| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Godzilla vs. Kong | - | - | - | $76,961,746 | 3,084 | $100,916,094 | 76.3% | Mar 31, 2021 | Warner Bros. |
| 2 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | - | - | - | $35,446,695 | 2,087 | $49,505,008 | 71.6% | Apr 23, 2021 | FUNimation Entertainment |
| 3 | Mortal Kombat | - | - | - | $25,150,000 | 3,114 | $42,326,031 | 59.4% | Apr 23, 2021 | Warner Bros. |
| 4 | Nobody | - | - | - | $15,272,410 | 2,567 | $27,568,035 | 55.4% | Mar 26, 2021 | Universal Pictures |
| 5 | The Unholy | - | - | - | $13,299,436 | 2,057 | $15,532,137 | 85.6% | Apr 2, 2021 | Screen Gems |
| 6 | Raya and the Last Dragon | - | - | - | $12,065,296 | 2,375 | $54,723,032 | 22% | Mar 5, 2021 | Walt Disney Studios Motion Pictures |
| 7 | Tom & Jerry | - | - | - | $5,642,476 | 2,563 | $46,536,687 | 12.1% | Feb 26, 2021 | Warner Bros. |
| 8 | Voyagers | - | - | - | $3,103,874 | 1,996 | $3,149,935 | 98.5% | Apr 9, 2021 | Lionsgate |
| 9 | The Girl Who Believes in Miracles | - | - | - | $2,795,975 | 1,012 | $3,163,362 | 88.4% | Apr 2, 2021 | Atlas Distribution Company |
| 10 | The Courier | - | - | - | $2,534,800 | 1,641 | $6,613,432 | 38.3% | Mar 19, 2021 | Roadside Attractions |
| 11 | Separation | - | - | - | $2,080,288 | 1,911 | $4,509,143 | 46.1% | Apr 30, 2021 | Open Road Films (II) |
| 12 | The Croods: A New Age | - | - | - | $1,513,967 | 2,211 | $58,568,815 | 2.6% | Nov 25, 2020 | Universal Pictures |
| 13 | Chaos Walking | - | - | - | $1,461,149 | 2,132 | $13,287,908 | 11% | Mar 5, 2021 | Lionsgate |
| 14 | Together Together | - | - | - | $1,081,631 | 665 | $1,437,938 | 75.2% | Apr 23, 2021 | Bleecker Street Media |
| 15 | In the Earth | - | - | - | $1,070,607 | 571 | $1,113,723 | 96.1% | Apr 16, 2021 | Neon |
| 16 | Minari | - | - | - | $930,360 | 912 | $3,110,580 | 29.9% | Feb 12, 2021 | A24 |
| 17 | Scott Pilgrim vs. the World 10th Anniversary (2021 Re-release) | - | - | - | $882,300 | 448 | $1,867,625 | 47.2% | - | Universal Pictures |
| 18 | The Marksman | - | - | - | $711,871 | 2,018 | $15,566,093 | 4.6% | Jan 15, 2021 | Open Road Films (II) |
| 19 | French Exit | - | - | - | $655,873 | 493 | $741,895 | 88.4% | Feb 12, 2021 | Sony Pictures Classics |
| 20 | The Father | - | - | - | $645,991 | 933 | $2,122,771 | 30.4% | Feb 26, 2021 | Sony Pictures Classics |
| 21 | Wonder Woman 1984 | - | - | - | $508,565 | 2,218 | $46,801,036 | 1.1% | Dec 25, 2020 | Warner Bros. |
| 22 | Promising Young Woman | - | - | - | $455,635 | 1,448 | $6,460,965 | 7.1% | Dec 25, 2020 | Focus Features |
| 23 | 2021 Oscar Nominated Short Films: Live Action | - | - | - | $437,077 | 184 | $443,050 | 98.7% | Apr 2, 2021 | Magnolia Pictures |
| 24 | Four Good Days | - | - | - | $354,670 | 489 | $837,849 | 42.3% | Apr 30, 2021 | Vertical Entertainment |
