| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Sex and the City | - | - | - | $6,300,812 | 552 | $9,817,656 | 64.2% | May 30, 2008 | 01 Distribution |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $5,191,437 | 689 | $18,982,360 | 27.3% | May 23, 2008 | Universal Pictures International (UPI) |
| 3 | Gomorrah | - | - | - | $3,758,243 | 441 | $17,665,830 | 21.3% | May 16, 2008 | 01 Distribution |
| 4 | Il Divo | - | - | - | $3,757,826 | 358 | $8,517,653 | 44.1% | May 28, 2008 | Lucky Red |
| 5 | The Happening | - | - | - | $1,696,548 | 363 | $3,877,389 | 43.8% | Jun 12, 2008 | 20th Century Fox International |
| 6 | Made of Honor | - | - | - | $1,104,171 | 293 | $2,337,688 | 47.2% | Jun 12, 2008 | Sony Pictures Releasing |
| 7 | Then She Found Me | - | - | - | $833,987 | 142 | $940,111 | 88.7% | Jun 6, 2008 | Medusa Distribuzione |
| 8 | The Hitcher | - | - | - | $666,916 | 205 | $1,092,472 | 61% | May 30, 2008 | Medusa Distribuzione |
| 9 | One Missed Call | - | - | - | $595,294 | 109 | $747,957 | 79.6% | Jun 4, 2008 | Warner Bros. |
| 10 | Superhero Movie | - | - | - | $579,816 | 362 | $4,416,797 | 13.1% | May 16, 2008 | Medusa Distribuzione |
| 11 | What Happens in Vegas | - | - | - | $380,964 | 295 | $5,188,588 | 7.3% | May 9, 2008 | 20th Century Fox International |
| 12 | Once | - | - | - | $302,277 | 35 | $746,500 | 40.5% | May 30, 2008 | Sacher Distribuzione |
| 13 | Wild Blood | - | - | - | $259,387 | 215 | $932,866 | 27.8% | May 23, 2008 | 01 Distribution |
| 14 | Elite Squad | - | - | - | $170,455 | 56 | $228,296 | 74.7% | Jun 6, 2008 | Mikado Film |
| 15 | The Year My Parents Went on Vacation | - | - | - | $168,902 | 27 | $384,887 | 43.9% | Jun 6, 2008 | Lucky Red |
| 16 | Things We Lost in the Fire | - | - | - | $168,772 | 97 | $414,156 | 40.8% | Jun 12, 2008 | Teodora Film |
| 17 | Bratz | - | - | - | $143,624 | 149 | $150,460 | 95.5% | Jun 6, 2008 | Eagle Pictures |
| 18 | Feel the Noise | - | - | - | $140,366 | 118 | $244,011 | 57.5% | Jun 13, 2008 | Mediafilm |
| 19 | Maradona by Kusturica | - | - | - | $101,921 | 82 | $160,690 | 63.4% | May 30, 2008 | BIM Distribuzione |
| 20 | The Rest of the Night 2008 Re-release | - | - | - | $83,100 | 61 | $282,009 | 29.5% | Jun 11, 2008 | 01 Distribution |
| 21 | The Darjeeling Limited | - | - | - | $81,052 | 70 | $1,237,762 | 6.5% | Apr 30, 2008 | 20th Century Fox International |
| 22 | Mongol: The Rise of Genghis Khan | - | - | - | $71,796 | 137 | $1,325,000 | 5.4% | May 9, 2008 | BIM Distribuzione |
| 23 | The Girl by the Lake | - | - | - | $71,650 | 143 | $4,688,666 | 1.5% | Sep 14, 2007 | Medusa Distribuzione |
| 24 | In Bruges | - | - | - | $60,640 | 151 | $772,903 | 7.8% | May 16, 2008 | Mikado Film |
| 25 | Iron Man | - | - | - | $60,351 | 509 | $10,809,921 | 0.6% | May 1, 2008 | Universal Pictures International (UPI) |
| 26 | Before the Devil Knows You're Dead | - | - | - | $56,347 | 277 | $4,648,889 | 1.2% | Mar 14, 2008 | Medusa Distribuzione |
| 27 | Full of It | - | - | - | $51,562 | 29 | $89,878 | 57.4% | Jun 13, 2008 | Warner Bros. |
