| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | What About Bob? | - | - | - | $35,653,451 | 1,805 | $63,707,829 | 56% | May 17, 1991 | Walt Disney Studios Motion Pictures |
| 2 | Backdraft | - | - | - | $33,423,475 | 1,983 | $77,868,585 | 42.9% | May 24, 1991 | Universal Pictures |
| 3 | F/X2 | - | - | - | $21,082,165 | 1,502 | $21,082,165 | 100% | May 10, 1991 | Orion Pictures |
| 4 | Oscar | - | - | - | $16,986,285 | 1,391 | $23,562,716 | 72.1% | Apr 26, 1991 | Walt Disney Studios Motion Pictures |
| 5 | Switch | - | - | - | $15,545,943 | 1,013 | $15,545,943 | 100% | May 10, 1991 | Warner Bros. |
| 6 | Madonna: Truth or Dare | - | - | - | $15,012,935 | 652 | $15,012,935 | 100% | May 10, 1991 | Miramax |
| 7 | Thelma & Louise | - | - | - | $14,641,331 | 1,180 | $45,360,915 | 32.3% | May 24, 1991 | Metro-Goldwyn-Mayer (MGM) |
| 8 | Hudson Hawk | - | - | - | $13,227,298 | 2,072 | $17,218,080 | 76.8% | May 24, 1991 | TriStar Pictures |
| 9 | Only the Lonely | - | - | - | $12,786,101 | 1,553 | $21,830,957 | 58.6% | May 24, 1991 | Twentieth Century Fox |
| 10 | The Silence of the Lambs | - | - | - | $12,260,507 | 1,642 | $130,742,922 | 9.4% | Feb 14, 1991 | Orion Pictures |
| 11 | One Good Cop | - | - | - | $11,276,846 | 1,454 | $11,276,846 | 100% | May 3, 1991 | Walt Disney Studios Motion Pictures |
| 12 | Out for Justice | - | - | - | $10,806,920 | 2,010 | $39,673,161 | 27.2% | Apr 12, 1991 | Warner Bros. |
| 13 | Soapdish | - | - | - | $10,602,621 | 1,275 | $36,489,888 | 29.1% | May 31, 1991 | Paramount Pictures |
| 14 | A Rage in Harlem | - | - | - | $10,438,504 | 545 | $10,438,504 | 100% | May 3, 1991 | Miramax |
| 15 | Toy Soldiers | - | - | - | $9,717,142 | 1,358 | $15,073,942 | 64.5% | Apr 26, 1991 | TriStar Pictures |
| 16 | A Kiss Before Dying | - | - | - | $9,681,692 | 1,546 | $15,429,177 | 62.7% | Apr 26, 1991 | Universal Pictures |
| 17 | Stone Cold | - | - | - | $9,151,887 | 1,729 | $9,151,887 | 100% | May 17, 1991 | Columbia Pictures |
| 18 | Dances with Wolves | - | - | - | $8,062,772 | 1,636 | $184,208,848 | 4.4% | Nov 9, 1990 | Orion Pictures |
| 19 | Drop Dead Fred | - | - | - | $8,004,411 | 933 | $13,878,334 | 57.7% | May 24, 1991 | New Line Cinema |
| 20 | Teenage Mutant Ninja Turtles II: The Secret of the Ooze | - | - | - | $7,641,394 | 2,868 | $78,656,813 | 9.7% | Mar 22, 1991 | New Line Cinema |
| 21 | Wild Hearts Can't Be Broken | - | - | - | $7,294,835 | 1,662 | $7,294,835 | 100% | May 24, 1991 | Walt Disney Studios Motion Pictures |
| 22 | New Jack City | - | - | - | $7,293,192 | 905 | $47,624,353 | 15.3% | Mar 8, 1991 | Warner Bros. |
| 23 | Mortal Thoughts | - | - | - | $6,808,163 | 1,196 | $18,784,957 | 36.2% | Apr 19, 1991 | Columbia Pictures |
| 24 | Home Alone | - | - | - | $4,114,669 | 2,173 | $285,761,243 | 1.4% | Nov 16, 1990 | Twentieth Century Fox |
