| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Spud | - | - | - | $1,266,940 | 85 | $2,316,147 | 54.7% | Dec 3, 2010 | NuMetro Distribution |
| 2 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $1,062,781 | 112 | $2,268,033 | 46.9% | Nov 26, 2010 | NuMetro Distribution |
| 3 | The Chronicles of Narnia: The Voyage of the Dawn Treader | - | - | - | $798,044 | 113 | $1,931,605 | 41.3% | Dec 10, 2010 | NuMetro Distribution |
| 4 | Liefling | - | - | - | $774,468 | 97 | $1,842,887 | 42% | Nov 19, 2010 | Indigenous Film Distribution |
| 5 | RED | - | - | - | $294,354 | 45 | $815,188 | 36.1% | Nov 19, 2010 | NuMetro Distribution |
| 6 | Faster | - | - | - | $272,472 | 41 | $499,347 | 54.6% | Dec 3, 2010 | Ster-Kinekor Pictures |
| 7 | Unstoppable | - | - | - | $265,230 | 61 | $963,953 | 27.5% | Nov 12, 2010 | NuMetro Distribution |
| 8 | Life as We Know It | - | - | - | $251,084 | 70 | $1,172,038 | 21.4% | Oct 29, 2010 | NuMetro Distribution |
| 9 | Jackass 3D | - | - | - | $234,956 | 34 | $506,596 | 46.4% | Nov 19, 2010 | United International Pictures |
| 10 | Despicable Me | - | - | - | $227,339 | 86 | $2,345,587 | 9.7% | Oct 1, 2010 | United International Pictures |
| 11 | The American | - | - | - | $211,648 | 40 | $293,888 | 72% | Dec 3, 2010 | Ster-Kinekor Pictures |
| 12 | Eat Pray Love | - | - | - | $103,143 | 84 | $1,826,482 | 5.6% | Oct 8, 2010 | Sony Pictures Releasing |
| 13 | You Again | - | - | - | $95,611 | 30 | $394,708 | 24.2% | Nov 5, 2010 | Ster-Kinekor Pictures |
| 14 | Paranormal Activity 2 | - | - | - | $92,165 | 15 | $246,354 | 37.4% | Dec 10, 2010 | United International Pictures |
| 15 | Stoute Boudjies | - | - | - | $89,857 | 40 | $195,054 | 46.1% | Dec 10, 2010 | Ster-Kinekor Pictures |
| 16 | Takers 2010 Re-release | - | - | - | $71,216 | 40 | $460,076 | 15.5% | Oct 29, 2010 | Ster-Kinekor Pictures |
| 17 | Scott Pilgrim vs. the World | - | - | - | $63,958 | 15 | $86,677 | 73.8% | Dec 3, 2010 | United International Pictures |
| 18 | The Other Guys | - | - | - | $62,490 | 56 | $1,204,080 | 5.2% | Sep 24, 2010 | Sony Pictures Releasing |
| 19 | The Social Network | - | - | - | $46,631 | 40 | $415,980 | 11.2% | Nov 5, 2010 | Ster-Kinekor Pictures |
| 20 | The Girl Who Kicked the Hornet's Nest | - | - | - | $30,111 | 10 | $30,809 | 97.7% | Dec 10, 2010 | NuMetro Distribution |
| 21 | Why Did I Get Married Too? | - | - | - | $28,877 | 40 | $558,754 | 5.2% | Oct 1, 2010 | Ster-Kinekor Pictures |
| 22 | The Girl with the Dragon Tattoo | - | - | - | $28,618 | 15 | $276,717 | 10.3% | Oct 15, 2010 | NuMetro Distribution |
| 23 | The Girl Who Played with Fire | - | - | - | $24,678 | 14 | $148,095 | 16.7% | Nov 5, 2010 | NuMetro Distribution |
| 24 | Coco Chanel & Igor Stravinsky | - | - | - | $22,509 | 6 | $43,142 | 52.2% | Nov 26, 2010 | United International Pictures |
| 25 | Break Ke Baad | - | - | - | $20,002 | 6 | $35,021 | 57.1% | Nov 26, 2010 | NuMetro Distribution |
| 26 | Charlie St. Cloud | - | - | - | $17,857 | 45 | $291,268 | 6.1% | Oct 22, 2010 | United International Pictures |
| 27 | The Kids Are All Right | - | - | - | $14,392 | 3 | $58,624 | 24.5% | Nov 12, 2010 | United International Pictures |
| 28 | The Crazies | - | - | - | $13,748 | 34 | $77,597 | 17.7% | Nov 12, 2010 | United International Pictures |
| 29 | Eyes Wide Open | - | - | - | $7,408 | 2 | $30,933 | 23.9% | Nov 12, 2010 | United International Pictures |