| 25 | The Little Things | - | - | - | $285,154 | 2,206 | $15,342,746 | 1.9% | Jan 29, 2021 | Warner Bros. |
| 26 | Boogie | - | - | - | $256,675 | 1,272 | $4,178,620 | 6.1% | Mar 5, 2021 | Focus Features |
| 27 | Wrong Turn | - | - | - | $250,796 | 259 | $1,251,184 | 20% | Jan 26, 2021 | Saban Films |
| 28 | Judas and the Black Messiah | - | - | - | $200,653 | 1,906 | $5,478,009 | 3.7% | Feb 12, 2021 | Warner Bros. |
| 29 | Lamb of God: The Concert Film | - | - | - | $168,095 | 138 | $744,813 | 22.6% | Mar 12, 2021 | Excel Entertainment |
| 30 | Monster Hunter | - | - | - | $160,048 | 1,817 | $15,162,470 | 1.1% | Dec 18, 2020 | Screen Gems |
| 31 | The War with Grandpa | - | - | - | $149,772 | 2,365 | $21,277,892 | 0.7% | Oct 9, 2020 | 101 Studios |
| 32 | SAS: Rise of the Black Swan | - | - | - | $146,329 | 189 | $146,329 | 100% | Apr 16, 2021 | Vertical Entertainment |
| 33 | The Truffle Hunters | - | - | - | $141,068 | 105 | $521,202 | 27.1% | Mar 5, 2021 | Sony Pictures Classics |
| 34 | Held | - | - | - | $127,228 | 129 | $142,817 | 89.1% | Apr 9, 2021 | Magnolia Pictures |
| 35 | Limbo | - | - | - | $103,790 | 213 | $224,405 | 46.3% | Apr 30, 2021 | Focus Features |
| 36 | The Resort | - | - | - | $99,496 | 114 | $191,996 | 51.8% | Apr 30, 2021 | Vertical Entertainment |
| 37 | News of the World | - | - | - | $92,145 | 1,986 | $12,668,325 | 0.7% | Dec 25, 2020 | Universal Pictures |
| 38 | Shiva Baby | - | - | - | $89,151 | 27 | $159,294 | 56% | Apr 2, 2021 | Utopia |
| 39 | Cliff Walkers | - | - | - | $66,132 | 65 | $152,972 | 43.2% | Apr 30, 2021 | CMC Pictures |
| 40 | Dutch | - | - | - | $61,585 | 202 | $404,371 | 15.2% | Mar 12, 2021 | Faith Media Distribution |
| 41 | Six Minutes to Midnight | - | - | - | $60,670 | 145 | $132,500 | 45.8% | Mar 26, 2021 | IFC Films |
| 42 | City of Lies | - | - | - | $53,703 | 502 | $572,493 | 9.4% | Mar 19, 2021 | Saban Films |
| 43 | Gunda | - | - | - | $32,888 | 35 | $115,691 | 28.4% | Apr 16, 2021 | Neon |
| 44 | Tenet | - | - | - | $32,230 | 2,930 | $58,504,105 | <0.1% | Sep 3, 2020 | Warner Bros. |
| 45 | Monday | - | - | - | $30,685 | 54 | $30,932 | 99.2% | Apr 16, 2021 | IFC Films |
| 46 | Trigger Point | - | - | - | $29,262 | 77 | $29,262 | 100% | Apr 16, 2021 | Screen Media Films |
| 47 | Jakob's Wife | - | - | - | $27,588 | 101 | $27,588 | 100% | Apr 16, 2021 | RLJ Entertainment |
| 48 | Moffie | - | - | - | $24,520 | 51 | $24,520 | 100% | Apr 9, 2021 | IFC Films |
| 49 | We Broke Up | - | - | - | $15,063 | 35 | $15,063 | 100% | Apr 16, 2021 | Vertical Entertainment |
| 50 | Counter Column | - | - | - | $14,864 | 7 | $32,323 | 46% | Oct 16, 2020 | Not That Kind of Movie Productions |
| 51 | Long Weekend | - | - | - | $12,719 | 821 | $1,018,532 | 1.2% | Mar 12, 2021 | Stage 6 Films |
