| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | The Conjuring: The Devil Made Me Do It | - | - | - | $1,612,842 | 397 | $2,480,536 | 65% | Jun 3, 2021 | Warner Bros. |
| 2 | Cruella | - | - | - | $1,339,759 | 569 | $2,878,387 | 46.5% | May 26, 2021 | Walt Disney Studios Motion Pictures |
| 3 | The Father | - | - | - | $637,204 | 338 | $1,447,821 | 44% | May 27, 2021 | BIM Distribuzione |
| 4 | The Bad Poet | - | - | - | $245,029 | 322 | $890,592 | 27.5% | May 20, 2021 | 01 Distribution |
| 5 | Another Round | - | - | - | $199,436 | 242 | $815,062 | 24.5% | May 20, 2021 | Medusa Distribuzione |
| 6 | 100% Wolf | - | - | - | $183,069 | 193 | $443,476 | 41.3% | May 20, 2021 | BIM Distribuzione |
| 7 | Run | - | - | - | $177,909 | 240 | $300,603 | 59.2% | Jun 10, 2021 | STX International |
| 8 | Comedians | - | - | - | $111,922 | 321 | $180,721 | 61.9% | Jun 10, 2021 | 01 Distribution |
| 9 | Freaky | - | - | - | $66,367 | 173 | $121,454 | 54.6% | May 27, 2021 | Universal Pictures International (UPI) |
| 10 | Lassie Come Home | - | - | - | $56,497 | 263 | $56,497 | 100% | Jun 10, 2021 | Lucky Red |
| 11 | Sirley | - | - | - | $56,350 | 84 | $71,523 | 78.8% | Jun 3, 2021 | BIM Distribuzione |
| 12 | Summer of 85 | - | - | - | $55,840 | 56 | $74,427 | 75% | Jun 3, 2021 | - |
| 13 | Nomadland | - | - | - | $55,594 | 195 | $2,356,666 | 2.4% | Apr 29, 2021 | Walt Disney Pictures |
| 14 | The Unholy | - | - | - | $51,670 | 183 | $313,670 | 16.5% | May 20, 2021 | Sony Pictures Releasing |
| 15 | Rifkin's Festival | - | - | - | $48,136 | 205 | $740,455 | 6.5% | May 6, 2021 | - |
| 16 | The Shift 2021 Re-release | - | - | - | $48,072 | 144 | $48,072 | 100% | Jun 3, 2021 | BIM Distribuzione |
| 17 | Oldboy 2021 Re-release | - | - | - | $45,295 | 103 | $82,021 | 55.2% | Jun 9, 2021 | Lucky Red |
| 18 | Perfumes | - | - | - | $35,048 | 52 | $130,344 | 26.9% | Jun 10, 2021 | Satine Film |
| 19 | Bon Jovi From Encore Nights | - | - | - | $27,172 | 158 | $27,172 | 100% | Jun 10, 2021 | Nexo Digital |
| 20 | Tutti per Uma | - | - | - | $26,507 | 202 | $39,424 | 67.2% | Jun 2, 2021 | - |
| 21 | Chungking Express 2021 Re-release | - | - | - | $15,701 | 15 | $47,219 | 33.3% | May 20, 2021 | Tucker Film |
| 22 | The Cordillera of Dreams 2021 Re-release | - | - | - | $9,321 | 19 | $19,681 | 47.4% | Jun 10, 2021 | I Wonder Pictures |
| 23 | About Endlessness | - | - | - | $6,021 | 15 | $9,743 | 61.8% | May 27, 2021 | Wanted |
| 24 | Fortuna | - | - | - | $5,963 | 32 | $14,950 | 39.9% | May 27, 2021 | I Wonder Pictures |
| 25 | Happy Together 2021 Re-release | - | - | - | $4,950 | 9 | $13,902 | 35.6% | May 20, 2021 | Tucker Film |
| 26 | Diary of Love | - | - | - | $4,466 | 22 | $13,161 | 33.9% | May 27, 2021 | Europictures |
| 27 | In the Mood for Love 2021 Re-release | - | - | - | $4,307 | 29 | $188,856 | 2.3% | Apr 28, 2021 | Tucker Film |
