| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | A Quiet Place Part II | - | - | - | $55,696,693 | 3,744 | $160,072,261 | 34.8% | May 28, 2021 | Paramount Pictures |
| 2 | The Conjuring: The Devil Made Me Do It | - | - | - | $44,251,320 | 3,280 | $65,631,050 | 67.4% | Jun 4, 2021 | Warner Bros. |
| 3 | Cruella | - | - | - | $31,402,520 | 3,922 | $86,103,234 | 36.5% | May 28, 2021 | Walt Disney Studios Motion Pictures |
| 4 | Peter Rabbit 2: The Runaway | - | - | - | $12,258,074 | 3,346 | $40,501,717 | 30.3% | Jun 11, 2021 | Sony Pictures Releasing |
| 5 | Spirit Untamed | - | - | - | $11,630,790 | 3,394 | $17,716,215 | 65.7% | Jun 4, 2021 | Universal Pictures |
| 6 | In the Heights | - | - | - | $5,000,000 | 3,509 | $29,975,167 | 16.7% | Jun 11, 2021 | Warner Bros. |
| 7 | Wrath of Man | - | - | - | $3,494,361 | 3,007 | $27,466,489 | 12.7% | May 7, 2021 | United Artists Releasing |
| 8 | Spiral | - | - | - | $2,541,186 | 2,991 | $23,216,862 | 10.9% | May 14, 2021 | Lionsgate |
| 9 | Raya and the Last Dragon | - | - | - | $2,494,771 | 2,375 | $54,723,032 | 4.6% | Mar 5, 2021 | Walt Disney Studios Motion Pictures |
| 10 | Godzilla vs. Kong | - | - | - | $1,662,286 | 3,084 | $100,916,094 | 1.6% | Mar 31, 2021 | Warner Bros. |
| 11 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | - | - | - | $1,647,780 | 2,087 | $49,505,008 | 3.3% | Apr 23, 2021 | FUNimation Entertainment |
| 12 | The House Next Door: Meet the Blacks 2 | - | - | - | $1,007,775 | 539 | $2,893,660 | 34.8% | Jun 11, 2021 | Hidden Empire Film Group (HEFG) |
| 13 | Dream Horse | - | - | - | $713,698 | 1,284 | $2,913,328 | 24.5% | May 21, 2021 | Bleecker Street Media |
| 14 | Those Who Wish Me Dead | - | - | - | $587,067 | 3,379 | $7,407,200 | 7.9% | May 14, 2021 | Warner Bros. |
| 15 | Queen Bees | - | - | - | $523,110 | 600 | $1,926,706 | 27.2% | Jun 11, 2021 | Gravitas Ventures |
| 16 | Witnesses | - | - | - | $386,504 | 90 | $855,765 | 45.2% | Jun 4, 2021 | Purdie Distribution |
| 17 | Mortal Kombat | - | - | - | $311,414 | 3,114 | $42,326,031 | 0.7% | Apr 23, 2021 | Warner Bros. |
| 18 | 12 Mighty Orphans | - | - | - | $261,830 | 1,047 | $3,689,637 | 7.1% | Jun 11, 2021 | Sony Pictures Releasing |
| 19 | Finding You | - | - | - | $234,729 | 1,447 | $2,753,985 | 8.5% | May 14, 2021 | Roadside Attractions |
| 20 | Tom & Jerry | - | - | - | $216,485 | 2,563 | $46,536,687 | 0.5% | Feb 26, 2021 | Warner Bros. |
| 21 | The Croods: A New Age | - | - | - | $175,540 | 2,211 | $58,568,815 | 0.3% | Nov 25, 2020 | Universal Pictures |
| 22 | Nobody | - | - | - | $125,960 | 2,567 | $27,568,035 | 0.5% | Mar 26, 2021 | Universal Pictures |
| 23 | Here Today | - | - | - | $98,695 | 1,230 | $2,807,494 | 3.5% | May 7, 2021 | Stage 6 Films |
| 24 | The Unholy | - | - | - | $89,763 | 2,057 | $15,532,137 | 0.6% | Apr 2, 2021 | Screen Gems |
| 25 | The Dry | - | - | - | $81,511 | 186 | $364,237 | 22.4% | May 21, 2021 | IFC Films |
| 26 | Children of the Sea | - | - | - | $80,547 | 633 | $81,237 | 99.2% | Mar 20, 2020 | Fathom Events |
| 27 | The Truffle Hunters | - | - | - | $62,799 | 105 | $521,202 | 12% | Mar 5, 2021 | Sony Pictures Classics |
| 28 | Undine | - | - | - | $56,210 | 56 | $78,689 | 71.4% | Jun 4, 2021 | IFC Films |
| 29 | DOMINO: Battle of the Bones | - | - | - | $50,124 | - | $50,124 | 100% | Jun 11, 2021 | TriCoast Worldwide |
| 30 | Censor | - | - | - | $34,299 | 93 | $90,050 | 38.1% | Jun 11, 2021 | Magnolia Pictures |
| 31 | New Order | - | - | - | $28,940 | 236 | $303,556 | 9.5% | May 21, 2021 | Neon |
