| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 37 | Batman | - | - | - | $5,523,210 | 2,201 | $251,188,924 | Jun 23 | Warner Bros. | false |
| 35 | Lethal Weapon 2 | - | - | - | $6,147,064 | 1,830 | $147,253,986 | Jul 7 | Warner Bros. | false |
| 1 | Look Who's Talking | - | - | - | $113,455,801 | 1,651 | $140,088,813 | Oct 13 | TriStar Pictures | false |
| 31 | Honey, I Shrunk the Kids | - | - | - | $7,096,618 | 1,498 | $130,724,172 | Jun 23 | Walt Disney Studios Motion Pictures | false |
| 2 | Back to the Future Part II | - | - | - | $93,592,195 | 2,107 | $118,450,002 | Nov 22 | Universal Pictures | false |
| 55 | Ghostbusters II | - | - | - | $1,139,671 | 2,410 | $112,494,738 | Jun 16 | Columbia Pictures | false |
| 53 | Driving Miss Daisy | - | - | - | $1,300,610 | 1,668 | $106,593,296 | Dec 15 | Warner Bros. | false |
| 21 | Parenthood | - | - | - | $14,406,860 | 1,399 | $100,047,830 | Aug 2 | Universal Pictures | false |
| 22 | When Harry Met Sally... | - | - | - | $13,260,711 | 1,174 | $92,823,546 | Jul 14 | Columbia Pictures | false |
| 7 | The War of the Roses | - | - | - | $38,970,601 | 1,559 | $86,888,546 | Dec 8 | Twentieth Century Fox | false |
| 5 | The Little Mermaid | - | - | - | $45,041,339 | 1,533 | $84,355,863 | Nov 17 | Walt Disney Studios Motion Pictures | false |
| 6 | Steel Magnolias | - | - | - | $41,817,324 | 1,372 | $83,759,091 | Nov 17 | TriStar Pictures | false |
| 4 | National Lampoon's Christmas Vacation | - | - | - | $53,751,580 | 1,950 | $71,319,526 | Dec 1 | Warner Bros. | false |
| 33 | Turner & Hooch | - | - | - | $6,435,607 | 1,888 | $71,079,915 | Jul 28 | Walt Disney Studios Motion Pictures | false |
| 59 | Born on the Fourth of July | - | - | - | $749,232 | 1,434 | $70,001,698 | Dec 22 | Universal Pictures | false |
| 20 | Uncle Buck | - | - | - | $15,322,555 | 1,835 | $66,758,538 | Aug 18 | Universal Pictures | false |
| 17 | Tango & Cash | - | - | - | $17,474,496 | 1,575 | $63,408,614 | Dec 22 | Warner Bros. | false |
| 3 | Harlem Nights | - | - | - | $54,044,409 | 2,180 | $60,864,870 | Nov 17 | Paramount Pictures | false |
| 8 | Sea of Love | - | - | - | $32,444,398 | 1,439 | $58,571,513 | Sep 15 | Universal Pictures | false |
| 44 | The Abyss | - | - | - | $3,624,733 | 1,538 | $54,222,310 | Aug 11 | Twentieth Century Fox | false |
| 10 | Black Rain | - | - | - | $31,031,787 | 1,760 | $46,212,055 | Sep 22 | Paramount Pictures | false |
| 25 | Always | - | - | - | $10,953,485 | 1,206 | $43,858,790 | Dec 22 | Universal Pictures | false |
| 9 | The Bear | - | - | - | $31,753,898 | 1,056 | $31,753,898 | Oct 27 | TriStar Pictures | false |
| 12 | All Dogs Go to Heaven | - | - | - | $20,284,394 | 1,591 | $27,100,027 | Nov 17 | United Artists | false |
| 63 | Glory | - | - | - | $329,420 | 811 | $26,828,365 | Dec 14 | TriStar Pictures | false |
| 27 | Sex, Lies, and Videotape | - | - | - | $8,394,754 | 534 | $24,741,667 | Aug 4 | Miramax | false |
