| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Sea of Love | - | - | - | $49,563,905 | 1,439 | $58,571,513 | Sep 15 | Universal Pictures | false |
| 2 | Look Who's Talking | - | - | - | $48,127,418 | 1,651 | $140,088,813 | Oct 13 | TriStar Pictures | false |
| 3 | Black Rain | - | - | - | $39,326,510 | 1,760 | $46,212,055 | Sep 22 | Paramount Pictures | false |
| 4 | Uncle Buck | - | - | - | $34,708,817 | 1,835 | $66,758,538 | Aug 18 | Universal Pictures | false |
| 5 | When Harry Met Sally... | - | - | - | $26,851,603 | 1,174 | $92,823,546 | Jul 14 | Columbia Pictures | false |
| 6 | Parenthood | - | - | - | $26,663,590 | 1,399 | $100,047,830 | Aug 2 | Universal Pictures | false |
| 7 | Sex, Lies, and Videotape | - | - | - | $17,786,227 | 534 | $24,741,667 | Aug 4 | Miramax | false |
| 8 | Lethal Weapon 2 | - | - | - | $17,447,862 | 1,830 | $147,253,986 | Jul 7 | Warner Bros. | false |
| 9 | An Innocent Man | - | - | - | $16,542,748 | 1,561 | $20,047,604 | Oct 6 | Walt Disney Studios Motion Pictures | false |
| 10 | The Abyss | - | - | - | $15,324,837 | 1,538 | $54,222,310 | Aug 11 | Twentieth Century Fox | false |
| 11 | Turner & Hooch | - | - | - | $15,254,861 | 1,888 | $71,079,915 | Jul 28 | Walt Disney Studios Motion Pictures | false |
| 12 | Kickboxer | - | - | - | $14,697,005 | 973 | $14,697,005 | Sep 8 | Cannon Film Distributors | false |
| 13 | Honey, I Shrunk the Kids | - | - | - | $12,622,421 | 1,498 | $130,724,172 | Jun 23 | Walt Disney Studios Motion Pictures | false |
| 14 | Halloween 5: The Revenge of Michael Myers | - | - | - | $10,877,956 | 1,495 | $11,642,254 | Oct 13 | - | false |
| 15 | Batman | - | - | - | $10,617,931 | 2,201 | $251,188,924 | Jun 23 | Warner Bros. | false |
| 16 | The Fabulous Baker Boys | - | - | - | $10,429,476 | 860 | $18,428,904 | Oct 13 | Twentieth Century Fox | false |
| 17 | Dead Poets Society | - | - | - | $9,885,756 | 1,109 | $95,860,116 | Jun 2 | Walt Disney Studios Motion Pictures | false |
| 18 | Next of Kin | - | - | - | $9,662,999 | 1,358 | $15,942,628 | Oct 20 | Warner Bros. | false |
| 19 | Indiana Jones and the Last Crusade | - | - | - | $8,493,887 | 2,327 | $197,171,806 | May 24 | Paramount Pictures | false |
| 20 | Johnny Handsome | - | - | - | $7,237,794 | 813 | $7,237,794 | Sep 29 | TriStar Pictures | false |
| 21 | The Package | - | - | - | $6,559,515 | 460 | $10,647,219 | Aug 25 | Orion Pictures | false |
| 22 | Shocker | - | - | - | $5,925,295 | 1,795 | $16,554,699 | Oct 27 | Universal Pictures | false |
| 23 | Shirley Valentine | - | - | - | $5,849,956 | 8 | $6,056,912 | Sep 1 | Paramount Pictures | false |
| 24 | Gross Anatomy | - | - | - | $5,806,200 | 1,080 | $11,604,598 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 25 | Casualties of War | - | - | - | $5,175,471 | 1,487 | $18,671,317 | Aug 18 | Columbia Pictures | false |
| 26 | Relentless | - | - | - | $4,870,886 | 836 | $6,985,999 | Sep 1 | New Line Cinema | false |
