| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Sorcerer's Apprentice | - | - | - | $7,518,853 | 402 | $9,354,968 | Sep 3 | Walt Disney Pictures | false |
| 2 | The Karate Kid | - | - | - | $7,377,401 | 485 | $11,727,245 | Aug 27 | Sony Pictures Releasing | false |
| 3 | Resident Evil: Afterlife | - | - | - | $7,002,927 | 488 | $7,800,947 | Sep 10 | Sony Pictures Releasing | false |
| 4 | Inception | - | - | - | $4,984,576 | 497 | $22,212,764 | Aug 6 | Warner Bros. | false |
| 5 | The Outlaw | - | - | - | $4,185,620 | 310 | $5,040,058 | Sep 3 | 20th Century Fox International | false |
| 6 | You Will Meet a Tall Dark Stranger | - | - | - | $4,033,743 | 252 | $5,960,295 | Aug 27 | Alta Films | false |
| 7 | The American | - | - | - | $3,302,528 | 273 | $4,689,425 | Sep 17 | United International Pictures | false |
| 8 | Salt | - | - | - | $2,796,823 | 446 | $8,022,096 | Aug 20 | Sony Pictures Releasing | false |
| 9 | Eat Pray Love | - | - | - | $2,542,928 | 345 | $6,698,018 | Sep 24 | Sony Pictures Releasing | false |
| 10 | Predators | - | - | - | $2,168,688 | 304 | $3,363,243 | Aug 27 | 20th Century Fox International | false |
| 11 | Toy Story 3 | - | - | - | $1,921,844 | 719 | $33,154,762 | Jul 21 | Walt Disney Pictures | false |
| 12 | Step Up 3D | - | - | - | $1,904,538 | 308 | $2,611,502 | Sep 17 | Walt Disney Pictures | false |
| 13 | Tinker Bell and the Great Fairy Rescue | - | - | - | $1,390,133 | 103 | $2,094,543 | Sep 3 | Walt Disney Pictures | false |
| 14 | The Switch | - | - | - | $1,260,264 | 190 | $1,271,886 | Sep 3 | - | false |
| 15 | Shrek Forever After | - | - | - | $1,249,033 | 761 | $21,928,719 | Jul 8 | Paramount Pictures International | false |
| 16 | The Extraordinary Adventures of Adèle Blanc-Sec | - | - | - | $1,136,415 | 227 | $1,238,875 | Sep 10 | TriPictures | false |
| 17 | Going the Distance | - | - | - | $1,111,669 | 232 | $1,140,210 | Sep 10 | Warner Bros. | false |
| 18 | The Expendables | - | - | - | $1,101,743 | 343 | $6,065,276 | Aug 13 | United International Pictures | false |
| 19 | Centurion | - | - | - | $933,569 | 285 | $3,044,730 | Aug 20 | Aurum Films | false |
| 20 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $895,001 | 336 | $2,710,677 | Aug 20 | Warner Bros. | false |
| 21 | Avatar 2010 Special Edition | - | - | - | $836,037 | 242 | $2,687,307 | Sep 24 | 20th Century Fox International | false |
| 22 | The Last Airbender | - | - | - | $815,056 | 579 | $9,840,134 | Aug 6 | Paramount Pictures International | false |
| 23 | The Great Vazquez | - | - | - | $652,260 | 238 | $1,184,521 | Sep 24 | Alta Films | false |
| 24 | My Afternoons with Margueritte | - | - | - | $515,059 | 57 | $1,030,514 | Aug 20 | Golem Distribución | false |
| 25 | Todo lo que tú quieras | - | - | - | $469,876 | 84 | $559,874 | Sep 10 | Wanda Visión S.A. | false |
| 26 | Get Him to the Greek | - | - | - | $458,143 | 250 | $726,532 | Aug 27 | United International Pictures | false |
| 27 | To Hell with the Ugly | - | - | - | $429,347 | 296 | $9,246,548 | Apr 23 | Warner Bros. | false |
| 28 | The Hole | - | - | - | $405,852 | 220 | $624,075 | Aug 27 | DeAPlaneta | false |
