| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Sorcerer's Apprentice | - | - | - | $2,034,478 | 66 | $2,603,094 | Sep 3 | Walt Disney Pictures | false |
| 2 | Resident Evil: Afterlife | - | - | - | $2,032,950 | 73 | $2,447,898 | Sep 10 | Sony Pictures Releasing | false |
| 3 | The Last Airbender | - | - | - | $1,661,836 | 63 | $2,262,106 | Aug 27 | United International Pictures | false |
| 4 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $1,229,571 | 88 | $1,686,812 | Aug 27 | Warner Bros. | false |
| 5 | Furry Vengeance | - | - | - | $496,636 | 32 | $899,826 | Sep 3 | - | false |
| 6 | Grown Ups | - | - | - | $432,647 | 70 | $2,541,731 | Jul 30 | Sony Pictures Releasing | false |
| 7 | Going the Distance | - | - | - | $396,844 | 40 | $451,433 | Sep 3 | Warner Bros. | false |
| 8 | Brother | - | - | - | $392,621 | 25 | $1,556,003 | Jul 2 | - | false |
| 9 | The Karate Kid | - | - | - | $386,228 | 78 | $2,639,233 | Aug 6 | Sony Pictures Releasing | false |
| 10 | Salt | - | - | - | $374,351 | 62 | $1,017,195 | Aug 20 | Sony Pictures Releasing | false |
| 11 | The Other Guys | - | - | - | $368,457 | 31 | $789,539 | Sep 17 | Sony Pictures Releasing | false |
| 12 | Despicable Me | - | - | - | $355,925 | 83 | $2,321,604 | Aug 13 | United International Pictures | false |
| 13 | Inception | - | - | - | $216,489 | 67 | $1,570,718 | Aug 6 | Warner Bros. | false |
| 14 | Las Caras del Diablo | - | - | - | $105,779 | 15 | $315,079 | Sep 17 | - | false |
| 15 | Taita Boves | - | - | - | $104,617 | 12 | $150,247 | Aug 27 | - | false |
| 16 | Tinker Bell and the Great Fairy Rescue | - | - | - | $62,755 | 15 | $345,335 | Sep 24 | Walt Disney Pictures | false |
| 17 | The Last Song | - | - | - | $51,580 | 12 | $127,211 | Aug 20 | Walt Disney Pictures | false |
| 18 | Shrek Forever After | - | - | - | $41,382 | 87 | $5,984,037 | Jul 9 | United International Pictures | false |
| 19 | Prince of Persia: The Sands of Time | - | - | - | $23,934 | 80 | $2,221,861 | Jul 23 | Walt Disney Pictures | false |
| 20 | El Estudiante 2010 Re-release | - | - | - | $22,034 | 3 | $40,099 | Sep 10 | - | false |
| 21 | Crazy Heart | - | - | - | $19,570 | 3 | $25,971 | Sep 3 | 20th Century Fox International | false |
| 22 | Letters to Juliet | - | - | - | $13,969 | 19 | $156,876 | Jul 30 | - | false |
| 23 | The Burning Plain | - | - | - | $10,551 | 2 | $64,366 | Aug 6 | - | false |
| 24 | Cheila: Una casa pa' Maíta | - | - | - | $7,763 | 15 | $244,505 | Jul 16 | - | false |
| 25 | Toy Story 3 | - | - | - | $6,106 | 95 | $6,339,322 | Jun 18 | Walt Disney Pictures | false |
| 26 | The Magic Flute 2010 Re-release | - | - | - | $3,281 | 2 | $5,688 | Aug 27 | - | false |
