | Paramount Pictures |
| 13 | The Road to El Dorado | - | - | - | $1,118,739 | 3,223 | $50,863,742 | 2.2% | Mar 31, 2000 | DreamWorks Distribution |
| 14 | The Skulls | - | - | - | $851,620 | 2,416 | $35,046,120 | 2.4% | Mar 31, 2000 | Universal Pictures |
| 15 | Return to Me | - | - | - | $792,330 | 2,320 | $32,722,798 | 2.4% | Apr 7, 2000 | Metro-Goldwyn-Mayer (MGM) |
| 16 | Michael Jordan to the Max | - | - | - | $736,896 | 56 | $18,650,521 | 4% | May 5, 2000 | IMAX |
| 17 | American Psycho | - | - | - | $545,382 | 1,242 | $15,070,285 | 3.6% | Apr 14, 2000 | Lionsgate |
| 18 | The Virgin Suicides | - | - | - | $447,756 | 275 | $4,906,229 | 9.1% | Apr 21, 2000 | Paramount Classics |
| 19 | High Fidelity | - | - | - | $431,013 | 1,231 | $27,287,137 | 1.6% | Mar 31, 2000 | Walt Disney Studios Motion Pictures |
| 20 | Up at the Villa | - | - | - | $413,154 | 112 | $2,933,161 | 14.1% | May 5, 2000 | USA Films |
| 21 | Gossip | - | - | - | $284,982 | 1,525 | $5,108,820 | 5.6% | Apr 21, 2000 | Warner Bros. |
| 22 | American Beauty | - | - | - | $278,773 | 1,990 | $130,096,601 | 0.2% | Sep 15, 1999 | DreamWorks Distribution |
| 23 | East Is East | - | - | - | $259,128 | 157 | $4,177,818 | 6.2% | Apr 14, 2000 | Miramax |
| 24 | Romeo Must Die | - | - | - | $241,390 | 2,641 | $55,973,336 | 0.4% | Mar 22, 2000 | Warner Bros. |
| 25 | Mysteries of Egypt | - | - | - | $241,086 | 27 | $40,593,486 | 0.6% | Aug 21, 1998 | IMAX |
| 26 | T-Rex: Back to the Cretaceous | - | - | - | $226,854 | 38 | $53,354,743 | 0.4% | Oct 23, 1998 | IMAX |
| 27 | Toy Story 2 | - | - | - | $190,842 | 3,257 | $245,852,179 | <0.1% | Nov 19, 1999 | Walt Disney Studios Motion Pictures |
| 28 | Galapagos | - | - | - | $190,248 | 14 | $18,630,372 | 1% | Oct 29, 1999 | IMAX |
| 29 | East/West | - | - | - | $185,838 | 70 | $2,321,029 | 8% | Apr 7, 2000 | Sony Pictures Classics |
| 30 | Pitch Black | - | - | - | $184,488 | 1,930 | $39,240,659 | 0.5% | Feb 18, 2000 | USA Films |
| 31 | Scream 3 | - | - | - | $183,444 | 3,467 | $89,143,175 | 0.2% | Feb 4, 2000 | Dimension Films |
| 32 | The Ninth Gate | - | - | - | $129,925 | 1,694 | $18,661,336 | 0.7% | Mar 10, 2000 | Artisan Entertainment |
| 33 | Luminarias | - | - | - | $126,234 | 51 | $292,309 | 43.2% | May 5, 2000 | New Latin Pictures |
| 34 | Chal Mere Bhai | - | - | - | $121,662 | 25 | $199,227 | 61.1% | May 5, 2000 | Eros Worldwide |
| 35 | The Whole Nine Yards | - | - | - | $111,828 | 2,910 | $57,262,492 | 0.2% | Feb 18, 2000 | Warner Bros. |
| 36 | Ready to Rumble | - | - | - | $105,012 | 2,585 | $12,394,327 | 0.8% | Apr 7, 2000 | Warner Bros. |
| 37 | Next Friday | - | - | - | $102,690 | 1,420 | $57,328,603 | 0.2% | Jan 12, 2000 | New Line Cinema |
| 38 | The Cider House Rules | - | - | - | $102,240 | 1,738 | $57,545,092 | 0.2% | Dec 10, 1999 | Miramax |
