| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | Nutty Professor II: The Klumps | - | - | - | $4,538,015 | 3,251 | $123,309,890 | 3.7% | Jul 28, 2000 | Universal Pictures |
| 2 | What Lies Beneath | - | - | - | $3,406,274 | 2,925 | $155,464,351 | 2.2% | Jul 21, 2000 | DreamWorks Distribution |
| 3 | Chicken Run | - | - | - | $2,409,081 | 2,953 | $106,834,564 | 2.3% | Jun 23, 2000 | DreamWorks Distribution |
| 4 | X-Men | - | - | - | $1,872,869 | 3,112 | $157,299,718 | 1.2% | Jul 14, 2000 | Twentieth Century Fox |
| 5 | Scary Movie | - | - | - | $1,243,306 | 3,301 | $157,019,771 | 0.8% | Jul 7, 2000 | Miramax |
| 6 | The Perfect Storm | - | - | - | $1,004,682 | 3,407 | $182,618,434 | 0.6% | Jun 30, 2000 | Warner Bros. |
| 7 | The Kid | - | - | - | $921,371 | 2,343 | $69,691,949 | 1.3% | Jul 7, 2000 | Walt Disney Studios Motion Pictures |
| 8 | Pokémon the Movie 2000 | - | - | - | $887,831 | 2,752 | $43,758,684 | 2% | Jul 21, 2000 | Warner Bros. |
| 9 | Thomas and the Magic Railroad | - | - | - | $641,328 | 2,110 | $15,933,506 | 4% | Jul 26, 2000 | Destination Films |
| 10 | The Patriot | - | - | - | $619,445 | 3,061 | $113,330,342 | 0.5% | Jun 28, 2000 | Sony Pictures Releasing |
| 11 | The in Crowd | - | - | - | $561,290 | 1,357 | $5,280,035 | 10.6% | Jul 21, 2000 | Warner Bros. |
| 12 | Loser | - | - | - | $510,316 | 2,016 | $15,618,626 | 3.3% | Jul 21, 2000 | Sony Pictures Releasing |
| 13 | Michael Jordan to the Max | - | - | - | $247,326 | 56 | $18,650,521 | 1.3% | May 5, 2000 | IMAX |
| 14 | Cirque du Soleil: Journey of Man | - | - | - | $240,770 | 22 | $15,627,434 | 1.5% | May 5, 2000 | Sony Pictures Classics |
| 15 | Me, Myself & Irene | - | - | - | $226,754 | 3,087 | $90,570,999 | 0.3% | Jun 23, 2000 | Twentieth Century Fox |
| 16 | Shaft | - | - | - | $199,082 | 2,433 | $70,334,258 | 0.3% | Jun 16, 2000 | Paramount Pictures |
| 17 | Gladiator | - | - | - | $145,329 | 3,188 | $187,705,427 | <0.1% | May 5, 2000 | DreamWorks Distribution |
| 18 | Mysteries of Egypt | - | - | - | $135,512 | 27 | $40,593,486 | 0.3% | Aug 21, 1998 | IMAX |
| 19 | Gone in 60 Seconds | - | - | - | $129,915 | 3,089 | $101,648,571 | 0.1% | Jun 9, 2000 | Walt Disney Studios Motion Pictures |
| 20 | But I'm a Cheerleader | - | - | - | $123,915 | 115 | $2,205,627 | 5.6% | Jul 7, 2000 | Lionsgate |
| 21 | Croupier | - | - | - | $122,117 | 141 | $6,201,143 | 2% | Apr 21, 2000 | - |
| 22 | Mission: Impossible II | - | - | - | $115,806 | 3,669 | $215,409,889 | <0.1% | May 24, 2000 | Paramount Pictures |
| 23 | Dinosaur | - | - | - | $111,249 | 3,319 | $137,748,063 | <0.1% | May 19, 2000 | Walt Disney Studios Motion Pictures |
| 24 | T-Rex: Back to the Cretaceous | - | - | - | $110,485 | 38 | $53,354,743 | 0.2% | Oct 23, 1998 | IMAX |
| 25 | The Adventures of Rocky & Bullwinkle | - | - | - | $107,250 | 2,482 | $26,005,820 | 0.4% | Jun 30, 2000 | Universal Pictures |
| 26 | Big Momma's House | - | - | - | $105,553 | 2,854 | $117,559,438 | <0.1% | Jun 2, 2000 | Twentieth Century Fox |
| 27 | Galapagos | - | - | - | $102,093 | 14 | $18,630,372 | 0.5% | Oct 29, 1999 | IMAX |
| 28 | Titan A.E. | - | - | - | $96,222 | 2,775 | $22,753,426 | 0.4% | Jun 16, 2000 | Twentieth Century Fox |
