| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Dune: Part One | - | - | - | $5,692,596 | 488 | $8,082,849 | Sep 16 | Warner Bros. | false |
| 2 | Shang-Chi and the Legend of the Ten Rings | - | - | - | $4,255,241 | 403 | $4,561,454 | Sep 1 | Walt Disney Studios Motion Pictures | false |
| 3 | Like a Cat on a Highway 2 | - | - | - | $1,822,294 | 482 | $3,664,181 | Aug 26 | - | false |
| 4 | Space Jam: A New Legacy | - | - | - | $1,750,705 | 411 | $3,526,811 | Sep 23 | Universal Pictures International (UPI) | false |
| 5 | Me contro te - Il mistero della scuola incantata | - | - | - | $1,085,920 | 446 | $5,879,431 | Aug 19 | Warner Bros. | false |
| 6 | Three Floors | - | - | - | $994,417 | 383 | $2,252,671 | Sep 23 | 01 Distribution | false |
| 7 | F9: The Fast Saga | - | - | - | $953,822 | 422 | $5,771,546 | Aug 18 | Universal Pictures International (UPI) | false |
| 8 | Escape Room: Tournament of Champions | - | - | - | $716,188 | 138 | $696,494 | Sep 23 | Warner Bros. | false |
| 9 | Malignant | - | - | - | $493,339 | 255 | $493,339 | Sep 2 | Warner Bros. | false |
| 10 | The Card Counter | - | - | - | $432,855 | 244 | $482,136 | Sep 3 | STX International | false |
| 11 | Still Out of My League | - | - | - | $238,916 | 331 | $251,116 | Sep 16 | Paramount Pictures | false |
| 12 | Supernova | - | - | - | $222,152 | 111 | $270,195 | Sep 16 | Lucky Red | false |
| 13 | Welcome Venice | - | - | - | $185,865 | 65 | $185,865 | Sep 9 | Lucky Red | false |
| 14 | Free Guy | - | - | - | $126,429 | 260 | $1,028,120 | Aug 11 | Walt Disney Studios Motion Pictures | false |
| 15 | Mondocane | - | - | - | $125,835 | 183 | $125,835 | Sep 2 | 01 Distribution | false |
| 16 | Il silenzio grande | - | - | - | $111,799 | 109 | $143,248 | Sep 16 | - | false |
| 17 | Jungle Cruise | - | - | - | $88,209 | 327 | $2,004,813 | Jul 28 | Walt Disney Studios Motion Pictures | false |
| 18 | Welcome at Esposito's | - | - | - | $75,308 | 30 | $148,642 | Sep 23 | - | false |
| 19 | The Suicide Squad | - | - | - | $73,533 | 321 | $2,272,641 | May 8 | Warner Bros. | false |
| 20 | Wheel of Fortune and Fantasy | - | - | - | $51,097 | 37 | $102,212 | Jul 1 | Tucker Film | false |
| 21 | Rosa's Wedding | - | - | - | $48,878 | 36 | $64,882 | Sep 16 | Officine UBU | false |
| 22 | The Hole | - | - | - | $44,367 | 24 | $94,631 | Sep 23 | Lucky Red | false |
| 23 | Drive My Car | - | - | - | $40,805 | 32 | $303,318 | Sep 23 | Tucker Film | false |
| 24 | Raya and the Last Dragon | - | - | - | $23,664 | 158 | $146,674 | Jun 24 | Walt Disney Studios Motion Pictures | false |
| 25 | Falling | - | - | - | $22,997 | 119 | $108,250 | Aug 26 | BIM Distribuzione | false |
| 26 | Reminiscence | - | - | - | $21,859 | 275 | $178,032 | Aug 26 | Warner Bros. | false |
| 27 | Candyman | - | - | - | $21,259 | 214 | $190,404 | Aug 26 | Paramount Pictures | false |
| 28 | Titane | - | - | - | $19,790 | 59 | $123,186 | Sep 30 | I Wonder Pictures | false |
| 29 | Spin Time, che fatica la democrazia! | - | - | - | $9,611 | 17 | $9,611 | Sep 16 | Wanted | false |
| 30 | Marx Can Wait | - | - | - | $8,194 | 72 | $205,917 | Jul 15 | 01 Distribution | false |
| 31 | The Father | - | - | - | $7,976 | 338 | $1,447,821 | May 27 | BIM Distribuzione | false |
| 32 | The Girl with a Bracelet | - | - | - | $7,752 | 37 | $56,604 | Aug 19 | Satine Film | false |
| 33 | Blue Bayou | - | - | - | $7,429 | 56 | $7,429 | Sep 16 | Universal Pictures International (UPI) | false |
| 34 | Europa 2021 Re-release | - | - | - | $7,275 | 16 | $7,275 | Mar 9 | I Wonder Pictures | false |
| 35 | Another Round | - | - | - | $7,109 | 242 | $815,062 | May 20 | Medusa Distribuzione | false |
| 36 | Black Widow | - | - | - | $4,375 | 366 | $5,776,237 | Jul 7 | Walt Disney Studios Motion Pictures | false |
| 37 | The Shiny Shrimps | - | - | - | $190 | 15 | $47,351 | Jul 9 | Movies Inspired | false |
| 38 | Yesterday | - | - | - | $86 | 369 | $1,082,927 | Sep 26 | Universal Pictures International (UPI) | false |
