| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Coming to America | - | - | - | $103,868,557 | 2,064 | $128,152,301 | 81.1% | Jun 29, 1988 | Paramount Pictures |
| 2 | Who Framed Roger Rabbit | - | - | - | $86,983,235 | 1,598 | $156,452,370 | 55.6% | Jun 24, 1988 | Walt Disney Studios Motion Pictures |
| 3 | Big | - | - | - | $40,754,795 | 1,419 | $114,968,774 | 35.4% | Jun 3, 1988 | Twentieth Century Fox |
| 4 | The Dead Pool | - | - | - | $37,903,295 | 1,831 | $37,903,295 | 100% | Jul 15, 1988 | Warner Bros. |
| 5 | Die Hard | - | - | - | $33,933,763 | 1,713 | $83,008,852 | 40.9% | Jul 15, 1988 | Twentieth Century Fox |
| 6 | Cocktail | - | - | - | $33,830,604 | 1,462 | $78,222,753 | 43.2% | Jul 29, 1988 | Walt Disney Studios Motion Pictures |
| 7 | Bambi 1988 Re-release | - | - | - | $31,100,225 | 1,489 | $39,047,150 | 79.6% | Jul 15, 1988 | Walt Disney Studios Motion Pictures |
| 8 | Crocodile Dundee II | - | - | - | $27,189,837 | 2,837 | $109,306,210 | 24.9% | May 25, 1988 | Paramount Pictures |
| 9 | Bull Durham | - | - | - | $26,239,710 | 1,297 | $50,888,729 | 51.6% | Jun 17, 1988 | Orion Pictures |
| 10 | Midnight Run | - | - | - | $23,380,191 | 1,161 | $38,413,606 | 60.9% | Jul 22, 1988 | Universal Pictures |
| 11 | The Great Outdoors | - | - | - | $22,619,942 | 1,430 | $41,455,230 | 54.6% | Jun 17, 1988 | Universal Pictures |
| 12 | License to Drive | - | - | - | $22,433,275 | 1,225 | $22,433,275 | 100% | Jul 8, 1988 | Twentieth Century Fox |
| 13 | Short Circuit 2 | - | - | - | $21,630,088 | 1,348 | $21,630,088 | 100% | Jul 8, 1988 | TriStar Pictures |
| 14 | Big Business | - | - | - | $17,087,127 | 1,232 | $40,150,487 | 42.6% | Jun 10, 1988 | Walt Disney Studios Motion Pictures |
| 15 | Willow | - | - | - | $16,172,380 | 1,209 | $57,269,863 | 28.2% | May 20, 1988 | Metro-Goldwyn-Mayer (MGM) |
| 16 | Big Top Pee-wee | - | - | - | $15,122,324 | 1,256 | $15,122,324 | 100% | Jul 22, 1988 | Paramount Pictures |
| 17 | Red Heat | - | - | - | $14,706,474 | 1,892 | $34,994,648 | 42% | Jun 17, 1988 | TriStar Pictures |
| 18 | Arthur 2: On the Rocks | - | - | - | $14,681,192 | 1,426 | $14,681,192 | 100% | Jul 8, 1988 | Warner Bros. |
| 19 | A Fish Called Wanda | - | - | - | $12,654,673 | 1,223 | $62,493,712 | 20.2% | Jul 15, 1988 | Metro-Goldwyn-Mayer (MGM) |
| 20 | Caddyshack II | - | - | - | $11,798,302 | 1,556 | $11,798,302 | 100% | Jul 22, 1988 | Warner Bros. |
| 21 | Phantasm II | - | - | - | $7,282,851 | 1,227 | $7,282,851 | 100% | Jul 8, 1988 | Universal Pictures |
| 22 | Rambo III | - | - | - | $5,977,156 | 2,562 | $53,715,611 | 11.1% | May 25, 1988 | TriStar Pictures |
| 23 | The Presidio | - | - | - | $5,933,412 | 1,168 | $20,324,096 | 29.2% | Jun 10, 1988 | Paramount Pictures |
| 24 | Monkey Shines | - | - | - | $5,344,577 | 1,181 | $5,344,577 | 100% | Jul 29, 1988 | Orion Pictures |
| 25 | The Blob | - | - | - | $4,183,126 | 1,081 | $8,247,943 | 50.7% | Aug 5, 1988 | TriStar Pictures |
| 26 | Funny Farm | - | - | - | $4,089,215 | 1,557 | $25,537,221 | 16% | Jun 3, 1988 | Warner Bros. |
| 27 | The New Adventures of Pippi Longstocking | - | - | - | $3,569,939 | 844 | $3,569,939 | 100% | Jul 29, 1988 | Columbia Pictures |
| 28 | The Rescue | - | - | - | $3,420,078 | 1,275 | $5,855,392 | 58.4% | Aug 5, 1988 | Walt Disney Studios Motion Pictures |
| 29 | Wings of Desire | - | - | - | $3,179,500 | 29 | $3,210,139 | 99% | Apr 29, 1988 | Orion Classics |
| 30 | Poltergeist III | - | - | - | $2,946,702 | 1,471 | $14,114,488 | 20.9% | Jun 10, 1988 | Metro-Goldwyn-Mayer (MGM) |
| 31 | Vibes | - | - | - | $1,883,811 | 1,003 | $1,883,811 | 100% | Aug 5, 1988 | Columbia Pictures |
| 32 | Young Guns | - | - | - | $1,619,928 | 1,416 | $45,661,556 | 3.5% | Aug 12, 1988 | Twentieth Century Fox |
| 33 | Tucker: The Man and His Dream | - | - | - | $773,515 | 720 | $19,652,638 | 3.9% | Aug 12, 1988 | Paramount Pictures |
| 34 | Clean and Sober | - | - | - | $612,420 | 675 | $8,674,093 | 7.1% | Aug 12, 1988 | Warner Bros. |
| 35 | Mac and Me | - | - | - | $490,120 | 1,317 | $6,424,112 | 7.6% | Aug 12, 1988 | Orion Pictures |
| 36 | Bellman and True | - | - | - | $196,521 | 8 | $226,944 | 86.6% | Apr 1, 1988 | Island Pictures |
| 37 | The Last Temptation of Christ | - | - | - | $101,037 | 123 | $8,373,585 | 1.2% | Aug 12, 1988 | Universal Pictures |
| 38 | Mr. North | - | - | - | $56,544 | 29 | $1,221,366 | 4.6% | Jul 22, 1988 | The Samuel Goldwyn Company |
| 39 | Pascali's Island | - | - | - | $41,526 | 55 | $1,451,857 | 2.9% | Jul 22, 1988 | Avenue Pictures Productions |
| 40 | A Killing Affair | - | - | - | $35,000 | 4 | $35,000 | 100% | Jul 15, 1988 | Hemdale |