| 39 | The Last September | - | - | - | $95,048 | 56 | $478,053 | 19.9% | Apr 21, 2000 | Trimark Pictures |
| 40 | Siegfried & Roy: The Magic Box | - | - | - | $94,122 | 22 | $5,231,283 | 1.8% | Oct 1, 1999 | IMAX |
| 41 | Ghost Dog: The Way of the Samurai | - | - | - | $91,632 | 109 | $3,308,029 | 2.8% | Mar 3, 2000 | Artisan Entertainment |
| 42 | Where the Money Is | - | - | - | $89,910 | 1,538 | $5,661,798 | 1.6% | Apr 14, 2000 | USA Films |
| 43 | My Dog Skip | - | - | - | $89,550 | 2,331 | $34,134,641 | 0.3% | Jan 14, 2000 | Warner Bros. |
| 44 | The Other Conquest | - | - | - | $84,858 | 74 | $886,410 | 9.6% | Apr 21, 2000 | Hombre d'Oro |
| 45 | Alien Adventure | - | - | - | $81,564 | 10 | $8,959,784 | 0.9% | Aug 20, 1999 | nWave Pictures |
| 46 | Galaxy Quest | - | - | - | $80,332 | 2,450 | $71,583,916 | 0.1% | Dec 25, 1999 | DreamWorks Distribution |
| 47 | Timecode | - | - | - | $78,120 | 130 | $1,057,750 | 7.4% | Apr 28, 2000 | Sony Pictures Releasing |
| 48 | The Color of Paradise | - | - | - | $73,692 | 33 | $1,817,216 | 4.1% | Mar 31, 2000 | Sony Pictures Classics |
| 49 | Bicentennial Man | - | - | - | $69,240 | 2,767 | $58,223,861 | 0.1% | Dec 17, 1999 | Walt Disney Studios Motion Pictures |
| 50 | Cirque du Soleil: Journey of Man | - | - | - | $67,722 | 22 | $15,627,434 | 0.4% | May 5, 2000 | Sony Pictures Classics |
| 51 | Mission to Mars | - | - | - | $66,163 | 3,101 | $60,883,407 | 0.1% | Mar 10, 2000 | Walt Disney Studios Motion Pictures |
| 52 | The Big Kahuna | - | - | - | $64,938 | 309 | $3,165,544 | 2.1% | Apr 28, 2000 | Lionsgate |
| 53 | The Basket | - | - | - | $61,300 | 113 | $367,098 | 16.7% | Aug 20, 1999 | North by Northwest Entertainment |
| 54 | God's Army | - | - | - | $59,520 | 50 | $2,637,726 | 2.3% | Mar 10, 2000 | Zion Films |
| 55 | The Green Mile | - | - | - | $58,651 | 2,875 | $136,801,374 | <0.1% | Dec 10, 1999 | Warner Bros. |
| 56 | All About My Mother | - | - | - | $50,934 | 145 | $8,272,296 | 0.6% | Nov 5, 1999 | Sony Pictures Classics |
| 57 | Croupier | - | - | - | $47,622 | 141 | $6,201,143 | 0.8% | Apr 21, 2000 | - |
| 58 | Me Myself I | - | - | - | $45,180 | 59 | $369,975 | 12.2% | Apr 7, 2000 | Sony Pictures Classics |
| 59 | Island of the Sharks | - | - | - | $40,613 | 17 | $10,658,505 | 0.4% | Apr 23, 1999 | IMAX |
| 60 | The Filth and the Fury | - | - | - | $38,222 | 29 | $612,192 | 6.2% | Mar 29, 2000 | Fine Line Features |
| 61 | The Tigger Movie | - | - | - | $30,840 | 2,818 | $45,554,533 | <0.1% | Feb 11, 2000 | Walt Disney Studios Motion Pictures |
| 62 | The Sixth Sense | - | - | - | $29,380 | 2,821 | $293,506,292 | <0.1% | Aug 6, 1999 | Walt Disney Studios Motion Pictures |
| 63 | Committed | - | - | - | $8,517 | 13 | $40,361 | 21.1% | Apr 28, 2000 | Miramax |
