| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Shrek Forever After | - | - | - | $12,080,153 | 793 | $23,451,561 | Aug 25 | United International Pictures | false |
| 2 | Inception | - | - | - | $5,594,770 | 585 | $15,459,083 | Sep 24 | Warner Bros. | false |
| 3 | Resident Evil: Afterlife | - | - | - | $5,460,764 | 308 | $5,253,337 | Sep 10 | Sony Pictures Releasing | false |
| 4 | Vampires Suck | - | - | - | $5,112,710 | 296 | $6,000,711 | Sep 17 | 20th Century Fox International | false |
| 5 | The Solitude of Prime Numbers | - | - | - | $4,318,402 | 371 | $4,928,162 | Sep 10 | Medusa Distribuzione | false |
| 6 | Eat Pray Love | - | - | - | $4,178,108 | 320 | $5,000,639 | Sep 17 | Sony Pictures Releasing | false |
| 7 | The Last Airbender | - | - | - | $4,143,237 | 438 | $7,821,944 | Sep 24 | United International Pictures | false |
| 8 | Law Abiding Citizen | - | - | - | $3,769,520 | 254 | $6,595,412 | Aug 25 | - | false |
| 9 | Sharm el Sheikh - Un'estate indimenticabile | - | - | - | $3,658,149 | 291 | $4,427,419 | Sep 17 | Medusa Distribuzione | false |
| 10 | The Expendables | - | - | - | $3,328,562 | 326 | $4,104,395 | Sep 1 | 01 Distribution | false |
| 11 | Somewhere | - | - | - | $2,589,863 | 240 | $2,783,084 | Sep 3 | Medusa Distribuzione | false |
| 12 | The Karate Kid | - | - | - | $2,496,052 | 363 | $2,569,778 | Sep 3 | Sony Pictures Releasing | false |
| 13 | The Sorcerer's Apprentice | - | - | - | $2,196,584 | 443 | $9,571,490 | Aug 18 | Walt Disney Pictures | false |
| 14 | La passione di Laura | - | - | - | $1,568,136 | 63 | $3,132,470 | Sep 24 | 01 Distribution | false |
| 15 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $1,516,386 | 261 | $1,833,580 | Sep 17 | Warner Bros. | false |
| 16 | The American | - | - | - | $1,477,107 | 277 | $1,482,541 | Sep 10 | United International Pictures | false |
| 17 | A Nightmare on Elm Street | - | - | - | $1,016,484 | 278 | $2,561,703 | Aug 25 | Warner Bros. | false |
| 18 | Leaves of Grass | - | - | - | $899,493 | 136 | $915,051 | Sep 17 | Eagle Pictures | false |
| 19 | Niente paura | - | - | - | $581,170 | 1 | $750,404 | Sep 17 | - | false |
| 20 | Going the Distance | - | - | - | $402,650 | 169 | $403,202 | Sep 3 | Warner Bros. | false |
| 21 | Miral | - | - | - | $235,295 | 57 | $240,435 | Sep 3 | Eagle Pictures | false |
| 22 | 20 Cigarettes | - | - | - | $222,133 | 21 | $332,955 | Sep 10 | Istituto Luce | false |
| 23 | Letters to Juliet | - | - | - | $217,520 | 156 | $821,198 | Aug 25 | Eagle Pictures | false |
| 24 | Howl | - | - | - | $184,474 | 32 | $305,337 | Aug 27 | Fandango | false |
| 25 | London River 2010 Re-release | - | - | - | $176,744 | 39 | $324,215 | Aug 27 | BIM Distribuzione | false |
| 26 | Marmaduke | - | - | - | $127,302 | 297 | $2,503,450 | Aug 13 | 20th Century Fox International | false |
| 27 | North Face | - | - | - | $71,521 | 23 | $132,781 | Aug 27 | - | false |
| 28 | The Secret in Their Eyes | - | - | - | $56,281 | 73 | $1,566,701 | Jun 4 | Lucky Red | false |
| 29 | Resident Evil | - | - | - | $52,865 | 197 | $4,541,400 | Jul 5 | - | false |
| 30 | Dark Love | - | - | - | $51,402 | - | $51,402 | Sep 3 | - | false |
| 31 | The Next Karate Kid | - | - | - | $49,369 | - | $74,376 | Sep 9 | - | false |
| 32 | Wind with the Gone | - | - | - | $44,311 | 1 | $34,429 | Sep 24 | - | false |
| 33 | Basilicata Coast to Coast | - | - | - | $37,882 | 196 | $4,588,816 | Apr 9 | Eagle Pictures | false |
| 34 | Toy Story 3 | - | - | - | $30,597 | 678 | $18,855,881 | Jul 7 | Walt Disney Pictures | false |
| 35 | New Nightmare | - | - | - | $11,279 | 9 | $1,622,522 | Mar 3 | - | false |
| 36 | My Son, My Son, What Have Ye Done | - | - | - | $10,904 | 8 | $67,394 | Sep 10 | - | false |
| 37 | Departures | - | - | - | $9,129 | 42 | $868,327 | Apr 9 | - | false |
