| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | The Bad Guys | - | - | - | $5,839,940 | 4,042 | $97,459,240 | 6% | Apr 22, 2022 | Universal Pictures |
| 2 | Sonic the Hedgehog 2 | - | - | - | $4,373,379 | 4,258 | $190,872,904 | 2.3% | Apr 8, 2022 | Paramount Pictures |
| 3 | Fantastic Beasts: The Secrets of Dumbledore | - | - | - | $3,074,765 | 4,245 | $95,850,844 | 3.2% | Apr 15, 2022 | Warner Bros. |
| 4 | The Northman | - | - | - | $2,448,260 | 3,284 | $34,233,110 | 7.2% | Apr 22, 2022 | Focus Features |
| 5 | Everything Everywhere All at Once | - | - | - | $2,441,326 | 2,220 | $77,191,785 | 3.2% | Mar 25, 2022 | A24 |
| 6 | The Unbearable Weight of Massive Talent | - | - | - | $1,420,744 | 3,036 | $20,300,157 | 7% | Apr 22, 2022 | Lionsgate Films |
| 7 | The Lost City | - | - | - | $1,270,529 | 4,283 | $105,344,029 | 1.2% | Mar 25, 2022 | Paramount Pictures |
| 8 | Memory | - | - | - | $1,062,464 | 2,555 | $7,329,043 | 14.5% | Apr 29, 2022 | Open Road Films (II) |
| 9 | Father Stu | - | - | - | $859,068 | 2,705 | $20,884,796 | 4.1% | Apr 13, 2022 | Sony Pictures Releasing |
| 10 | Morbius | - | - | - | $576,547 | 4,268 | $73,865,530 | 0.8% | Apr 1, 2022 | Columbia Pictures |
| 11 | Ambulance | - | - | - | $430,085 | 3,412 | $22,781,115 | 1.9% | Apr 8, 2022 | Universal Pictures |
| 12 | The Batman | - | - | - | $277,373 | 4,417 | $369,345,583 | <0.1% | Mar 4, 2022 | Warner Bros. |
| 13 | The Duke | - | - | - | $176,867 | 353 | $1,526,970 | 11.6% | Apr 22, 2022 | Sony Pictures Classics |
| 14 | ¿Y cómo es él? | - | - | - | $131,569 | 325 | $1,500,636 | 8.8% | Apr 22, 2022 | Lionsgate Films |
| 15 | Uncharted | - | - | - | $103,368 | 4,275 | $148,648,820 | <0.1% | Feb 18, 2022 | Sony Pictures Releasing |
| 16 | Eiffel | - | - | - | $80,504 | 308 | $444,814 | 18.1% | Apr 29, 2022 | Blue Fox Entertainment |
| 17 | Jujutsu Kaisen 0 | - | - | - | $50,761 | 2,418 | $34,542,754 | 0.1% | Mar 18, 2022 | Crunchyroll |
| 18 | Spider-Man: No Way Home | - | - | - | $50,685 | 4,336 | $804,793,477 | <0.1% | Dec 17, 2021 | Sony Pictures Releasing |
| 19 | Hatching | - | - | - | $45,067 | 190 | $182,925 | 24.6% | Apr 29, 2022 | IFC Films |
| 20 | Anaïs in Love | - | - | - | $30,889 | 55 | $42,941 | 71.9% | Apr 29, 2022 | Magnolia Pictures |
| 21 | Petite Maman | - | - | - | $28,096 | 224 | $829,065 | 3.4% | Apr 22, 2022 | Neon |
| 22 | Inland Empire 2022 Re-release | - | - | - | $26,919 | 14 | $253,523 | 10.6% | Apr 8, 2022 | Janus Films |
| 23 | Firebird | - | - | - | $24,871 | 89 | $144,118 | 17.3% | Apr 29, 2022 | Roadside Attractions |
| 24 | Hit the Road | - | - | - | $21,488 | 432 | $151,018 | 14.2% | Apr 22, 2022 | Kino Lorber |
| 25 | The Rose Maker | - | - | - | $18,220 | 26 | $119,160 | 15.3% | Apr 1, 2022 | Music Box Films |