| 11 | Dad | - | - | - | $22,103,037 | 1,188 | $22,103,037 | Oct 27 | Universal Pictures | false |
| 13 | An Innocent Man | - | - | - | $20,047,604 | 1,561 | $20,047,604 | Oct 6 | Walt Disney Studios Motion Pictures | false |
| 28 | Blaze | - | - | - | $8,318,647 | 970 | $19,131,246 | Dec 15 | Walt Disney Studios Motion Pictures | false |
| 14 | Prancer | - | - | - | $18,587,135 | 1,728 | $18,587,135 | Nov 17 | Orion Pictures | false |
| 15 | The Fabulous Baker Boys | - | - | - | $18,428,904 | 860 | $18,428,904 | Oct 13 | Twentieth Century Fox | false |
| 16 | Crimes and Misdemeanors | - | - | - | $18,254,702 | 525 | $18,254,702 | Oct 13 | Orion Pictures | false |
| 18 | Shocker | - | - | - | $16,554,699 | 1,795 | $16,554,699 | Oct 27 | Universal Pictures | false |
| 19 | Next of Kin | - | - | - | $15,942,628 | 1,358 | $15,942,628 | Oct 20 | Warner Bros. | false |
| 26 | She-Devil | - | - | - | $9,846,622 | 1,452 | $15,351,421 | Dec 8 | Orion Pictures | false |
| 73 | My Left Foot | - | - | - | $65,732 | 510 | $14,743,391 | Nov 10 | Miramax | false |
| 42 | Kickboxer | - | - | - | $3,909,186 | 973 | $14,697,005 | Sep 8 | Cannon Film Distributors | false |
| 29 | The Wizard | - | - | - | $7,686,199 | 1,204 | $14,278,900 | Dec 15 | Universal Pictures | false |
| 30 | Family Business | - | - | - | $7,438,993 | 1,230 | $12,195,695 | Dec 15 | TriStar Pictures | false |
| 23 | Halloween 5: The Revenge of Michael Myers | - | - | - | $11,642,254 | 1,495 | $11,642,254 | Oct 13 | - | false |
| 24 | Gross Anatomy | - | - | - | $11,604,598 | 1,080 | $11,604,598 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 32 | We're No Angels | - | - | - | $6,910,853 | 1,495 | $10,555,348 | Dec 15 | Paramount Pictures | false |
| 67 | Henry V | - | - | - | $207,549 | 134 | $10,161,099 | Nov 8 | The Samuel Goldwyn Company | false |
| 61 | Enemies, A Love Story | - | - | - | $470,485 | 75 | $7,754,571 | Dec 15 | Twentieth Century Fox | false |
| 34 | Johnny Handsome | - | - | - | $6,303,625 | 813 | $7,237,794 | Sep 29 | TriStar Pictures | false |
| 64 | Roger & Me | - | - | - | $285,579 | 265 | $6,706,368 | Dec 22 | Warner Bros. | false |
| 70 | Music Box | - | - | - | $97,835 | 462 | $6,263,883 | Dec 22 | TriStar Pictures | false |
| 36 | Immediate Family | - | - | - | $5,932,613 | 836 | $5,932,613 | Oct 27 | Columbia Pictures | false |
| 38 | Second Sight | - | - | - | $5,368,865 | 815 | $5,368,865 | Nov 3 | Warner Bros. | false |
| 39 | Drugstore Cowboy | - | - | - | $4,729,352 | 87 | $4,729,352 | Oct 6 | Avenue Pictures Productions | false |
| 40 | Staying Together | - | - | - | $4,348,025 | 1,045 | $4,348,025 | Nov 10 | Hemdale | false |
| 41 | The Phantom of the Opera | - | - | - | $3,953,745 | 1,468 | $3,953,745 | Nov 3 | - | false |
| 47 | A Dry White Season | - | - | - | $3,459,921 | 316 | $3,766,879 | Sep 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 43 | Worth Winning | - | - | - | $3,690,328 | 1,260 | $3,690,328 | Oct 27 | Twentieth Century Fox | false |
