| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Mission: Impossible II | - | - | - | $36,294,088 | 3,669 | $215,409,889 | 16.8% | May 24, 2000 | Paramount Pictures |
| 2 | Big Momma's House | - | - | - | $30,978,483 | 2,854 | $117,559,438 | 26.4% | Jun 2, 2000 | 20th Century Fox |
| 3 | Dinosaur | - | - | - | $17,207,753 | 3,319 | $137,748,063 | 12.5% | May 19, 2000 | Walt Disney Studios Motion Pictures |
| 4 | Shanghai Noon | - | - | - | $12,008,990 | 2,751 | $56,937,502 | 21.1% | May 26, 2000 | Walt Disney Studios Motion Pictures |
| 5 | Gladiator | - | - | - | $11,751,791 | 3,188 | $187,705,427 | 6.3% | May 5, 2000 | DreamWorks Distribution |
| 6 | Road Trip | - | - | - | $9,935,237 | 2,654 | $68,540,777 | 14.5% | May 19, 2000 | DreamWorks Distribution |
| 7 | Frequency | - | - | - | $2,677,712 | 2,631 | $45,010,278 | 5.9% | Apr 28, 2000 | New Line Cinema |
| 8 | Small Time Crooks | - | - | - | $2,225,532 | 886 | $17,266,359 | 12.9% | May 19, 2000 | DreamWorks Distribution |
| 9 | U-571 | - | - | - | $2,137,020 | 2,820 | $77,122,415 | 2.8% | Apr 21, 2000 | Universal Pictures |
| 10 | Center Stage | - | - | - | $1,664,271 | 1,506 | $17,200,925 | 9.7% | May 12, 2000 | Sony Pictures Releasing |
| 11 | Where the Heart Is | - | - | - | $1,429,830 | 2,439 | $33,772,838 | 4.2% | Apr 28, 2000 | 20th Century Fox |
| 12 | The Flintstones in Viva Rock Vegas | - | - | - | $1,030,585 | 3,125 | $35,268,275 | 2.9% | Apr 28, 2000 | Universal Pictures |
| 13 | Erin Brockovich | - | - | - | $857,325 | 3,070 | $125,595,205 | 0.7% | Mar 17, 2000 | Universal Pictures |
| 14 | Michael Jordan to the Max | - | - | - | $572,131 | 56 | $18,650,521 | 3.1% | May 5, 2000 | IMAX |
| 15 | Rules of Engagement | - | - | - | $426,134 | 3,220 | $61,335,230 | 0.7% | Apr 7, 2000 | Paramount Pictures |
| 16 | Battlefield Earth | - | - | - | $426,095 | 3,307 | $21,471,685 | 2% | May 12, 2000 | Warner Bros. |
| 17 | The Big Kahuna | - | - | - | $353,243 | 309 | $3,165,544 | 11.2% | Apr 28, 2000 | Lionsgate |
| 18 | The Virgin Suicides | - | - | - | $339,482 | 275 | $4,906,229 | 6.9% | Apr 21, 2000 | Paramount Classics |
| 19 | East Is East | - | - | - | $319,565 | 157 | $4,177,818 | 7.6% | Apr 14, 2000 | Miramax |
| 20 | Wolves | - | - | - | $289,159 | 16 | $4,811,282 | 6% | Jun 18, 1999 | IMAX |
| 21 | Cirque du Soleil: Journey of Man | - | - | - | $265,152 | 22 | $15,627,434 | 1.7% | May 5, 2000 | Sony Pictures Classics |
| 22 | The Road to El Dorado | - | - | - | $258,198 | 3,223 | $50,863,742 | 0.5% | Mar 31, 2000 | DreamWorks Distribution |
| 23 | T-Rex: Back to the Cretaceous | - | - | - | $256,007 | 38 | $53,354,743 | 0.5% | Oct 23, 1998 | IMAX |
| 24 | High Fidelity | - | - | - | $244,565 | 1,231 | $27,287,137 | 0.9% | Mar 31, 2000 | Walt Disney Studios Motion Pictures |
| 25 | Up at the Villa | - | - | - | $244,069 | 112 | $2,933,161 | 8.3% | May 5, 2000 | USA Films |
| 26 | Love & Basketball | - | - | - | $237,549 | 1,245 | $27,459,615 | 0.9% | Apr 21, 2000 | New Line Cinema |
| 27 | Held Up | - | - | - | $234,171 | 688 | $4,705,631 | 5% | May 12, 2000 | Trimark Pictures |
| 28 | Final Destination | - | - | - | $213,983 | 2,587 | $53,331,147 | 0.4% | Mar 17, 2000 | New Line Cinema |
| 29 | Mysteries of Egypt | - | - | - | $210,857 | 27 | $40,593,486 | 0.5% | Aug 21, 1998 | IMAX |
| 30 | Galapagos | - | - | - | $200,611 | 14 | $18,630,372 | 1.1% | Oct 29, 1999 | IMAX |
| 31 | 28 Days | - | - | - | $179,740 | 2,523 | $37,170,488 | 0.5% | Apr 14, 2000 | Sony Pictures Releasing |
| 32 | My Dog Skip | - | - | - | $174,565 | 2,331 | $34,134,641 | 0.5% | Jan 14, 2000 | Warner Bros. |
| 33 | Passion of Mind | - | - | - | $171,401 | 122 | $769,272 | 22.3% | May 26, 2000 | Paramount Classics |