| 32 | The Courier | - | - | - | $27,378 | 1,641 | $6,613,432 | 0.4% | Mar 19, 2021 | Roadside Attractions |
| 33 | The Swimming Pool 2021 Re-release | - | - | - | $25,666 | 10 | $211,467 | 12.1% | May 14, 2021 | Rialto Distribution |
| 34 | Final Account | - | - | - | $24,981 | 308 | $308,976 | 8.1% | May 21, 2021 | Focus Features |
| 35 | Gully | - | - | - | $22,517 | 100 | $22,517 | 100% | Jun 4, 2021 | Vertical Entertainment |
| 36 | French Exit | - | - | - | $21,075 | 493 | $741,895 | 2.8% | Feb 12, 2021 | Sony Pictures Classics |
| 37 | Hero Mode | - | - | - | $20,472 | 46 | $21,178 | 96.7% | Jun 4, 2021 | Blue Fox Entertainment |
| 38 | Riders of Justice | - | - | - | $20,205 | 18 | $77,115 | 26.2% | May 14, 2021 | Magnolia Pictures |
| 39 | All Light, Everywhere | - | - | - | $17,629 | 19 | $37,266 | 47.3% | Jun 4, 2021 | Super LTD |
| 40 | Shiva Baby | - | - | - | $16,992 | 27 | $159,294 | 10.7% | Apr 2, 2021 | Utopia |
| 41 | Holler | - | - | - | $14,964 | 31 | $28,706 | 52.1% | Jun 11, 2021 | IFC Films |
| 42 | The Father | - | - | - | $14,416 | 933 | $2,122,771 | 0.7% | Feb 26, 2021 | Sony Pictures Classics |
| 43 | The Perfect Candidate | - | - | - | $12,896 | 17 | $30,134 | 42.8% | May 14, 2021 | Music Box Films |
| 44 | Together Together | - | - | - | $12,763 | 665 | $1,437,938 | 0.9% | Apr 23, 2021 | Bleecker Street Media |
| 45 | The Ladykillers 2021 Re-release | - | - | - | $11,847 | 3 | $23,213 | 51% | Jun 4, 2021 | Rialto Pictures |
| 46 | The Girl Who Believes in Miracles | - | - | - | $10,311 | 1,012 | $3,163,362 | 0.3% | Apr 2, 2021 | Atlas Distribution Company |
| 47 | Profile | - | - | - | $9,650 | 2,104 | $1,744,740 | 0.6% | May 14, 2021 | Focus Features |
| 48 | The War with Grandpa | - | - | - | $8,407 | 2,365 | $21,277,892 | <0.1% | Oct 9, 2020 | 101 Studios |
| 49 | Separation | - | - | - | $8,073 | 1,911 | $4,509,143 | 0.2% | Apr 30, 2021 | Open Road Films (II) |
| 50 | The Paper Tigers | - | - | - | $7,633 | 65 | $112,691 | 6.8% | May 7, 2021 | Well Go USA Entertainment |
| 51 | Final Frequency | - | - | - | $5,910 | 9 | $7,098 | 83.3% | Jun 11, 2021 | Integrity Releasing |
| 52 | The Killing of Two Lovers | - | - | - | $5,094 | 36 | $71,162 | 7.2% | May 14, 2021 | Neon |
| 53 | About Endlessness | - | - | - | $4,894 | 17 | $51,386 | 9.5% | Apr 30, 2021 | Magnolia Pictures |
| 54 | The Water Man | - | - | - | $3,873 | 311 | $383,234 | 1% | May 7, 2021 | RLJ Entertainment |
| 55 | The Djinn | - | - | - | $2,720 | 44 | $124,772 | 2.2% | May 14, 2021 | IFC Films |
| 56 | Mission Stories | - | - | - | $2,702 | 44 | $87,059 | 3.1% | May 7, 2021 | Excel Entertainment |
| 57 | Cliff Walkers | - | - | - | $2,646 | 65 | $152,972 | 1.7% | Apr 30, 2021 | CMC Pictures |
| 58 | My Love | - | - | - | $1,065 | 25 | $86,252 | 1.2% | May 7, 2021 | CMC Pictures |
| 59 | 100% Wolf | - | - | - | $1,017 | 124 | $658,764 | 0.2% | Oct 9, 2020 | Viva Pictures |
| 60 | Mainstream | - | - | - | $1,017 | 76 | $35,696 | 2.8% | May 7, 2021 | IFC Films |
| 61 | The Incredible 25th Year of Mitzi Bearclaw | - | - | - | $258 | 2 | $12,486 | 2.1% | Feb 12, 2021 | Indican Pictures |
| 62 | Funhouse | - | - | - | $216 | 3 | $507 | 42.6% | May 28, 2021 | Magnet Releasing |
| 63 | Ghost Master | - | - | - | $183 | 2 | $6,136 | 3% | May 14, 2021 | Indican Pictures |
| 64 | There Is No Evil | - | - | - | $123 | 7 | $8,063 | 1.5% | May 14, 2021 | Kino Lorber |
| 65 | The World to Come | - | - | - | $81 | 277 | $116,143 | <0.1% | Feb 12, 2021 | Bleecker Street Media |
| 66 | Lamb of God: The Concert Film | - | - | - | $10 | 138 | $744,813 | <0.1% | Mar 12, 2021 | Excel Entertainment |
