| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Crocodile Dundee II | - | - | - | $101,865,612 | 2,837 | $109,306,210 | 93.2% | May 25, 1988 | Paramount Pictures |
| 2 | Who Framed Roger Rabbit | - | - | - | $97,985,891 | 1,598 | $156,452,370 | 62.6% | Jun 24, 1988 | Walt Disney Studios Motion Pictures |
| 3 | Coming to America | - | - | - | $94,007,418 | 2,064 | $128,152,301 | 73.4% | Jun 29, 1988 | Paramount Pictures |
| 4 | Big | - | - | - | $81,631,927 | 1,419 | $114,968,774 | 71% | Jun 3, 1988 | Twentieth Century Fox |
| 5 | Willow | - | - | - | $57,269,863 | 1,209 | $57,269,863 | 100% | May 20, 1988 | Metro-Goldwyn-Mayer (MGM) |
| 6 | Rambo III | - | - | - | $53,715,611 | 2,562 | $53,715,611 | 100% | May 25, 1988 | TriStar Pictures |
| 7 | The Great Outdoors | - | - | - | $41,455,230 | 1,430 | $41,455,230 | 100% | Jun 17, 1988 | Universal Pictures |
| 8 | Big Business | - | - | - | $40,150,487 | 1,232 | $40,150,487 | 100% | Jun 10, 1988 | Walt Disney Studios Motion Pictures |
| 9 | Bull Durham | - | - | - | $39,908,345 | 1,297 | $50,888,729 | 78.4% | Jun 17, 1988 | Orion Pictures |
| 10 | Red Heat | - | - | - | $34,994,649 | 1,892 | $34,994,648 | 100% | Jun 17, 1988 | TriStar Pictures |
| 11 | The Dead Pool | - | - | - | $30,264,572 | 1,831 | $37,903,295 | 79.8% | Jul 15, 1988 | Warner Bros. |
| 12 | Bambi 1988 Re-release | - | - | - | $26,556,670 | 1,489 | $39,047,150 | 68% | Jul 15, 1988 | Walt Disney Studios Motion Pictures |
| 13 | Beetlejuice | - | - | - | $25,842,714 | 1,582 | $73,707,461 | 35.1% | Mar 30, 1988 | Warner Bros. |
| 14 | Funny Farm | - | - | - | $25,537,221 | 1,557 | $25,537,221 | 100% | Jun 3, 1988 | Warner Bros. |
| 15 | Colors | - | - | - | $25,527,124 | 1,388 | $46,616,067 | 54.8% | Apr 15, 1988 | Orion Pictures |
| 16 | License to Drive | - | - | - | $22,433,275 | 1,225 | $22,433,275 | 100% | Jul 8, 1988 | Twentieth Century Fox |
| 17 | Die Hard | - | - | - | $22,300,845 | 1,713 | $83,008,852 | 26.9% | Jul 15, 1988 | Twentieth Century Fox |
| 18 | The Presidio | - | - | - | $20,324,096 | 1,168 | $20,324,096 | 100% | Jun 10, 1988 | Paramount Pictures |
| 19 | Friday the 13th: The New Blood | - | - | - | $19,170,001 | 1,796 | $19,170,001 | 100% | May 13, 1988 | Paramount Pictures |
| 20 | Cocktail | - | - | - | $16,474,458 | 1,462 | $78,222,753 | 21.1% | Jul 29, 1988 | Walt Disney Studios Motion Pictures |
| 21 | Midnight Run | - | - | - | $16,109,171 | 1,161 | $38,413,606 | 41.9% | Jul 22, 1988 | Universal Pictures |
| 22 | Short Circuit 2 | - | - | - | $16,045,092 | 1,348 | $21,630,088 | 74.2% | Jul 8, 1988 | TriStar Pictures |
| 23 | Arthur 2: On the Rocks | - | - | - | $14,681,192 | 1,426 | $14,681,192 | 100% | Jul 8, 1988 | Warner Bros. |
| 24 | Poltergeist III | - | - | - | $14,114,488 | 1,471 | $14,114,488 | 100% | Jun 10, 1988 | Metro-Goldwyn-Mayer (MGM) |