| 34 | The Cider House Rules | - | - | - | $166,517 | 1,738 | $57,545,092 | 0.3% | Dec 10, 1999 | Miramax |
| 35 | Kikujiro | - | - | - | $166,025 | 4 | $200,920 | 82.6% | May 26, 2000 | Sony Pictures Classics |
| 36 | Romeo Must Die | - | - | - | $165,833 | 2,641 | $55,973,336 | 0.3% | Mar 22, 2000 | Warner Bros. |
| 37 | The Tigger Movie | - | - | - | $165,436 | 2,818 | $45,554,533 | 0.4% | Feb 11, 2000 | Walt Disney Studios Motion Pictures |
| 38 | Hamlet | - | - | - | $157,207 | 65 | $1,577,287 | 10% | May 12, 2000 | Miramax |
| 39 | Snow Day | - | - | - | $154,364 | 2,717 | $60,020,107 | 0.3% | Feb 11, 2000 | Paramount Pictures |
| 40 | Bossa Nova | - | - | - | $150,489 | 59 | $1,823,297 | 8.3% | Apr 28, 2000 | Sony Pictures Releasing |
| 41 | American Psycho | - | - | - | $142,928 | 1,242 | $15,070,285 | 0.9% | Apr 14, 2000 | Lionsgate |
| 42 | Croupier | - | - | - | $140,638 | 141 | $6,201,143 | 2.3% | Apr 21, 2000 | - |
| 43 | Screwed | - | - | - | $139,905 | 1,761 | $7,027,345 | 2% | May 12, 2000 | Universal Pictures |
| 44 | Timecode | - | - | - | $126,763 | 130 | $1,057,750 | 12% | Apr 28, 2000 | Sony Pictures Releasing |
| 45 | East/West | - | - | - | $119,931 | 70 | $2,321,029 | 5.2% | Apr 7, 2000 | Sony Pictures Classics |
| 46 | Mission to Mars | - | - | - | $117,596 | 3,101 | $60,883,407 | 0.2% | Mar 10, 2000 | Walt Disney Studios Motion Pictures |
| 47 | Return to Me | - | - | - | $105,011 | 2,320 | $32,722,798 | 0.3% | Apr 7, 2000 | Metro-Goldwyn-Mayer (MGM) |
| 48 | Toy Story 2 | - | - | - | $104,546 | 3,257 | $245,852,179 | <0.1% | Nov 19, 1999 | Walt Disney Studios Motion Pictures |
| 49 | Scream 3 | - | - | - | $101,991 | 3,467 | $89,143,175 | 0.1% | Feb 4, 2000 | Dimension Films |
| 50 | The Color of Paradise | - | - | - | $96,556 | 33 | $1,817,216 | 5.3% | Mar 31, 2000 | Sony Pictures Classics |
| 51 | I Dreamed of Africa | - | - | - | $96,452 | 2,112 | $6,651,522 | 1.5% | May 5, 2000 | Sony Pictures Releasing |
| 52 | Alien Adventure | - | - | - | $89,830 | 10 | $8,959,784 | 1% | Aug 20, 1999 | nWave Pictures |
| 53 | Siegfried & Roy: The Magic Box | - | - | - | $83,087 | 22 | $5,231,283 | 1.6% | Oct 1, 1999 | IMAX |
| 54 | God's Army | - | - | - | $71,293 | 50 | $2,637,726 | 2.7% | Mar 10, 2000 | Zion Films |
| 55 | 8 ½ Women | - | - | - | $66,757 | 30 | $424,123 | 15.7% | May 26, 2000 | Lionsgate |
| 56 | Africa's Elephant Kingdom | - | - | - | $62,425 | 15 | $13,485,455 | 0.5% | May 1, 1998 | IMAX |
| 57 | Running Free | - | - | - | $62,157 | 100 | $117,608 | 52.9% | Jun 2, 2000 | Sony Pictures Releasing |
| 58 | Keeping the Faith | - | - | - | $41,833 | 2,171 | $37,047,880 | 0.1% | Apr 14, 2000 | Walt Disney Studios Motion Pictures |
| 59 | American Beauty | - | - | - | $38,554 | 1,990 | $130,096,601 | <0.1% | Sep 15, 1999 | DreamWorks Distribution |
| 60 | Grass | - | - | - | $28,290 | 10 | $313,039 | 9% | May 31, 2000 | Unapix Entertainment Productions |
| 61 | New Waterford Girl | - | - | - | $25,770 | 20 | $774,469 | 3.3% | Jun 2, 2000 | Odeon |
| 62 | Whatever It Takes | - | - | - | $20,151 | 2,272 | $8,745,680 | 0.2% | Mar 24, 2000 | Sony Pictures Releasing |
| 63 | The Skulls | - | - | - | $13,275 | 2,416 | $35,046,120 | <0.1% | Mar 31, 2000 | Universal Pictures |
| 64 | All About My Mother | - | - | - | $7,859 | 145 | $8,272,296 | <0.1% | Nov 5, 1999 | Sony Pictures Classics |
| 65 | Better Living Through Circuitry | - | - | - | $5,320 | 8 | $82,378 | 6.5% | May 26, 2000 | Seventh Art Releasing |
| 66 | Groove | - | - | - | $4,585 | 50 | $1,115,313 | 0.4% | Jun 9, 2000 | Sony Pictures Releasing |
| 67 | Bicentennial Man | - | - | - | $2,391 | 2,767 | $58,223,861 | <0.1% | Dec 17, 1999 | Walt Disney Studios Motion Pictures |
