| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Doctor Strange in the Multiverse of Madness | - | - | - | $1,554,422 | 189 | $1,882,765 | 82.6% | May 6, 2022 | Ster-Kinekor Pictures |
| 2 | The Lost City | - | - | - | $377,428 | 98 | $1,068,102 | 35.3% | Apr 22, 2022 | United International Pictures |
| 3 | Sonic the Hedgehog 2 | - | - | - | $241,978 | 89 | $1,489,059 | 16.3% | Apr 1, 2022 | Paramount Pictures International |
| 4 | Mr. Bones 3: Son of Bones | - | - | - | $198,750 | 83 | $712,890 | 27.9% | Apr 15, 2022 | Ster-Kinekor Pictures |
| 5 | The Bad Guys | - | - | - | $92,956 | 103 | $425,317 | 21.9% | Apr 8, 2022 | United International Pictures |
| 6 | Memory | - | - | - | $74,838 | 71 | $116,841 | 64.1% | Apr 29, 2022 | Universal Pictures |
| 7 | Downton Abbey: A New Era | - | - | - | $70,359 | 32 | $125,751 | 56% | Apr 29, 2022 | United International Pictures |
| 8 | Fantastic Beasts: The Secrets of Dumbledore | - | - | - | $55,223 | 116 | $510,267 | 10.8% | Apr 15, 2022 | Universal Pictures |
| 9 | My Sweet Monster | - | - | - | $26,416 | 51 | $41,089 | 64.3% | May 20, 2022 | Ster-Kinekor Pictures |
| 10 | Indemnity | - | - | - | $25,724 | 70 | $27,703 | 92.9% | May 13, 2022 | Ster-Kinekor Pictures |
| 11 | The Batman | - | - | - | $25,638 | 115 | $1,382,311 | 1.9% | Apr 3, 2022 | Universal Pictures |
| 12 | Everything Everywhere All at Once | - | - | - | $21,839 | 10 | $84,058 | 26% | May 13, 2022 | Times Media Films |
| 13 | Encanto | - | - | - | $21,625 | 100 | $1,006,951 | 2.1% | Nov 26, 2021 | Ster-Kinekor Pictures |
| 14 | Chickenhare and the Hamster of Darkness | - | - | - | $20,292 | 91 | $66,138 | 30.7% | Apr 22, 2022 | Ster-Kinekor Pictures |
| 15 | Firestarter | - | - | - | $19,235 | 37 | $20,372 | 94.4% | May 13, 2022 | United International Pictures |
| 16 | Turning Red | - | - | - | $17,381 | 101 | $532,787 | 3.3% | Mar 11, 2022 | Ster-Kinekor Pictures |
| 17 | Operation Mincemeat | - | - | - | $15,486 | 15 | $21,162 | 73.2% | May 6, 2022 | Times Media Films |
| 18 | Marmaduke | - | - | - | $15,427 | 51 | $68,255 | 22.6% | May 27, 2022 | Universal Pictures |
| 19 | Uncharted | - | - | - | $14,910 | 130 | $1,389,570 | 1.1% | Feb 18, 2022 | Ster-Kinekor Pictures |
| 20 | The Unbearable Weight of Massive Talent | - | - | - | $13,079 | 42 | $29,571 | 44.2% | Apr 22, 2022 | Universal Pictures |
| 21 | Death on the Nile | - | - | - | $7,142 | 68 | $206,476 | 3.5% | Nov 2, 2022 | Ster-Kinekor Pictures |
| 22 | King Richard | - | - | - | $3,193 | 50 | $67,574 | 4.7% | Nov 19, 2021 | Universal Pictures |
| 23 | Belfast | - | - | - | $2,619 | 16 | $44,182 | 5.9% | Mar 4, 2022 | United International Pictures |
| 24 | Thando | - | - | - | $2,442 | 31 | $20,511 | 11.9% | Apr 8, 2022 | Indigenous Film Distribution |
| 25 | Morbius | - | - | - | $1,677 | 122 | $359,066 | 0.5% | Apr 1, 2022 | Ster-Kinekor Pictures |
| 26 | Licorice Pizza | - | - | - | $1,318 | 11 | $20,091 | 6.6% | Jan 28, 2022 | Universal Pictures |
| 27 | The Last Bus | - | - | - | $1,186 | 14 | $12,493 | 9.5% | Apr 8, 2022 | Indigenous Film Distribution |
| 28 | The Electrical Life of Louis Wain | - | - | - | $595 | 1 | $2,448 | 24.3% | Apr 15, 2022 | Universal Pictures |
| 29 | House of Gucci | - | - | - | $312 | 67 | $225,126 | 0.1% | Dec 3, 2021 | Times Media Films |
