| Rank
| Release
| Genre
| Budget
| Running Time
| Gross | Max Theaters | Total Gross | % of Total | Release Date | Distributor
|
|---|
| 1 | What About Bob? | - | - | - | $20,040,901 | 1,805 | $63,707,829 | 31.5% | May 17, 1991 | Walt Disney Studios Motion Pictures |
| 2 | Backdraft | - | - | - | $15,723,480 | 1,983 | $77,868,585 | 20.2% | May 24, 1991 | Universal Pictures |
| 3 | Oscar | - | - | - | $14,791,472 | 1,391 | $23,562,716 | 62.8% | Apr 26, 1991 | Walt Disney Studios Motion Pictures |
| 4 | F/X2 | - | - | - | $14,252,211 | 1,502 | $21,082,165 | 67.6% | May 10, 1991 | Orion Pictures |
| 5 | One Good Cop | - | - | - | $11,276,846 | 1,454 | $11,276,846 | 100% | May 3, 1991 | Walt Disney Studios Motion Pictures |
| 6 | Switch | - | - | - | $10,979,608 | 1,013 | $15,545,943 | 70.6% | May 10, 1991 | Warner Bros. |
| 7 | The Silence of the Lambs | - | - | - | $10,826,232 | 1,642 | $130,742,922 | 8.3% | Feb 14, 1991 | Orion Pictures |
| 8 | Out for Justice | - | - | - | $10,806,920 | 2,010 | $39,673,161 | 27.2% | Apr 12, 1991 | Warner Bros. |
| 9 | A Rage in Harlem | - | - | - | $10,438,504 | 545 | $10,438,504 | 100% | May 3, 1991 | Miramax |
| 10 | Toy Soldiers | - | - | - | $9,717,142 | 1,358 | $15,073,942 | 64.5% | Apr 26, 1991 | TriStar Pictures |
| 11 | A Kiss Before Dying | - | - | - | $9,681,692 | 1,546 | $15,429,177 | 62.7% | Apr 26, 1991 | Universal Pictures |
| 12 | Teenage Mutant Ninja Turtles II: The Secret of the Ooze | - | - | - | $8,457,212 | 2,868 | $78,656,813 | 10.8% | Mar 22, 1991 | New Line Cinema |
| 13 | Dances with Wolves | - | - | - | $8,198,186 | 1,636 | $184,208,848 | 4.5% | Nov 9, 1990 | Orion Pictures |
| 14 | Mortal Thoughts | - | - | - | $8,003,821 | 1,196 | $18,784,957 | 42.6% | Apr 19, 1991 | Columbia Pictures |
| 15 | New Jack City | - | - | - | $7,786,074 | 905 | $47,624,353 | 16.3% | Mar 8, 1991 | Warner Bros. |
| 16 | Madonna: Truth or Dare | - | - | - | $7,716,121 | 652 | $15,012,935 | 51.4% | May 10, 1991 | Miramax |
| 17 | Stone Cold | - | - | - | $5,172,591 | 1,729 | $9,151,887 | 56.5% | May 17, 1991 | Columbia Pictures |
| 18 | Hudson Hawk | - | - | - | $4,834,304 | 2,072 | $17,218,080 | 28.1% | May 24, 1991 | TriStar Pictures |
| 19 | Thelma & Louise | - | - | - | $4,424,764 | 1,180 | $45,360,915 | 9.8% | May 24, 1991 | Metro-Goldwyn-Mayer (MGM) |
| 20 | Only the Lonely | - | - | - | $4,122,484 | 1,553 | $21,830,957 | 18.9% | May 24, 1991 | Twentieth Century Fox |
| 21 | Defending Your Life | - | - | - | $3,630,550 | 715 | $16,371,128 | 22.2% | Mar 22, 1991 | Warner Bros. |
| 22 | Sleeping with the Enemy | - | - | - | $3,095,639 | 1,545 | $101,599,005 | 3% | Feb 8, 1991 | Twentieth Century Fox |
| 23 | Drop Dead Fred | - | - | - | $2,709,732 | 933 | $13,878,334 | 19.5% | May 24, 1991 | New Line Cinema |
| 24 | Eating | - | - | - | $2,081,718 | 19 | $2,100,538 | 99.1% | Nov 16, 1990 | Rainbow Releasing |
| 25 | Mannequin: On the Move | - | - | - | $2,081,163 | 1,540 | $3,752,428 | 55.5% | May 17, 1991 | Twentieth Century Fox |
| 26 | Ju Dou | - | - | - | $1,967,488 | 39 | $1,986,433 | 99% | Mar 6, 1991 | Miramax |
| 27 | Wild Hearts Can't Be Broken | - | - | - | $1,794,372 | 1,662 | $7,294,835 | 24.6% | May 24, 1991 | Walt Disney Studios Motion Pictures |
| 28 | Spartacus 1991 Re-release | - | - | - | $1,725,683 | 52 | $1,830,650 | 94.3% | Apr 26, 1991 | Universal Pictures |
| 29 | Kindergarten Cop | - | - | - | $1,201,823 | 1,937 | $91,457,688 | 1.3% | Dec 22, 1990 | Universal Pictures |
| 30 | The Godfather Part III | - | - | - | $920,156 | 1,922 | $66,666,062 | 1.4% | Dec 25, 1990 | Paramount Pictures |
| 31 | Rosencrantz & Guildenstern Are Dead | - | - | - | $705,286 | 18 | $739,104 | 95.4% | Feb 8, 1991 | Cinecom Pictures |
| 32 | Rich Girl | - | - | - | $561,000 | 1,058 | $561,000 | 100% | May 3, 1991 | - |
| 33 | Home Alone | - | - | - | $397,202 | 2,173 | $285,761,243 | 0.1% | Nov 16, 1990 | Twentieth Century Fox |
| 34 | Sweet Talker | - | - | - | $382,510 | 409 | $382,510 | 100% | May 10, 1991 | New Line Cinema |
| 35 | True Colors | - | - | - | $330,027 | 9 | $418,807 | 78.8% | Mar 15, 1991 | Paramount Pictures |
| 36 | Journey of Hope | - | - | - | $241,995 | 18 | $261,718 | 92.5% | Apr 26, 1991 | Miramax |
| 37 | The Ballad of the Sad Cafe | - | - | - | $184,890 | 1 | $184,890 | 100% | May 3, 1991 | - |
| 38 | Open Doors | - | - | - | $102,178 | 6 | $123,470 | 82.8% | Mar 8, 1991 | Orion Classics |
| 39 | Straight Out of Brooklyn | - | - | - | $56,754 | 75 | $2,712,293 | 2.1% | May 22, 1991 | The Samuel Goldwyn Company |
| 40 | Auntie Danielle | - | - | - | $32,485 | 17 | $604,624 | 5.4% | May 17, 1991 | Miramax |
| 41 | Opening Night | - | - | - | $23,488 | 1 | $23,488 | 100% | May 17, 1991 | Castle Hill Productions |
| 42 | An Angel at My Table | - | - | - | $19,890 | 20 | $1,054,638 | 1.9% | May 17, 1991 | Fine Line Features |
| 43 | Truly Madly Deeply | - | - | - | $11,233 | 48 | $1,554,742 | 0.7% | May 3, 1991 | The Samuel Goldwyn Company |
| 44 | Thousand Pieces of Gold | - | - | - | $6,756 | 10 | $717,772 | 0.9% | Apr 26, 1991 | - |