| 25 | Mannequin: On the Move | - | - | - | $3,752,428 | 1,540 | $3,752,428 | 100% | May 17, 1991 | Twentieth Century Fox |
| 26 | Defending Your Life | - | - | - | $3,115,854 | 715 | $16,371,128 | 19% | Mar 22, 1991 | Warner Bros. |
| 27 | Goodfellas | - | - | - | $2,844,443 | 1,328 | $46,836,214 | 6.1% | Sep 19, 1990 | Warner Bros. |
| 28 | City Slickers | - | - | - | $2,766,002 | 2,171 | $124,033,791 | 2.2% | Jun 7, 1991 | Columbia Pictures |
| 29 | Sleeping with the Enemy | - | - | - | $2,562,723 | 1,545 | $101,599,005 | 2.5% | Feb 8, 1991 | Twentieth Century Fox |
| 30 | Eating | - | - | - | $2,081,718 | 19 | $2,100,538 | 99.1% | Nov 16, 1990 | Rainbow Releasing |
| 31 | Ju Dou | - | - | - | $1,967,488 | 39 | $1,986,433 | 99% | Mar 6, 1991 | Miramax |
| 32 | Kindergarten Cop | - | - | - | $1,856,198 | 1,937 | $91,457,688 | 2% | Dec 22, 1990 | Universal Pictures |
| 33 | Spartacus 1991 Re-release | - | - | - | $1,683,697 | 52 | $1,830,650 | 92% | Apr 26, 1991 | Universal Pictures |
| 34 | Jungle Fever | - | - | - | $1,136,168 | 844 | $32,482,682 | 3.5% | Jun 7, 1991 | Universal Pictures |
| 35 | Don't Tell Mom the Babysitter's Dead | - | - | - | $907,709 | 1,817 | $25,196,249 | 3.6% | Jun 7, 1991 | Warner Bros. |
| 36 | Rosencrantz & Guildenstern Are Dead | - | - | - | $705,286 | 18 | $739,104 | 95.4% | Feb 8, 1991 | Cinecom Pictures |
| 37 | Rich Girl | - | - | - | $561,000 | 1,058 | $561,000 | 100% | May 3, 1991 | - |
| 38 | Sweet Talker | - | - | - | $382,510 | 409 | $382,510 | 100% | May 10, 1991 | New Line Cinema |
| 39 | The Godfather Part III | - | - | - | $279,124 | 1,922 | $66,666,062 | 0.4% | Dec 25, 1990 | Paramount Pictures |
| 40 | Journey of Hope | - | - | - | $241,995 | 18 | $261,718 | 92.5% | Apr 26, 1991 | Miramax |
| 41 | The Ballad of the Sad Cafe | - | - | - | $184,890 | 1 | $184,890 | 100% | May 3, 1991 | - |
| 42 | Open Doors | - | - | - | $102,178 | 6 | $123,470 | 82.8% | Mar 8, 1991 | Orion Classics |
| 43 | Straight Out of Brooklyn | - | - | - | $88,886 | 75 | $2,712,293 | 3.3% | May 22, 1991 | The Samuel Goldwyn Company |
| 44 | True Colors | - | - | - | $84,631 | 9 | $418,807 | 20.2% | Mar 15, 1991 | Paramount Pictures |
| 45 | Auntie Danielle | - | - | - | $32,485 | 17 | $604,624 | 5.4% | May 17, 1991 | Miramax |
| 46 | Everybody's Fine | - | - | - | $29,818 | 48 | $1,745,470 | 1.7% | May 31, 1991 | Miramax |
| 47 | An Angel at My Table | - | - | - | $28,692 | 20 | $1,054,638 | 2.7% | May 17, 1991 | Fine Line Features |
| 48 | Opening Night | - | - | - | $23,488 | 1 | $23,488 | 100% | May 17, 1991 | Castle Hill Productions |
| 49 | Truly Madly Deeply | - | - | - | $11,233 | 48 | $1,554,742 | 0.7% | May 3, 1991 | The Samuel Goldwyn Company |
| 50 | Diamond Skulls | - | - | - | $3,270 | 10 | $336,811 | 1% | Jun 7, 1991 | Circle Films |