| 27 | The Bear | - | - | - | $4,860,066 | 1,056 | $31,753,898 | Oct 27 | TriStar Pictures | false |
| 28 | A Dry White Season | - | - | - | $3,766,879 | 316 | $3,766,879 | Sep 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 29 | Crimes and Misdemeanors | - | - | - | $3,582,797 | 525 | $18,254,702 | Oct 13 | Orion Pictures | false |
| 30 | Old Gringo | - | - | - | $3,574,256 | 237 | $3,574,256 | Oct 6 | Columbia Pictures | false |
| 31 | Fat Man and Little Boy | - | - | - | $3,563,162 | 843 | $3,563,162 | Oct 20 | Paramount Pictures | false |
| 32 | A Nightmare on Elm Street: The Dream Child | - | - | - | $3,427,838 | 1,902 | $22,168,359 | Aug 11 | New Line Cinema | false |
| 33 | In Country | - | - | - | $3,034,808 | 606 | $3,531,971 | Sep 15 | Warner Bros. | false |
| 34 | Millennium | - | - | - | $2,748,073 | 488 | $5,777,099 | Aug 25 | Twentieth Century Fox | false |
| 35 | Ghostbusters II | - | - | - | $2,493,944 | 2,410 | $112,494,738 | Jun 16 | Columbia Pictures | false |
| 36 | Immediate Family | - | - | - | $2,184,328 | 836 | $5,932,613 | Oct 27 | Columbia Pictures | false |
| 37 | Worth Winning | - | - | - | $1,980,445 | 1,260 | $3,690,328 | Oct 27 | Twentieth Century Fox | false |
| 38 | Breaking In | - | - | - | $1,877,618 | 400 | $1,877,618 | Oct 13 | The Samuel Goldwyn Company | false |
| 39 | Bloodfist | - | - | - | $1,770,082 | 54 | $1,770,082 | Sep 22 | Concorde Pictures | false |
| 40 | Romero | - | - | - | $1,297,668 | 51 | $1,316,495 | Aug 25 | Four Square | false |
| 41 | The Music Teacher | - | - | - | $1,057,934 | 19 | $1,086,894 | Jul 7 | Orion Classics | false |
| 42 | Dad | - | - | - | $759,181 | 1,188 | $22,103,037 | Oct 27 | Universal Pictures | false |
| 43 | Distant Voices, Still Lives | - | - | - | $673,026 | 22 | $688,329 | Jul 28 | Avenue Pictures Productions | false |
| 44 | Erik the Viking | - | - | - | $500,970 | 269 | $1,932,642 | Sep 22 | Orion Pictures | false |
| 45 | Kill Me Again | - | - | - | $283,694 | 221 | $283,694 | Oct 27 | - | false |
| 46 | Heavy Petting | - | - | - | $272,371 | 11 | $272,371 | Sep 22 | Skouras Pictures | false |
| 47 | The Big Picture | - | - | - | $117,463 | 8 | $117,463 | Sep 15 | Columbia Pictures | false |
| 48 | When the Whales Came | - | - | - | $73,131 | 10 | $73,131 | Oct 20 | Twentieth Century Fox | false |
| 49 | Thelonious Monk: Straight, No Chaser | - | - | - | $57,968 | 11 | $518,918 | Oct 1 | Warner Bros. | false |
| 50 | Drugstore Cowboy | - | - | - | $48,432 | 87 | $4,729,352 | Oct 6 | Avenue Pictures Productions | false |
| 51 | Animal Behavior | - | - | - | $33,935 | 24 | $41,526 | Oct 27 | Miramax | false |
| 52 | Apartment Zero | - | - | - | $29,017 | 22 | $1,267,578 | Sep 15 | Skouras Pictures | false |
| 53 | Weapons of the Spirit | - | - | - | $9,951 | 4 | $232,981 | Sep 1 | First Run | false |
| 54 | For All Mankind | - | - | - | $4,733 | 9 | $770,132 | Nov 1 | Apollo Associates | false |