| 52 | 100% Wolf | - | - | - | $11,478 | 124 | $658,764 | 1.7% | Oct 9, 2020 | Viva Pictures |
| 53 | About Endlessness | - | - | - | $11,440 | 17 | $51,386 | 22.3% | Apr 30, 2021 | Magnolia Pictures |
| 54 | Senior Moment | - | - | - | $9,913 | 57 | $41,598 | 23.8% | Mar 26, 2021 | Screen Media Films |
| 55 | The Boonies | - | - | - | $5,891 | 2 | $6,887 | 85.5% | Mar 31, 2021 | Indican Pictures |
| 56 | Blithe Spirit | - | - | - | $5,113 | 239 | $282,500 | 1.8% | Feb 19, 2021 | IFC Films |
| 57 | Blood Brothers: Civil War | - | - | - | $5,089 | 2 | $5,191 | 98% | Apr 2, 2021 | Indican Pictures |
| 58 | Bill Traylor: Chasing Ghosts | - | - | - | $4,143 | 2 | $4,504 | 92% | Apr 16, 2021 | Kino Lorber |
| 59 | Endless Rain | - | - | - | $3,398 | 14 | $7,334 | 46.3% | Apr 30, 2021 | Sony Pictures Releasing |
| 60 | A Writer's Odyssey | - | - | - | $3,240 | 117 | $160,013 | 2% | Feb 12, 2021 | CMC Pictures |
| 61 | Slalom | - | - | - | $2,796 | 4 | $2,788 | 100.3% | Apr 9, 2021 | Kino Lorber |
| 62 | Mystery of the Kingdom of God | - | - | - | $2,174 | 106 | $17,316 | 12.6% | Mar 26, 2021 | Atlas Distribution Company |
| 63 | Things Don't Stay Fixed | - | - | - | $1,610 | 3 | $5,430 | 29.7% | Mar 26, 2021 | Indican Pictures |
| 64 | Bang! Bang! | - | - | - | $1,348 | 1 | $6,390 | 21.1% | Oct 23, 2020 | Indican Pictures |
| 65 | Last Call | - | - | - | $1,313 | 110 | $48,144 | 2.7% | Mar 19, 2021 | IFC Films |
| 66 | The Mauritanian | - | - | - | $812 | 287 | $836,536 | <0.1% | Feb 12, 2021 | STX Entertainment |
| 67 | The Incredible 25th Year of Mitzi Bearclaw | - | - | - | $695 | 2 | $12,486 | 5.6% | Feb 12, 2021 | Indican Pictures |
| 68 | Come True | - | - | - | $600 | 96 | $62,080 | 1% | Mar 12, 2021 | IFC Films |
| 69 | Safer at Home | - | - | - | $516 | 79 | $95,643 | 0.5% | Feb 26, 2021 | Vertical Entertainment |
| 70 | Supernova | - | - | - | $464 | 330 | $234,220 | 0.2% | Jan 29, 2021 | Bleecker Street Media |
| 71 | No Place | - | - | - | $363 | 1 | $4,194 | 8.7% | Mar 5, 2021 | Indican Pictures |
| 72 | The Vigil | - | - | - | $332 | 55 | $50,439 | 0.7% | Feb 26, 2021 | IFC Films |
| 73 | My Zoe | - | - | - | $281 | 237 | $52,733 | 0.5% | Feb 26, 2021 | Blue Fox Entertainment |
| 74 | Stray | - | - | - | $271 | 17 | $13,325 | 2% | Mar 5, 2021 | Magnolia Pictures |
| 75 | My Salinger Year | - | - | - | $270 | 123 | $54,730 | 0.5% | Mar 5, 2021 | IFC Films |
| 76 | The World to Come | - | - | - | $207 | 277 | $116,143 | 0.2% | Feb 12, 2021 | Bleecker Street Media |
| 77 | First Signal | - | - | - | $170 | 1 | $880 | 19.3% | Mar 26, 2021 | The Ashton Times |
| 78 | The Shade Shepherd | - | - | - | $120 | 1 | $4,409 | 2.7% | Oct 16, 2020 | Indican Pictures |
| 79 | Abandoned: Angelique's Isle | - | - | - | $100 | 1 | $6,055 | 1.7% | Feb 19, 2021 | Indican Pictures |
