| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Dune: Part One | - | - | - | $7,041,444 | 4,125 | $108,327,830 | 6.5% | Oct 22, 2021 | Warner Bros. |
| 2 | No Time to Die | - | - | - | $3,707,479 | 4,407 | $160,891,007 | 2.3% | Oct 8, 2021 | Metro-Goldwyn-Mayer (MGM) |
| 3 | Venom: Let There Be Carnage | - | - | - | $2,100,521 | 4,225 | $213,550,366 | 1% | Oct 1, 2021 | Sony Pictures Releasing |
| 4 | My Hero Academia: World Heroes' Mission | - | - | - | $1,957,598 | 1,585 | $12,271,658 | 16% | Oct 29, 2021 | FUNimation Entertainment |
| 5 | Last Night in Soho | - | - | - | $1,660,175 | 3,016 | $10,127,625 | 16.4% | Oct 29, 2021 | Focus Features |
| 6 | Halloween Kills | - | - | - | $1,488,110 | 3,727 | $92,002,155 | 1.6% | Oct 15, 2021 | Universal Pictures |
| 7 | Ron's Gone Wrong | - | - | - | $1,421,229 | 3,560 | $23,009,270 | 6.2% | Oct 22, 2021 | 20th Century Studios |
| 8 | The French Dispatch | - | - | - | $1,389,710 | 1,225 | $16,124,375 | 8.6% | Oct 22, 2021 | Searchlight Pictures |
| 9 | Antlers | - | - | - | $1,334,562 | 2,800 | $10,619,670 | 12.6% | Oct 29, 2021 | Searchlight Pictures |
| 10 | The Addams Family 2 | - | - | - | $840,698 | 4,207 | $56,489,153 | 1.5% | Oct 1, 2021 | United Artists Releasing |
| 11 | Shang-Chi and the Legend of the Ten Rings | - | - | - | $473,863 | 4,300 | $224,543,292 | 0.2% | Sep 3, 2021 | Walt Disney Studios Motion Pictures |
| 12 | The Last Duel | - | - | - | $305,945 | 3,065 | $10,853,945 | 2.8% | Oct 15, 2021 | 20th Century Studios |
| 13 | Ghostbusters 2021 Re-release | - | - | - | $87,401 | 774 | $391,718 | 22.3% | Oct 29, 2021 | Sony Pictures Classics |
| 14 | A Mouthful of Air | - | - | - | $82,132 | 816 | $269,435 | 30.5% | Oct 29, 2021 | Stage 6 Films |
| 15 | The Rescue | - | - | - | $43,228 | 561 | $1,060,556 | 4.1% | Oct 8, 2021 | Greenwich Entertainment |
| 16 | Free Guy | - | - | - | $33,152 | 4,165 | $121,626,598 | <0.1% | Aug 13, 2021 | 20th Century Studios |
| 17 | Becoming Cousteau | - | - | - | $21,802 | 319 | $231,687 | 9.4% | Oct 22, 2021 | Picturehouse |
| 18 | Dear Evan Hansen | - | - | - | $18,820 | 3,364 | $15,002,646 | 0.1% | Sep 24, 2021 | Universal Pictures |
| 19 | The Souvenir: Part II | - | - | - | $18,540 | 42 | $98,929 | 18.7% | Oct 29, 2021 | A24 |
| 20 | Candyman | - | - | - | $15,395 | 3,569 | $61,186,570 | <0.1% | Aug 27, 2021 | Universal Pictures |
| 21 | Jungle Cruise | - | - | - | $13,999 | 4,310 | $116,987,516 | <0.1% | Jul 30, 2021 | Walt Disney Studios Motion Pictures |
| 22 | Mass | - | - | - | $10,322 | 59 | $145,174 | 7.1% | Oct 8, 2021 | Bleecker Street Media |
| 23 | Cry Macho | - | - | - | $9,533 | 4,022 | $10,310,734 | <0.1% | Sep 17, 2021 | Warner Bros. |
| 24 | The Eyes of Tammy Faye | - | - | - | $5,664 | 1,352 | $2,404,127 | 0.2% | Sep 17, 2021 | Searchlight Pictures |
| 25 | Bergman Island | - | - | - | $4,141 | 115 | $145,191 | 2.9% | Oct 15, 2021 | IFC Films |
| 26 | The Many Saints of Newark | - | - | - | $3,711 | 3,181 | $8,237,403 | <0.1% | Oct 1, 2021 | Warner Bros. |
| 27 | Learning to Live Together: The Return of Mad Dogs & Englishmen | - | - | - | $3,564 | 4 | $18,293 | 19.5% | Oct 22, 2021 | Abramorama |
| 28 | Cicada | - | - | - | $2,708 | 4 | $13,370 | 20.3% | Oct 29, 2021 | Strand Releasing |
| 29 | In Balanchine's Classroom | - | - | - | $2,384 | 9 | $76,650 | 3.1% | Sep 17, 2021 | Zeitgeist Films |
| 30 | Only the Animals | - | - | - | $2,315 | 6 | $9,138 | 25.3% | Oct 29, 2021 | Cohen Media Group |
| 31 | Minyan | - | - | - | $2,212 | 3 | $11,451 | 19.3% | Oct 22, 2021 | Strand Releasing |
| 32 | Golden Voices | - | - | - | $2,052 | 14 | $32,250 | 6.4% | Oct 8, 2021 | Music Box Films |
| 33 | The Alpinist | - | - | - | $1,519 | 245 | $844,743 | 0.2% | Sep 10, 2021 | Roadside Attractions |
| 34 | The Laws of the Universe: The Age of Elohim | - | - | - | $1,475 | 7 | $15,750 | 9.4% | Oct 22, 2021 | Freestyle Releasing |
| 35 | I'm Your Man | - | - | - | $1,212 | 122 | $275,155 | 0.4% | Sep 24, 2021 | Bleecker Street Media |
| 36 | Ascension | - | - | - | $1,028 | 6 | $17,200 | 6% | Oct 8, 2021 | MTV Documentary Films |
| 37 | Wife of a Spy | - | - | - | $928 | 21 | $69,464 | 1.3% | Sep 17, 2021 | Kino Lorber |
| 38 | Luzzu | - | - | - | $772 | 5 | $39,948 | 1.9% | Oct 15, 2021 | Kino Lorber |
| 39 | Labyrinth of Cinema | - | - | - | $728 | 5 | $4,501 | 16.2% | Oct 20, 2021 | MTV Documentary Films |
| 40 | Falling for Figaro | - | - | - | $480 | 44 | $35,910 | 1.3% | Oct 1, 2021 | IFC Films |
| 41 | The Lost Leonardo | - | - | - | $308 | 217 | $445,740 | <0.1% | Aug 13, 2021 | Sony Pictures Classics |
| 42 | Tango Shalom | - | - | - | $302 | 29 | $102,651 | 0.3% | Sep 3, 2021 | Vision Films |
| 43 | Nine Days | - | - | - | $252 | 443 | $694,849 | <0.1% | Jul 30, 2021 | Sony Pictures Classics |
| 44 | Little Girl | - | - | - | $152 | 7 | $10,776 | 1.4% | Sep 17, 2021 | Music Box Films |
| 45 | Ema | - | - | - | $28 | 27 | $53,437 | <0.1% | Aug 13, 2021 | Music Box Films |
| 46 | Shiva Baby | - | - | - | $28 | 27 | $159,294 | <0.1% | Apr 2, 2021 | Utopia |
| 47 | Hard Luck Love Song | - | - | - | $24 | 172 | $69,746 | <0.1% | Oct 15, 2021 | Roadside Attractions |