| 25 | Moonstruck | - | - | - | $11,026,511 | 1,178 | $80,640,528 | 13.7% | Dec 18, 1987 | Metro-Goldwyn-Mayer (MGM) |
| 26 | Big Top Pee-wee | - | - | - | $10,212,079 | 1,256 | $15,122,324 | 67.5% | Jul 22, 1988 | Paramount Pictures |
| 27 | Shakedown | - | - | - | $10,068,039 | 1,580 | $10,068,039 | 100% | May 6, 1988 | Universal Pictures |
| 28 | Caddyshack II | - | - | - | $9,765,718 | 1,556 | $11,798,302 | 82.8% | Jul 22, 1988 | Warner Bros. |
| 29 | Salsa | - | - | - | $8,892,589 | 1,125 | $8,892,589 | 100% | May 6, 1988 | Cannon Film Distributors |
| 30 | Biloxi Blues | - | - | - | $8,475,588 | 1,330 | $43,184,798 | 19.6% | Mar 25, 1988 | Universal Pictures |
| 31 | The Last Emperor | - | - | - | $7,821,078 | 877 | $43,984,230 | 17.8% | Nov 20, 1987 | Columbia Pictures |
| 32 | Phantasm II | - | - | - | $7,282,851 | 1,227 | $7,282,851 | 100% | Jul 8, 1988 | Universal Pictures |
| 33 | Good Morning, Vietnam | - | - | - | $7,194,774 | 1,598 | $123,922,370 | 5.8% | Dec 25, 1987 | Walt Disney Studios Motion Pictures |
| 34 | The Milagro Beanfield War | - | - | - | $6,813,045 | 437 | $13,825,794 | 49.3% | Mar 18, 1988 | Universal Pictures |
| 35 | Above the Law | - | - | - | $6,342,384 | 868 | $18,869,631 | 33.6% | Apr 8, 1988 | Warner Bros. |
| 36 | Stand and Deliver | - | - | - | $5,871,438 | 472 | $13,994,920 | 42% | Mar 11, 1988 | Warner Bros. |
| 37 | Return to Snowy River | - | - | - | $5,028,081 | 1,121 | $13,687,027 | 36.7% | Apr 15, 1988 | Walt Disney Studios Motion Pictures |
| 38 | Three Men and a Baby | - | - | - | $4,337,129 | 1,813 | $167,780,960 | 2.6% | Nov 25, 1987 | Walt Disney Studios Motion Pictures |
| 39 | Casual Sex? | - | - | - | $4,228,945 | 1,265 | $12,277,096 | 34.4% | Apr 22, 1988 | Universal Pictures |
| 40 | Dead Heat | - | - | - | $3,588,626 | 1,012 | $3,588,626 | 100% | May 6, 1988 | New World Pictures |
| 41 | A Fish Called Wanda | - | - | - | $3,250,196 | 1,223 | $62,493,712 | 5.2% | Jul 15, 1988 | Metro-Goldwyn-Mayer (MGM) |
| 42 | White Mischief | - | - | - | $3,059,914 | 87 | $3,107,551 | 98.5% | Apr 22, 1988 | Columbia Pictures |
| 43 | Dominick and Eugene | - | - | - | $2,673,966 | 76 | $3,076,031 | 86.9% | Mar 18, 1988 | Orion Pictures |
| 44 | The Manchurian Candidate 1988 Re-release | - | - | - | $2,643,053 | 49 | $2,757,256 | 95.9% | Feb 12, 1988 | Metro-Goldwyn-Mayer (MGM) |
| 45 | Monkey Shines | - | - | - | $2,516,592 | 1,181 | $5,344,577 | 47.1% | Jul 29, 1988 | Orion Pictures |
| 46 | The Seventh Sign | - | - | - | $2,190,847 | 1,258 | $18,875,011 | 11.6% | Apr 1, 1988 | TriStar Pictures |
| 47 | Sunset | - | - | - | $2,036,441 | 1,024 | $4,594,452 | 44.3% | Apr 29, 1988 | TriStar Pictures |
| 48 | The Moderns | - | - | - | $1,978,262 | 28 | $2,011,497 | 98.3% | Apr 15, 1988 | Alive Films |
