Domestic Box Office For September 2010
Wide releases are those released in at least 600 theaters.
| Rank | Release | Gross | Max Th | Opening | % of Total | Open Th | Open | Close | Distributor |
|---|---|---|---|---|---|---|---|---|---|
| 1 | The Town | $92,186,262 | 2,935 | $23,808,032 | 25.8% | 2,861 | Sep 17 | Jan 6 | Warner Bros. |
| 2 | Resident Evil: Afterlife | $60,128,566 | 3,209 | $26,650,264 | 44.3% | 3,203 | Sep 10 | Nov 4 | Screen Gems |
| 3 | Easy A | $58,401,464 | 2,974 | $17,734,040 | 30.4% | 2,856 | Sep 17 | Dec 23 | Screen Gems |
| 4 | Legend of the Guardians: The Owls of Ga'Hoole | $55,675,313 | 3,575 | $16,112,211 | 28.9% | 3,575 | Sep 24 | Jan 20 | Warner Bros. |
| 5 | Wall Street: Money Never Sleeps | $52,474,616 | 3,597 | $19,011,188 | 36.2% | 3,565 | Sep 24 | Dec 19 | Twentieth Century Fox |
| 6 | The American | $35,606,376 | 2,833 | $13,177,790 | 37% | 2,823 | Sep 1 | Nov 4 | Focus Features |
| 7 | Devil | $33,601,190 | 2,811 | $12,289,375 | 36.6% | 2,809 | Sep 17 | Nov 18 | Universal Pictures |
| 8 | Machete | $26,593,646 | 2,678 | $11,416,164 | 42.9% | 2,670 | Sep 3 | Nov 18 | Twentieth Century Fox |
| 9 | You Again | $25,702,053 | 2,548 | $8,407,513 | 32.7% | 2,548 | Sep 24 | Dec 16 | Walt Disney Studios Motion Pictures |
| 10 | Alpha and Omega | $25,107,267 | 2,625 | $9,106,906 | 36.3% | 2,625 | Sep 17 | Dec 2 | Lionsgate |
| 11 | Going the Distance | $17,804,299 | 3,030 | $6,884,964 | 38.7% | 3,030 | Sep 3 | Oct 21 | Warner Bros. |
| 12 | The Virginity Hit | $636,706 | 700 | $301,885 | 47.4% | 700 | Sep 24 | Oct 7 | Sony Pictures Releasing |