| 45 | Old Gringo | - | - | - | $3,574,256 | 237 | $3,574,256 | Oct 6 | Columbia Pictures | false |
| 46 | Fat Man and Little Boy | - | - | - | $3,563,162 | 843 | $3,563,162 | Oct 20 | Paramount Pictures | false |
| 52 | In Country | - | - | - | $1,610,635 | 606 | $3,531,971 | Sep 15 | Warner Bros. | false |
| 69 | Camille Claudel | - | - | - | $99,273 | 34 | $3,331,297 | Dec 21 | Orion Classics | false |
| 51 | Erik the Viking | - | - | - | $1,681,445 | 269 | $1,932,642 | Sep 22 | Orion Pictures | false |
| 48 | Communion | - | - | - | $1,919,653 | 240 | $1,919,653 | Nov 10 | New Line Cinema | false |
| 49 | Breaking In | - | - | - | $1,877,618 | 400 | $1,877,618 | Oct 13 | The Samuel Goldwyn Company | false |
| 50 | Best of the Best | - | - | - | $1,700,000 | 600 | $1,700,000 | Nov 10 | Taurus Entertainment Company | false |
| 54 | Romero | - | - | - | $1,297,668 | 51 | $1,316,495 | Aug 25 | Four Square | false |
| 56 | Valmont | - | - | - | $1,132,112 | 7 | $1,132,112 | Nov 17 | Orion Pictures | false |
| 57 | The Music Teacher | - | - | - | $1,057,934 | 19 | $1,086,894 | Jul 7 | Orion Classics | false |
| 58 | Crack House | - | - | - | $862,551 | 67 | $862,551 | Nov 10 | Cannon Film Distributors | false |
| 76 | For All Mankind | - | - | - | $54,175 | 9 | $770,132 | Nov 1 | Apollo Associates | false |
| 60 | Thelonious Monk: Straight, No Chaser | - | - | - | $514,638 | 11 | $518,918 | Oct 1 | Warner Bros. | false |
| 81 | Akira | - | - | - | $11,690 | 2 | $439,162 | Dec 25 | - | false |
| 78 | Triumph of the Spirit | - | - | - | $46,569 | 40 | $408,839 | Dec 8 | Triumph Releasing Corporation | false |
| 62 | The Toxic Avenger Part III: The Last Temptation of Toxie | - | - | - | $363,561 | 40 | $363,561 | Nov 10 | Troma | false |
| 65 | Kill Me Again | - | - | - | $283,694 | 221 | $283,694 | Oct 27 | - | false |
| 68 | Heavy Petting | - | - | - | $156,606 | 11 | $272,371 | Sep 22 | Skouras Pictures | false |
| 66 | Weapons of the Spirit | - | - | - | $209,756 | 4 | $232,981 | Sep 1 | First Run | false |
| 71 | After Midnight | - | - | - | $76,325 | 224 | $76,325 | Nov 3 | Metro-Goldwyn-Mayer (MGM) | false |
| 72 | When the Whales Came | - | - | - | $73,131 | 10 | $73,131 | Oct 20 | Twentieth Century Fox | false |
| 74 | Survival Quest | - | - | - | $62,683 | 168 | $62,683 | Nov 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 75 | Ten Little Indians | - | - | - | $59,405 | 79 | $59,405 | Nov 10 | Cannon Film Distributors | false |
| 77 | Fear Anxiety Depression | - | - | - | $47,148 | 1 | $47,148 | Dec 8 | The Samuel Goldwyn Company | false |
| 79 | Bloodhounds of Broadway | - | - | - | $43,671 | 5 | $43,671 | Nov 3 | Columbia Pictures | false |
| 80 | Animal Behavior | - | - | - | $41,526 | 24 | $41,526 | Oct 27 | Miramax | false |
| 82 | High Stakes | - | - | - | $4,780 | 1 | $4,780 | Nov 17 | Trimark Pictures | false |
