| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Teenage Mutant Ninja Turtles II: The Secret of the Ooze | - | - | - | $43,560,969 | 2,868 | $78,656,813 | 55.4% | Mar 22, 1991 | New Line Cinema |
| 2 | What About Bob? | - | - | - | $40,619,676 | 1,805 | $63,707,829 | 63.8% | May 17, 1991 | Walt Disney Studios Motion Pictures |
| 3 | Backdraft | - | - | - | $40,098,900 | 1,983 | $77,868,585 | 51.5% | May 24, 1991 | Universal Pictures |
| 4 | Out for Justice | - | - | - | $39,673,161 | 2,010 | $39,673,161 | 100% | Apr 12, 1991 | Warner Bros. |
| 5 | The Silence of the Lambs | - | - | - | $37,880,666 | 1,642 | $130,742,922 | 29% | Feb 14, 1991 | Orion Pictures |
| 6 | Dances with Wolves | - | - | - | $29,117,521 | 1,636 | $184,208,848 | 15.8% | Nov 9, 1990 | Orion Pictures |
| 7 | Oscar | - | - | - | $23,562,716 | 1,391 | $23,562,716 | 100% | Apr 26, 1991 | Walt Disney Studios Motion Pictures |
| 8 | New Jack City | - | - | - | $21,136,415 | 905 | $47,624,353 | 44.4% | Mar 8, 1991 | Warner Bros. |
| 9 | F/X2 | - | - | - | $21,082,165 | 1,502 | $21,082,165 | 100% | May 10, 1991 | Orion Pictures |
| 10 | Mortal Thoughts | - | - | - | $18,784,957 | 1,196 | $18,784,957 | 100% | Apr 19, 1991 | Columbia Pictures |
| 11 | Thelma & Louise | - | - | - | $17,974,696 | 1,180 | $45,360,915 | 39.6% | May 24, 1991 | Metro-Goldwyn-Mayer (MGM) |
| 12 | City Slickers | - | - | - | $16,596,012 | 2,171 | $124,033,791 | 13.4% | Jun 7, 1991 | Columbia Pictures |
| 13 | Sleeping with the Enemy | - | - | - | $16,467,731 | 1,545 | $101,599,005 | 16.2% | Feb 8, 1991 | 20th Century Fox |
| 14 | Defending Your Life | - | - | - | $16,169,340 | 715 | $16,371,128 | 98.8% | Mar 22, 1991 | Warner Bros. |
| 15 | Home Alone | - | - | - | $15,651,484 | 2,173 | $285,761,243 | 5.5% | Nov 16, 1990 | 20th Century Fox |
| 16 | Switch | - | - | - | $15,545,943 | 1,013 | $15,545,943 | 100% | May 10, 1991 | Warner Bros. |
| 17 | A Kiss Before Dying | - | - | - | $15,429,177 | 1,546 | $15,429,177 | 100% | Apr 26, 1991 | Universal Pictures |
| 18 | Soapdish | - | - | - | $15,217,436 | 1,275 | $36,489,888 | 41.7% | May 31, 1991 | Paramount Pictures |
| 19 | Toy Soldiers | - | - | - | $15,073,942 | 1,358 | $15,073,942 | 100% | Apr 26, 1991 | TriStar Pictures |
| 20 | Madonna: Truth or Dare | - | - | - | $15,012,935 | 652 | $15,012,935 | 100% | May 10, 1991 | Miramax |
| 21 | Only the Lonely | - | - | - | $14,956,811 | 1,553 | $21,830,957 | 68.5% | May 24, 1991 | 20th Century Fox |
| 22 | Hudson Hawk | - | - | - | $14,841,413 | 2,072 | $17,218,080 | 86.2% | May 24, 1991 | TriStar Pictures |
| 23 | The Marrying Man | - | - | - | $12,454,768 | 1,343 | $12,454,768 | 100% | Apr 5, 1991 | Walt Disney Studios Motion Pictures |
| 24 | One Good Cop | - | - | - | $11,276,846 | 1,454 | $11,276,846 | 100% | May 3, 1991 | Walt Disney Studios Motion Pictures |
| 25 | Class Action | - | - | - | $11,219,120 | 1,132 | $24,277,858 | 46.2% | Mar 15, 1991 | 20th Century Fox |
| 26 | A Rage in Harlem | - | - | - | $10,438,504 | 545 | $10,438,504 | 100% | May 3, 1991 | Miramax |
| 27 | Drop Dead Fred | - | - | - | $9,272,371 | 933 | $13,878,334 | 66.8% | May 24, 1991 | New Line Cinema |
| 28 | Stone Cold | - | - | - | $9,151,887 | 1,729 | $9,151,887 | 100% | May 17, 1991 | Columbia Pictures |
| 29 | Career Opportunities | - | - | - | $8,955,551 | 1,440 | $11,336,986 | 79% | Mar 29, 1991 | Universal Pictures |
| 30 | The Five Heartbeats | - | - | - | $7,723,808 | 862 | $8,750,400 | 88.3% | Mar 29, 1991 | 20th Century Fox |
| 31 | Wild Hearts Can't Be Broken | - | - | - | $7,294,835 | 1,662 | $7,294,835 | 100% | May 24, 1991 | Walt Disney Studios Motion Pictures |
| 32 | The Hard Way | - | - | - | $7,115,892 | 1,629 | $25,895,485 | 27.5% | Mar 8, 1991 | Universal Pictures |
| 33 | Jungle Fever | - | - | - | $6,817,008 | 844 | $32,482,682 | 21% | Jun 7, 1991 | Universal Pictures |