| 49 | Stormy Monday | - | - | - | $1,729,498 | 49 | $1,791,328 | 96.5% | Apr 22, 1988 | Atlantic Releasing Corporation |
| 50 | Critters 2: The Main Course | - | - | - | $1,565,077 | 1,114 | $3,813,293 | 41% | Apr 29, 1988 | New Line Cinema |
| 51 | The New Adventures of Pippi Longstocking | - | - | - | $1,496,232 | 844 | $3,569,939 | 41.9% | Jul 29, 1988 | Columbia Pictures |
| 52 | Lady in White | - | - | - | $1,347,110 | 107 | $1,705,139 | 79% | Apr 22, 1988 | New Century |
| 53 | The Unholy | - | - | - | $1,305,834 | 1,189 | $6,337,299 | 20.6% | Apr 22, 1988 | Vestron Pictures |
| 54 | Aria | - | - | - | $1,018,105 | 34 | $1,028,679 | 99% | Mar 18, 1988 | Miramax |
| 55 | Bulletproof | - | - | - | $807,947 | 268 | $807,947 | 100% | May 13, 1988 | Universal Pictures |
| 56 | Two Moon Junction | - | - | - | $759,195 | 458 | $1,547,397 | 49.1% | Apr 29, 1988 | Lorimar Motion Pictures |
| 57 | Maniac Cop | - | - | - | $671,382 | 50 | $671,382 | 100% | May 13, 1988 | Shapiro-Glickenhaus Entertainment |
| 58 | Da | - | - | - | $627,078 | 1 | $644,532 | 97.3% | Apr 29, 1988 | FilmDallas Pictures |
| 59 | Powaqqatsi | - | - | - | $548,045 | 22 | $589,244 | 93% | Apr 29, 1988 | Cannon Film Distributors |
| 60 | The Decline of Western Civilization Part II: The Metal Years | - | - | - | $373,743 | 21 | $373,743 | 100% | Jun 3, 1988 | New Line Cinema |
| 61 | Prison | - | - | - | $345,704 | 42 | $345,704 | 100% | May 6, 1988 | New World Pictures |
| 62 | Judgment in Berlin | - | - | - | $229,556 | 81 | $229,556 | 100% | May 6, 1988 | New Line Cinema |
| 63 | A Time of Destiny | - | - | - | $225,667 | 220 | $1,212,487 | 18.6% | Apr 22, 1988 | Columbia Pictures |
| 64 | Bellman and True | - | - | - | $196,521 | 8 | $226,944 | 86.6% | Apr 1, 1988 | Island Pictures |
| 65 | Beatrice | - | - | - | $193,983 | 8 | $211,821 | 91.6% | Mar 18, 1988 | The Samuel Goldwyn Company |
| 66 | My Best Friend Is a Vampire | - | - | - | $174,380 | 170 | $174,380 | 100% | May 6, 1988 | Kings Road Entertainment |
| 67 | The Kitchen Toto | - | - | - | $101,807 | 4 | $101,807 | 100% | May 13, 1988 | Cannon Film Distributors |
| 68 | Consuming Passions | - | - | - | $95,694 | 5 | $118,206 | 81% | Apr 6, 1988 | The Samuel Goldwyn Company |
| 69 | Mr. North | - | - | - | $56,544 | 29 | $1,221,366 | 4.6% | Jul 22, 1988 | The Samuel Goldwyn Company |
| 70 | A Handful of Dust | - | - | - | $56,208 | 29 | $1,560,700 | 3.6% | Jun 24, 1988 | New Line Cinema |
| 71 | Pascali's Island | - | - | - | $41,526 | 55 | $1,451,857 | 2.9% | Jul 22, 1988 | Avenue Pictures Productions |
| 72 | A World Apart | - | - | - | $35,835 | 42 | $2,326,860 | 1.5% | Jun 17, 1988 | Atlantic Releasing Corporation |
| 73 | A Killing Affair | - | - | - | $35,000 | 4 | $35,000 | 100% | Jul 15, 1988 | Hemdale |