| 29 | Blood Simple 2000 Re-release | - | - | - | $91,534 | 68 | $1,701,855 | 5.4% | Jul 7, 2000 | USA Films |
| 30 | Final Destination | - | - | - | $73,151 | 2,587 | $53,331,147 | 0.1% | Mar 17, 2000 | New Line Cinema |
| 31 | Road Trip | - | - | - | $69,208 | 2,654 | $68,540,777 | 0.1% | May 19, 2000 | DreamWorks Distribution |
| 32 | Chuck & Buck | - | - | - | $66,474 | 46 | $1,055,671 | 6.3% | Jul 14, 2000 | Artisan Entertainment |
| 33 | Jesus' Son | - | - | - | $63,272 | 95 | $1,302,067 | 4.9% | Jun 16, 2000 | Lionsgate |
| 34 | Siegfried & Roy: The Magic Box | - | - | - | $60,799 | 22 | $5,231,283 | 1.2% | Oct 1, 1999 | IMAX |
| 35 | Love & Basketball | - | - | - | $55,345 | 1,245 | $27,459,615 | 0.2% | Apr 21, 2000 | New Line Cinema |
| 36 | Where the Heart Is | - | - | - | $51,114 | 2,439 | $33,772,838 | 0.2% | Apr 28, 2000 | Twentieth Century Fox |
| 37 | Thrill Ride: The Science of Fun | - | - | - | $50,015 | 81 | $18,798,590 | 0.3% | Jul 11, 1997 | Sony Pictures Classics |
| 38 | Alien Adventure | - | - | - | $48,735 | 10 | $8,959,784 | 0.5% | Aug 20, 1999 | nWave Pictures |
| 39 | The Five Senses | - | - | - | $46,797 | 39 | $497,091 | 9.4% | Jul 14, 2000 | Fine Line Features |
| 40 | Return to Me | - | - | - | $42,637 | 2,320 | $32,722,798 | 0.1% | Apr 7, 2000 | Metro-Goldwyn-Mayer (MGM) |
| 41 | Shanghai Noon | - | - | - | $42,532 | 2,751 | $56,937,502 | <0.1% | May 26, 2000 | Walt Disney Studios Motion Pictures |
| 42 | High Fidelity | - | - | - | $41,869 | 1,231 | $27,287,137 | 0.2% | Mar 31, 2000 | Walt Disney Studios Motion Pictures |
| 43 | Shower | - | - | - | $38,211 | 46 | $1,157,764 | 3.3% | Jul 7, 2000 | Sony Pictures Releasing |
| 44 | Butterfly | - | - | - | $37,991 | 72 | $2,092,682 | 1.8% | Jun 16, 2000 | Miramax |
| 45 | The Girl on the Bridge | - | - | - | $31,867 | 48 | $1,708,839 | 1.9% | Jul 28, 2000 | Paramount Classics |
| 46 | U-571 | - | - | - | $28,725 | 2,820 | $77,122,415 | <0.1% | Apr 21, 2000 | Universal Pictures |
| 47 | Frequency | - | - | - | $26,973 | 2,631 | $45,010,278 | <0.1% | Apr 28, 2000 | New Line Cinema |
| 48 | The Flintstones in Viva Rock Vegas | - | - | - | $26,565 | 3,125 | $35,268,275 | <0.1% | Apr 28, 2000 | Universal Pictures |
| 49 | 28 Days | - | - | - | $24,673 | 2,523 | $37,170,488 | <0.1% | Apr 14, 2000 | Sony Pictures Releasing |
| 50 | The Eyes of Tammy Faye | - | - | - | $24,630 | 51 | $1,029,591 | 2.4% | Jul 21, 2000 | Lionsgate |
| 51 | East Is East | - | - | - | $22,709 | 157 | $4,177,818 | 0.5% | Apr 14, 2000 | Miramax |
| 52 | The Life and Times of Hank Greenberg | - | - | - | $20,182 | 31 | $1,712,385 | 1.2% | Jan 12, 2000 | Cowboy Pictures |
| 53 | Wonderland | - | - | - | $19,609 | 25 | $414,254 | 4.7% | Jul 28, 2000 | USA Films |
| 54 | The Virgin Suicides | - | - | - | $17,358 | 275 | $4,906,229 | 0.4% | Apr 21, 2000 | Paramount Classics |
| 55 | Erin Brockovich | - | - | - | $15,950 | 3,070 | $125,595,205 | <0.1% | Mar 17, 2000 | Universal Pictures |
| 56 | The Wind Will Carry Us | - | - | - | $14,816 | 2 | $259,510 | 5.7% | Jul 28, 2000 | New Yorker Films |
| 57 | Small Time Crooks | - | - | - | $7,164 | 886 | $17,266,359 | <0.1% | May 19, 2000 | DreamWorks Distribution |