| 28 | The Human Voice | - | - | - | $4,079 | 83 | $49,913 | 8.2% | May 13, 2021 | Warner Bros. |
| 29 | Gloria Mundi | - | - | - | $3,940 | 21 | $34,296 | 11.5% | May 13, 2021 | Parthenos |
| 30 | Minari | - | - | - | $3,879 | 74 | $308,013 | 1.3% | Apr 22, 2021 | - |
| 31 | Adam | - | - | - | $3,680 | 9 | $3,680 | 100% | Jun 3, 2021 | Movies Inspired |
| 32 | The Conjuring 2 2021 Re-release | - | - | - | $3,297 | 4 | $166,657 | 2% | - | Warner Bros. |
| 33 | Adventures Italian Style | - | - | - | $3,276 | 99 | $78,410 | 4.2% | Apr 26, 2021 | Genoma Films |
| 34 | Valley of the Gods | - | - | - | $1,544 | 5 | $1,544 | 100% | Jun 3, 2021 | CG Entertainment |
| 35 | Hidden Away | - | - | - | $1,237 | 316 | $1,031,096 | 0.1% | Mar 4, 2020 | 01 Distribution |
| 36 | Wonder Woman 1984 | - | - | - | $1,140 | 43 | $38,160 | 3% | May 13, 2021 | Warner Bros. |
| 37 | Happy Together | - | - | - | $1,101 | 6 | $22,005 | 5% | May 21, 2021 | Tucker Film |
| 38 | Nomad: In the Footsteps of Bruce Chatwin | - | - | - | $1,080 | 28 | $90,654 | 1.2% | Oct 19, 2020 | Wanted |
| 39 | Fallen Angels 2021 Re-release | - | - | - | $981 | 3 | $2,105 | 46.6% | May 22, 2021 | Tucker Film |
| 40 | Tom & Jerry | - | - | - | $905 | 55 | $41,235 | 2.2% | May 13, 2021 | Warner Bros. |
| 41 | Rassegna Cinematografica | - | - | - | $895 | 61 | $1,486,466 | <0.1% | Sep 8, 2022 | - |
| 42 | Arab Blues | - | - | - | $886 | 172 | $598,007 | 0.1% | Apr 29, 2021 | BIM Distribuzione |
| 43 | Forward | - | - | - | $813 | 10 | $2,637 | 30.8% | May 27, 2021 | Officine UBU |
| 44 | L'occhio di vetro | - | - | - | $813 | 1 | $813 | 100% | Jun 4, 2021 | - |
| 45 | Corpus Christi | - | - | - | $811 | 36 | $67,167 | 1.2% | May 6, 2021 | Wanted |
| 46 | Emma. | - | - | - | $737 | 10 | $37,602 | 2% | Jun 16, 2020 | Universal Pictures International (UPI) |
| 47 | Misbehaviour | - | - | - | $692 | 67 | $42,836 | 1.6% | May 13, 2021 | BIM Distribuzione |
| 48 | Brooklyn 2021 Re-release | - | - | - | $645 | 1 | $326,014 | 0.2% | - | 20th Century Fox International |
| 49 | Gunda | - | - | - | $625 | 6 | $7,198 | 8.7% | May 13, 2021 | I Wonder Pictures |
| 50 | You Came Back | - | - | - | $567 | 365 | $432,688 | 0.1% | Oct 8, 2020 | Warner Bros. |
| 51 | Days of Being Wild 2021 Re-release | - | - | - | $524 | 2 | $1,585 | 33.1% | May 23, 2021 | Tucker Film |
| 52 | Honeyland | - | - | - | $507 | 3 | $25,895 | 2% | Feb 12, 2020 | - |
| 53 | The Predators | - | - | - | $495 | 357 | $206,589 | 0.2% | Oct 22, 2020 | 01 Distribution |
| 54 | As Tears Go By 2021 Re-release | - | - | - | $483 | 1 | $1,730 | 27.9% | May 24, 2021 | Tucker Film |
| 55 | Two of Us | - | - | - | $460 | 22 | $62,797 | 0.7% | May 6, 2021 | Teodora Film |
| 56 | The Bears' Famous Invasion of Sicily | - | - | - | $457 | 184 | $511,923 | <0.1% | Nov 7, 2019 | BIM Distribuzione |
