| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Spider-Man: No Way Home | - | - | - | $195,905,991 | 4,336 | $804,793,477 | 24.3% | Dec 17, 2021 | Sony Pictures Releasing |
| 2 | Encanto | - | - | - | $36,150,777 | 3,980 | $96,093,622 | 37.6% | Nov 24, 2021 | Walt Disney Studios Motion Pictures |
| 3 | Ghostbusters: Afterlife | - | - | - | $26,257,732 | 4,315 | $129,360,575 | 20.3% | Nov 19, 2021 | Sony Pictures Releasing |
| 4 | House of Gucci | - | - | - | $19,740,697 | 3,477 | $53,809,574 | 36.7% | Nov 24, 2021 | United Artists Releasing |
| 5 | West Side Story | - | - | - | $17,058,845 | 2,820 | $38,530,322 | 44.3% | Dec 10, 2021 | 20th Century Studios |
| 6 | Christmas with the Chosen: The Messengers | - | - | - | $13,728,000 | 1,700 | $13,728,000 | 100% | Dec 1, 2021 | Fathom Events |
| 7 | Eternals | - | - | - | $11,481,568 | 4,090 | $164,870,234 | 7% | Nov 5, 2021 | Walt Disney Studios Motion Pictures |
| 8 | Resident Evil: Welcome to Raccoon City | - | - | - | $6,883,206 | 2,803 | $17,000,612 | 40.5% | Nov 24, 2021 | Screen Gems |
| 9 | Clifford the Big Red Dog | - | - | - | $4,938,519 | 3,700 | $48,947,356 | 10.1% | Nov 10, 2021 | Paramount Pictures |
| 10 | Dune: Part One | - | - | - | $4,310,508 | 4,125 | $108,327,830 | 4% | Oct 22, 2021 | Warner Bros. |
| 11 | King Richard | - | - | - | $2,823,226 | 3,302 | $15,129,285 | 18.7% | Nov 19, 2021 | Warner Bros. |
| 12 | Venom: Let There Be Carnage | - | - | - | $2,630,394 | 4,225 | $213,550,366 | 1.2% | Oct 1, 2021 | Sony Pictures Releasing |
| 13 | No Time to Die | - | - | - | $2,419,233 | 4,407 | $160,891,007 | 1.5% | Oct 8, 2021 | Metro-Goldwyn-Mayer (MGM) |
| 14 | Nightmare Alley | - | - | - | $2,136,894 | 2,145 | $11,338,107 | 18.8% | Dec 17, 2021 | Searchlight Pictures |
| 15 | Belfast | - | - | - | $1,542,935 | 1,255 | $9,250,870 | 16.7% | Nov 12, 2021 | Focus Features |
| 16 | The French Dispatch | - | - | - | $1,155,059 | 1,225 | $16,124,375 | 7.2% | Oct 22, 2021 | Searchlight Pictures |
| 17 | C'mon C'mon | - | - | - | $1,081,907 | 569 | $1,863,674 | 58.1% | Nov 19, 2021 | A24 |
| 18 | Sword Art Online: Progressive - Aria of a Starless Night | - | - | - | $1,050,000 | 840 | $1,050,000 | 100% | Dec 3, 2021 | FUNimation Entertainment |
| 19 | True to the Game 3 | - | - | - | $1,038,255 | 440 | $1,038,255 | 100% | Dec 3, 2021 | Faith Media Distribution |
| 20 | Licorice Pizza | - | - | - | $818,037 | 1,977 | $17,318,007 | 4.7% | Nov 26, 2021 | United Artists Releasing |
| 21 | National Champions | - | - | - | $442,530 | 1,197 | $475,488 | 93.1% | Dec 10, 2021 | STX Entertainment |
| 22 | Spencer | - | - | - | $381,365 | 1,265 | $7,086,632 | 5.4% | Nov 5, 2021 | Neon |
| 23 | Aline | - | - | - | $336,407 | 72 | $667,815 | 50.4% | Nov 26, 2021 | Roadside Attractions |
| 24 | Benedetta | - | - | - | $314,318 | 201 | $354,481 | 88.7% | Dec 3, 2021 | IFC Films |
| 25 | L'Arracheuse de temps | - | - | - | $266,754 | 72 | $750,623 | 35.5% | Nov 19, 2021 | Entertainment One |
| 26 | Ron's Gone Wrong | - | - | - | $226,641 | 3,560 | $23,009,270 | 1% | Oct 22, 2021 | 20th Century Studios |
| 27 | Red Rocket | - | - | - | $176,352 | 385 | $1,023,086 | 17.2% | Dec 10, 2021 | A24 |
| 28 | The Lady of Heaven | - | - | - | $173,765 | 59 | $291,597 | 59.6% | Dec 10, 2021 | Universal Pictures International (UPI) |
| 29 | Drive My Car | - | - | - | $173,337 | 213 | $2,352,240 | 7.4% | Nov 24, 2021 | Janus Films |
| 30 | For the Love of Money | - | - | - | $149,276 | 519 | $480,774 | 31% | Nov 24, 2021 | Freestyle Releasing |
| 31 | Wolf | - | - | - | $147,595 | 308 | $147,595 | 100% | Dec 3, 2021 | Focus Features |
| 32 | Tadap | - | - | - | $130,934 | 63 | $130,934 | 100% | Dec 3, 2021 | FIP |