| 26 | Sing 2 | - | - | - | $17,670 | 3,892 | $162,790,990 | <0.1% | Dec 22, 2021 | Universal Pictures |
| 27 | The Automat | - | - | - | $16,423 | 20 | $257,371 | 6.4% | Feb 18, 2022 | Slice of Pie |
| 28 | Green Ghost and the Masters of the Stone | - | - | - | $13,163 | 135 | $113,685 | 11.6% | Apr 29, 2022 | Gravitas Ventures |
| 29 | Pompo: The Cinéphile | - | - | - | $12,974 | 736 | $164,528 | 7.9% | Apr 27, 2022 | GKIDS |
| 30 | Dog | - | - | - | $10,927 | 3,827 | $61,778,069 | <0.1% | Feb 18, 2022 | United Artists Releasing |
| 31 | The Wobblies 2022 Re-release | - | - | - | $10,240 | 13 | $12,232 | 83.7% | Apr 29, 2022 | Kino Lorber |
| 32 | Mothering Sunday | - | - | - | $8,532 | 293 | $275,352 | 3.1% | Mar 25, 2022 | Sony Pictures Classics |
| 33 | Waterman | - | - | - | $8,418 | 44 | $316,848 | 2.7% | Apr 1, 2022 | Purdie Distribution |
| 34 | Take Me to the River: New Orleans | - | - | - | $8,269 | 33 | $43,563 | 19% | Apr 22, 2022 | N/A |
| 35 | X | - | - | - | $7,885 | 2,920 | $11,765,309 | <0.1% | Mar 18, 2022 | A24 |
| 36 | The Sound of Violet | - | - | - | $6,364 | 29 | $32,333 | 19.7% | Apr 29, 2022 | Atlas Distribution Company |
| 37 | The Tale of King Crab | - | - | - | $6,110 | 9 | $26,919 | 22.7% | Apr 15, 2022 | Oscilloscope |
| 38 | Charlotte | - | - | - | $5,789 | 20 | $18,520 | 31.3% | Apr 22, 2022 | Good Deed Entertainment |
| 39 | Mississippi Masala 2022 Re-release | - | - | - | $3,595 | 7 | $23,729 | 15.2% | Apr 15, 2022 | Janus Films |
| 40 | Parallel Mothers | - | - | - | $2,085 | 684 | $2,297,501 | <0.1% | Dec 24, 2021 | Sony Pictures Classics |
| 41 | Paris, 13th District | - | - | - | $2,027 | 67 | $73,118 | 2.8% | Apr 15, 2022 | IFC Films |
| 42 | Aline | - | - | - | $1,409 | 72 | $667,815 | 0.2% | Nov 26, 2021 | Roadside Attractions |
| 43 | Bronco Bullfrog 2022 Re-release | - | - | - | $1,269 | 2 | $13,171 | 9.6% | Mar 25, 2022 | Seventy-Seven |
| 44 | Love in Kilnerry | - | - | - | $1,178 | 11 | $213,099 | 0.6% | Apr 8, 2022 | Archway Pictures |
| 45 | The Velvet Queen | - | - | - | $788 | 51 | $151,006 | 0.5% | Dec 22, 2021 | Oscilloscope |
| 46 | Compartment Number 6 | - | - | - | $754 | 140 | $205,843 | 0.4% | Jan 26, 2022 | Sony Pictures Classics |
| 47 | Cow | - | - | - | $432 | 32 | $22,504 | 1.9% | Apr 8, 2022 | IFC Films |
| 48 | Strawberry Mansion | - | - | - | $237 | 28 | $97,526 | 0.2% | Feb 18, 2022 | Music Box Films |
| 49 | I've Heard the Mermaids Singing 2022 Re-release | - | - | - | $217 | 4 | $6,903 | 3.1% | Mar 11, 2022 | Kino Lorber |
| 50 | Stunt Rock 2022 Re-release | - | - | - | $208 | 15 | $9,530 | 2.2% | Mar 25, 2022 | Kino Lorber |
| 51 | Ahed's Knee | - | - | - | $28 | 18 | $52,702 | <0.1% | Mar 18, 2022 | Kino Lorber |