| 34 | The Doors | - | - | - | $5,534,303 | 1,236 | $34,416,893 | 16.1% | Mar 1, 1991 | TriStar Pictures |
| 35 | Don't Tell Mom the Babysitter's Dead | - | - | - | $5,446,254 | 1,817 | $25,196,249 | 21.6% | Jun 7, 1991 | Warner Bros. |
| 36 | The Object of Beauty | - | - | - | $5,136,759 | 18 | $5,136,759 | 100% | Apr 12, 1991 | Avenue Pictures Productions |
| 37 | Kindergarten Cop | - | - | - | $4,915,206 | 1,937 | $91,457,688 | 5.4% | Dec 22, 1990 | Universal Pictures |
| 38 | The Perfect Weapon | - | - | - | $4,895,902 | 1,229 | $14,061,361 | 34.8% | Mar 15, 1991 | Paramount Pictures |
| 39 | Mannequin: On the Move | - | - | - | $3,752,428 | 1,540 | $3,752,428 | 100% | May 17, 1991 | 20th Century Fox |
| 40 | Awakenings | - | - | - | $3,630,528 | 1,330 | $52,096,475 | 7% | Dec 22, 1990 | Columbia Pictures |
| 41 | Guilty by Suspicion | - | - | - | $3,132,676 | 817 | $9,480,198 | 33% | Mar 15, 1991 | Warner Bros. |
| 42 | GoodFellas | - | - | - | $2,844,443 | 1,328 | $46,836,214 | 6.1% | Sep 19, 1990 | Warner Bros. |
| 43 | The Long Walk Home | - | - | - | $2,808,331 | 272 | $4,873,620 | 57.6% | Dec 22, 1990 | Miramax |
| 44 | The Nasty Girl | - | - | - | $2,250,995 | 40 | $2,281,569 | 98.7% | Oct 26, 1990 | Miramax |
| 45 | Eating | - | - | - | $2,081,718 | 19 | $2,100,538 | 99.1% | Nov 16, 1990 | Rainbow Releasing |
| 46 | Ju Dou | - | - | - | $1,967,488 | 39 | $1,986,433 | 99% | Mar 6, 1991 | Miramax |
| 47 | Spartacus 1991 Re-release | - | - | - | $1,830,650 | 52 | $1,830,650 | 100% | Apr 26, 1991 | Universal Pictures |
| 48 | The Unborn | - | - | - | $1,063,173 | 67 | $1,159,578 | 91.7% | Mar 29, 1991 | Concorde Pictures |
| 49 | The Godfather Part III | - | - | - | $920,156 | 1,922 | $66,666,062 | 1.4% | Dec 25, 1990 | Paramount Pictures |
| 50 | Rosencrantz & Guildenstern Are Dead | - | - | - | $705,286 | 18 | $739,104 | 95.4% | Feb 8, 1991 | Cinecom Pictures |
| 51 | Rich Girl | - | - | - | $561,000 | 1,058 | $561,000 | 100% | May 3, 1991 | Studio Three Film Corporation |
| 52 | Sweet Talker | - | - | - | $382,510 | 409 | $382,510 | 100% | May 10, 1991 | New Line Cinema |
| 53 | Iron & Silk | - | - | - | $337,765 | 14 | $356,077 | 94.9% | Feb 15, 1991 | Miramax |
| 54 | Talent for the Game | - | - | - | $336,396 | 60 | $336,396 | 100% | Apr 26, 1991 | Paramount Pictures |
| 55 | True Colors | - | - | - | $330,027 | 9 | $418,807 | 78.8% | Mar 15, 1991 | Paramount Pictures |
| 56 | Journey of Hope | - | - | - | $261,718 | 18 | $261,718 | 100% | Apr 26, 1991 | Miramax |
| 57 | The Ballad of the Sad Cafe | - | - | - | $184,890 | 1 | $184,890 | 100% | May 3, 1991 | Angelika Films |
| 58 | Open Doors | - | - | - | $102,178 | 6 | $123,470 | 82.8% | Mar 8, 1991 | Orion Classics |
| 59 | Straight Out of Brooklyn | - | - | - | $88,886 | 75 | $2,712,293 | 3.3% | May 22, 1991 | The Samuel Goldwyn Company |
| 60 | Impromptu | - | - | - | $76,720 | 166 | $4,076,211 | 1.9% | Apr 12, 1991 | Hemdale |
| 61 | Auntie Danielle | - | - | - | $32,485 | 17 | $604,624 | 5.4% | May 17, 1991 | Miramax |
| 62 | Everybody's Fine | - | - | - | $29,818 | 48 | $1,745,470 | 1.7% | May 31, 1991 | Miramax |
| 63 | An Angel at My Table | - | - | - | $28,692 | 20 | $1,054,638 | 2.7% | May 17, 1991 | Fine Line Features |
| 64 | Thousand Pieces of Gold | - | - | - | $23,647 | 10 | $717,772 | 3.3% | Apr 26, 1991 | Greycat Films |
| 65 | Opening Night | - | - | - | $23,488 | 1 | $23,488 | 100% | May 17, 1991 | Castle Hill Productions |
| 66 | Daddy Nostalgia | - | - | - | $23,194 | 29 | $1,108,429 | 2.1% | Apr 12, 1991 | Avenue Pictures Productions |
| 67 | Dark Obsession | - | - | - | $19,620 | 10 | $336,811 | 5.8% | Jun 7, 1991 | Circle Films |
| 68 | Truly Madly Deeply | - | - | - | $11,233 | 48 | $1,554,742 | 0.7% | May 3, 1991 | The Samuel Goldwyn Company |