| 33 | Julia | - | - | - | $113,524 | 288 | $399,811 | 28.4% | Nov 12, 2021 | Sony Pictures Classics |
| 34 | Antlers | - | - | - | $100,882 | 2,800 | $10,619,670 | 0.9% | Oct 29, 2021 | Searchlight Pictures |
| 35 | Anita | - | - | - | $100,410 | 15 | $556,632 | 18% | Nov 12, 2021 | CMC Pictures |
| 36 | The Battle at Lake Changjin | - | - | - | $79,886 | 20 | $342,411 | 23.3% | Nov 19, 2021 | CMC Pictures |
| 37 | My Hero Academia: World Heroes' Mission | - | - | - | $67,426 | 1,585 | $12,271,658 | 0.5% | Oct 29, 2021 | FUNimation Entertainment |
| 38 | The Addams Family 2 | - | - | - | $51,904 | 4,207 | $56,489,153 | <0.1% | Oct 1, 2021 | United Artists Releasing |
| 39 | Flee | - | - | - | $46,451 | 220 | $339,754 | 13.7% | Dec 3, 2021 | Neon |
| 40 | Try Harder! | - | - | - | $32,432 | 5 | $32,432 | 100% | Dec 3, 2021 | Greenwich Entertainment |
| 41 | Halloween Kills | - | - | - | $27,785 | 3,727 | $92,002,155 | <0.1% | Oct 15, 2021 | Universal Pictures |
| 42 | Bad Luck Banging or Loony Porn | - | - | - | $25,875 | 16 | $72,342 | 35.8% | Nov 19, 2021 | Magnolia Pictures |
| 43 | India Sweets and Spices | - | - | - | $15,649 | 343 | $288,714 | 5.4% | Nov 19, 2021 | Bleecker Street Media |
| 44 | The Scary of Sixty-First | - | - | - | $13,999 | 9 | $45,005 | 31.1% | Dec 3, 2021 | Utopia |
| 45 | France | - | - | - | $11,937 | 12 | $49,347 | 24.2% | Dec 10, 2021 | Kino Lorber |
| 46 | Torn | - | - | - | $11,528 | 22 | $52,816 | 21.8% | Dec 3, 2021 | Dada Films |
| 47 | Kurt Vonnegut: Unstuck in Time | - | - | - | $9,997 | 69 | $60,389 | 16.6% | Nov 19, 2021 | IFC Films |
| 48 | The Novice | - | - | - | $9,364 | 36 | $24,322 | 38.5% | Dec 17, 2021 | IFC Films |
| 49 | Writing with Fire | - | - | - | $8,284 | 9 | $28,262 | 29.3% | Nov 26, 2021 | Music Box Films |
| 50 | The Rescue | - | - | - | $8,138 | 561 | $1,060,556 | 0.8% | Oct 8, 2021 | Greenwich Entertainment |
| 51 | A Revision | - | - | - | $7,521 | 51 | $161,074 | 4.7% | Nov 5, 2021 | Entertainment One |
| 52 | Last Night in Soho | - | - | - | $5,975 | 3,016 | $10,127,625 | <0.1% | Oct 29, 2021 | Focus Features |
| 53 | Harper | - | - | - | $4,824 | 5 | $20,268 | 23.8% | Dec 15, 2021 | Indican Pictures |
| 54 | Nights of Cabiria 2021 Re-release | - | - | - | $4,749 | 4 | $14,485 | 32.8% | Dec 17, 2021 | Rialto Pictures |
| 55 | The Last Duel | - | - | - | $3,604 | 3,065 | $10,853,945 | <0.1% | Oct 15, 2021 | 20th Century Studios |
| 56 | Shang-Chi and the Legend of the Ten Rings | - | - | - | $2,943 | 4,300 | $224,543,292 | <0.1% | Sep 3, 2021 | Walt Disney Studios Motion Pictures |
| 57 | I Was a Simple Man | - | - | - | $2,213 | 6 | $12,669 | 17.5% | Nov 19, 2021 | Strand Releasing |
| 58 | What Do We See When We Look at the Sky? | - | - | - | $2,028 | 4 | $21,443 | 9.5% | Nov 12, 2021 | MUBI |
| 59 | Agnes | - | - | - | $1,902 | 6 | $2,113 | 90% | Dec 10, 2021 | Magnolia Pictures |
| 60 | Free Guy | - | - | - | $1,577 | 4,165 | $121,626,598 | <0.1% | Aug 13, 2021 | 20th Century Studios |
| 61 | The Feast | - | - | - | $1,402 | 22 | $8,316 | 16.9% | Nov 19, 2021 | IFC Films |
| 62 | Luzzu | - | - | - | $710 | 5 | $39,948 | 1.8% | Oct 15, 2021 | Kino Lorber |
| 63 | Breathless 2021 Re-release | - | - | - | $532 | 7 | $51,142 | 1% | Sep 24, 2021 | Rialto Pictures |
| 64 | The Incredibly True Adventure of Two Girls in Love 2021 Re-release | - | - | - | $490 | 1 | $3,519 | 13.9% | Nov 24, 2021 | Strand Releasing |
| 65 | Golden Voices | - | - | - | $347 | 14 | $32,250 | 1.1% | Oct 8, 2021 | Music Box Films |
| 66 | Shiva Baby | - | - | - | $296 | 27 | $159,294 | 0.2% | Apr 2, 2021 | Utopia |
| 67 | Azor | - | - | - | $180 | 52 | $53,932 | 0.3% | Sep 10, 2021 | MUBI |
| 68 | Cicada | - | - | - | $156 | 4 | $13,370 | 1.2% | Oct 29, 2021 | Strand Releasing |