| 29 | Grown Ups | - | - | - | $387,740 | 328 | $8,507,573 | Jul 30 | Sony Pictures Releasing | false |
| 30 | Bright Star | - | - | - | $374,864 | 67 | $416,440 | Sep 3 | Vértigo Films | false |
| 31 | Astro Boy | - | - | - | $292,635 | 141 | $679,352 | Sep 24 | DeAPlaneta | false |
| 32 | Carancho | - | - | - | $247,592 | 52 | $832,546 | Sep 24 | Golem Distribución | false |
| 33 | Mother and Child | - | - | - | $173,250 | 91 | $1,636,486 | Jul 2 | - | false |
| 34 | Undertow | - | - | - | $120,939 | 22 | $215,789 | Sep 17 | Karma Films | false |
| 35 | The Runaways | - | - | - | $107,373 | 57 | $108,756 | Sep 10 | Aurum Films | false |
| 36 | Vision | - | - | - | $99,970 | 16 | $120,016 | Aug 27 | Karma Films | false |
| 37 | Ramona and Beezus | - | - | - | $99,150 | 30 | $161,213 | Sep 17 | 20th Century Fox International | false |
| 38 | Submarino | - | - | - | $82,631 | 16 | $84,684 | Sep 3 | Golem Distribución | false |
| 39 | Killers | - | - | - | $60,849 | 314 | $1,865,795 | Aug 13 | DeAPlaneta | false |
| 40 | Free Rainer 2010 Re-release | - | - | - | $51,629 | 19 | $71,295 | Aug 27 | - | false |
| 41 | Scheherazade, Tell Me a Story | - | - | - | $51,427 | 6 | $172,975 | Jul 2 | Golem Distribución | false |
| 42 | The Secret of Kells | - | - | - | $41,516 | 4 | $62,679 | Aug 20 | Karma Films | false |
| 43 | I Love You Phillip Morris | - | - | - | $39,547 | 235 | $980,060 | Aug 13 | Aurum Films | false |
| 44 | I Am Love | - | - | - | $35,422 | 28 | $586,094 | May 21 | Alta Films | false |
| 45 | The Girlfriend Experience | - | - | - | $33,679 | 6 | $109,851 | Aug 6 | - | false |
| 46 | ¿Dónde se nacionaliza la marea? | - | - | - | $33,169 | 2 | $46,388 | Aug 20 | - | false |
| 47 | Mr. Nobody | - | - | - | $30,876 | 41 | $322,056 | Jul 23 | Wanda Visión S.A. | false |
| 48 | Elisa K | - | - | - | $22,154 | 12 | $48,340 | Sep 24 | Wanda Visión S.A. | false |
| 49 | Blow Horn | - | - | - | $16,214 | 4 | $16,868 | Sep 17 | Karma Films | false |
| 50 | Life During Wartime | - | - | - | $11,687 | 5 | $83,551 | Jul 30 | Golem Distribución | false |
| 51 | Mommy Is at the Hairdresser's | - | - | - | $10,561 | 17 | $68,130 | Jul 30 | - | false |
| 52 | Awaking from a Dream | - | - | - | $9,735 | 10 | $14,340 | Sep 23 | - | false |
| 53 | Hideaway | - | - | - | $7,693 | 4 | $117,067 | Aug 13 | Karma Films | false |
| 54 | 44 Inch Chest 2010 Re-release | - | - | - | $5,615 | 3 | $7,659 | Aug 27 | Aurum Films | false |
| 55 | Maria and I | - | - | - | $5,571 | 14 | $46,394 | Jul 16 | - | false |
| 56 | Dogtooth | - | - | - | $4,978 | 7 | $163,996 | May 14 | Karma Films | false |
| 57 | The Last Station 2010 Re-release | - | - | - | $4,911 | 31 | $450,391 | Jun 11 | Sony Pictures Releasing | false |
| 58 | Change Nothing | - | - | - | $3,293 | 2 | $4,432 | Jun 11 | - | false |
| 59 | Repo Men | - | - | - | $2,868 | 31 | $56,271 | Aug 6 | United International Pictures | false |
| 60 | Nothing Personal | - | - | - | $2,411 | 17 | $263,176 | Jul 9 | Karma Films | false |
| 61 | Sunshine Cleaning | - | - | - | $220 | 36 | $270,421 | Jul 23 | - | false |