| 28 | 21 | - | - | - | $49,226 | 247 | $3,927,213 | 1.3% | Apr 18, 2008 | Sony Pictures Releasing |
| 29 | Be Kind Rewind | - | - | - | $40,048 | 95 | $220,443 | 18.2% | May 23, 2008 | BIM Distribuzione |
| 30 | Gli ultimi della strada | - | - | - | $34,850 | 252 | $1,062,945 | 3.3% | May 16, 2008 | 01 Distribution |
| 31 | Alexandra | - | - | - | $32,120 | 7 | $77,404 | 41.5% | May 30, 2008 | N/A |
| 32 | Charlie Bartlett | - | - | - | $29,799 | 31 | $51,943 | 57.4% | May 30, 2008 | DNC Entertainment |
| 33 | Horton Hears a Who! | - | - | - | $29,787 | 463 | $3,958,990 | 0.8% | Apr 18, 2008 | 20th Century Fox International |
| 34 | The Demons of St. Petersburg | - | - | - | $28,632 | 110 | $1,409,678 | 2% | Apr 24, 2008 | 01 Distribution |
| 35 | Rise: Blood Hunter | - | - | - | $27,901 | 127 | $326,477 | 8.5% | May 23, 2008 | Eagle Pictures |
| 36 | Tuttifrutti | - | - | - | $25,540 | 21 | $103,007 | 24.8% | May 16, 2008 | N/A |
| 37 | Non pensarci | - | - | - | $24,405 | 222 | $2,239,655 | 1.1% | Apr 4, 2008 | 01 Distribution |
| 38 | The Other Boleyn Girl | - | - | - | $23,002 | 102 | $2,180,712 | 1.1% | Apr 24, 2008 | Universal Pictures International (UPI) |
| 39 | August Rush | - | - | - | $22,292 | 190 | $1,462,687 | 1.5% | Nov 30, 2007 | Medusa Distribuzione |
| 40 | The Band's Visit | - | - | - | $20,230 | 51 | $919,800 | 2.2% | Mar 21, 2008 | Mikado Film |
| 41 | Evening | - | - | - | $18,635 | 180 | $1,160,067 | 1.6% | Apr 24, 2008 | Medusa Distribuzione |
| 42 | Underdog | - | - | - | $18,248 | 15 | $74,430 | 24.5% | May 16, 2008 | Walt Disney Pictures |
| 43 | The Night of the Sunflowers | - | - | - | $14,709 | 11 | $67,192 | 21.9% | Jun 13, 2008 | Istituto Luce |
| 44 | Woman's Hearts | - | - | - | $14,251 | 6 | $66,253 | 21.5% | Jun 13, 2008 | N/A |
| 45 | Shall We Kiss? | - | - | - | $9,575 | 36 | $140,508 | 6.8% | May 9, 2008 | N/A |
| 46 | The Zone | - | - | - | $9,193 | 27 | $312,516 | 2.9% | Apr 4, 2008 | Sacher Distribuzione |
| 47 | When Darkness Falls 2008 Re-release | - | - | - | $8,594 | 31 | $218,530 | 3.9% | May 2, 2008 | Teodora Film |
| 48 | The Wind Blows Round | - | - | - | $8,524 | 15 | $659,151 | 1.3% | May 4, 2007 | Aranciafilm |
| 49 | Tutto torna | - | - | - | $4,971 | 8 | $84,447 | 5.9% | May 9, 2008 | N/A |
| 50 | Questa notte è ancora nostra | - | - | - | $2,771 | 399 | $5,201,233 | <0.1% | Mar 20, 2008 | Walt Disney Pictures |
| 51 | Sfiorarsi | - | - | - | $2,207 | 2 | $15,722 | 14% | Feb 23, 2006 | N/A |
| 52 | Carnera: The Walking Mountain | - | - | - | $1,792 | 244 | $408,793 | 0.4% | May 9, 2008 | Medusa Distribuzione |
| 53 | Love Is Not Enough | - | - | - | $1,328 | 76 | $698,276 | 0.2% | Apr 18, 2008 | Mediafilm |
| 54 | There Will Be Blood | - | - | - | $889 | 111 | $2,566,966 | <0.1% | Feb 15, 2008 | Walt Disney Pictures |
| 55 | Gone Baby Gone | - | - | - | $879 | 16 | $115,103 | 0.8% | Apr 4, 2008 | Walt Disney Pictures |
| 56 | Speed Racer | - | - | - | $863 | 396 | $756,653 | 0.1% | May 9, 2008 | Warner Bros. |
| 57 | No Country for Old Men | - | - | - | $829 | 308 | $8,979,650 | <0.1% | Feb 22, 2008 | Universal Pictures International (UPI) |
