| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Avengers: Infinity War | - | - | - | $3,302,735 | 150 | $5,552,131 | 59.5% | Apr 27, 2018 | Ster-Kinekor Pictures |
| 2 | Deadpool 2 | - | - | - | $1,225,847 | 120 | $2,167,320 | 56.6% | May 18, 2018 | 20th Century Fox International |
| 3 | Acrimony | - | - | - | $628,230 | 74 | $1,851,141 | 33.9% | Mar 29, 2018 | Ster-Kinekor Pictures |
| 4 | Rampage | - | - | - | $378,284 | 131 | $1,214,656 | 31.1% | Apr 16, 2018 | Times Media Films |
| 5 | I Feel Pretty | - | - | - | $315,383 | 65 | $314,079 | 100.4% | May 4, 2018 | Ster-Kinekor Pictures |
| 6 | Sherlock Gnomes | - | - | - | $280,218 | 99 | $485,230 | 57.7% | May 11, 2018 | United International Pictures |
| 7 | Solo: A Star Wars Story | - | - | - | $190,264 | 119 | $349,967 | 54.4% | May 25, 2018 | Ster-Kinekor Pictures |
| 8 | Peter Rabbit | - | - | - | $171,453 | 104 | $1,764,414 | 9.7% | Mar 29, 2018 | Sony Pictures Releasing |
| 9 | Traffik | - | - | - | $169,296 | 49 | $202,799 | 83.5% | May 11, 2018 | Times Media Films |
| 10 | Maya the Bee: The Honey Games | - | - | - | $164,927 | 87 | $167,795 | 98.3% | May 4, 2018 | African Entertainment Distributors |
| 11 | Life of the Party | - | - | - | $140,220 | 53 | $224,353 | 62.5% | May 18, 2018 | Times Media Films |
| 12 | Blockers | - | - | - | $138,220 | 71 | $431,254 | 32.1% | Apr 20, 2018 | United International Pictures |
| 13 | I Can Only Imagine | - | - | - | $128,035 | 36 | $166,720 | 76.8% | May 11, 2018 | Ster-Kinekor Pictures |
| 14 | A Wrinkle in Time | - | - | - | $113,690 | 23 | $147,769 | 76.9% | May 4, 2018 | Ster-Kinekor Pictures |
| 15 | Early Man | - | - | - | $68,088 | 74 | $171,408 | 39.7% | Apr 20, 2018 | Times Media Films |
| 16 | Beirut | - | - | - | $50,068 | 14 | $74,891 | 66.9% | May 11, 2018 | Times Media Films |
| 17 | Wonderlus | - | - | - | $47,100 | 41 | $83,164 | 56.6% | Apr 27, 2018 | Indigenous Film Distribution |
| 18 | Madame | - | - | - | $42,684 | 14 | $68,718 | 62.1% | Apr 26, 2018 | Times Media Films |
| 19 | Tully | - | - | - | $42,441 | 25 | $42,441 | 100% | May 11, 2018 | Ster-Kinekor Pictures |
| 20 | Every Day | - | - | - | $40,545 | 40 | $40,545 | 100% | May 4, 2018 | Times Media Films |
| 21 | A Quiet Place | - | - | - | $31,929 | 28 | $269,759 | 11.8% | Apr 6, 2018 | United International Pictures |
| 22 | 102 Not Out | - | - | - | $27,337 | 8 | $27,658 | 98.8% | May 4, 2018 | Sony Pictures Releasing |
| 23 | Finding Your Feet | - | - | - | $24,275 | 18 | $67,474 | 36% | May 25, 2018 | Times Media Films |
| 24 | Mark Felt: The Man Who Brought Down the White House | - | - | - | $20,212 | 16 | $76,171 | 26.5% | Apr 20, 2018 | Ster-Kinekor Pictures |
| 25 | Five Fingers for Marseilles | - | - | - | $19,486 | 32 | $136,374 | 14.3% | Apr 6, 2018 | Indigenous Film Distribution |
| 26 | Susters | - | - | - | $18,425 | 40 | $326,415 | 5.6% | Mar 29, 2018 | Indigenous Film Distribution |
| 27 | A Wizard's Tale | - | - | - | $13,259 | 66 | $137,427 | 9.6% | Apr 13, 2018 | African Entertainment Distributors |
| 28 | Fifty Shades Freed | - | - | - | $8,439 | 112 | $2,616,471 | 0.3% | Feb 9, 2018 | United International Pictures |
| 29 | 7 Days in Entebbe | - | - | - | $7,885 | 25 | $115,640 | 6.8% | Apr 6, 2018 | Times Media Films |
| 30 | Please Stand By | - | - | - | $5,797 | 14 | $5,797 | 100% | May 25, 2018 | Ster-Kinekor Pictures |
| 31 | Journey's End | - | - | - | $5,527 | 6 | $5,527 | 100% | May 18, 2018 | Times Media Films |
| 32 | Unsane | - | - | - | $5,439 | 5 | $5,826 | 93.4% | May 4, 2018 | 20th Century Fox International |
| 33 | Lady Bird | - | - | - | $1,968 | 14 | $56,664 | 3.5% | Feb 23, 2018 | United International Pictures |
| 34 | Three Billboards Outside Ebbing, Missouri | - | - | - | $1,044 | 30 | $242,356 | 0.4% | Feb 23, 2018 | 20th Century Fox International |
| 35 | Darkest Hour | - | - | - | $556 | 24 | $173,634 | 0.3% | Feb 2, 2018 | United International Pictures |
| 36 | The Leisure Seeker | - | - | - | $541 | 12 | $56,870 | 1% | Mar 29, 2018 | Sony Pictures Releasing |
| 37 | Loving Vincent | - | - | - | $376 | 9 | $74,866 | 0.5% | Feb 23, 2018 | Indigenous Film Distribution |
| 38 | Pacific Rim: Uprising | - | - | - | $19 | 100 | $679,812 | <0.1% | Mar 23, 2018 | United International Pictures |
