| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Resident Evil: Afterlife | - | - | - | $2,503,744 | 130 | $3,124,133 | Sep 10 | Sony Pictures Releasing | false |
| 2 | The Last Airbender | - | - | - | $1,961,834 | 185 | $3,408,130 | Aug 27 | United International Pictures | false |
| 3 | Inception | - | - | - | $700,651 | 138 | $3,144,672 | Aug 6 | Warner Bros. | false |
| 4 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $338,913 | 146 | $2,094,843 | Aug 13 | Warner Bros. | false |
| 5 | Grown Ups | - | - | - | $246,706 | 50 | $998,569 | Aug 6 | Sony Pictures Releasing | false |
| 6 | Oceans | - | - | - | $245,685 | 37 | $548,608 | Aug 20 | Cine Colombia | false |
| 7 | Going the Distance | - | - | - | $206,896 | 40 | $305,525 | Sep 17 | Warner Bros. | false |
| 8 | Despicable Me | - | - | - | $202,022 | 145 | $297 | Apr 27 | Universal Pictures International (UPI) | false |
| 9 | Wall Street: Money Never Sleeps | - | - | - | $160,603 | 47 | $464,834 | Sep 24 | 20th Century Fox International | false |
| 10 | Vampires Suck | - | - | - | $147,917 | 21 | $246,857 | Sep 3 | 20th Century Fox International | false |
| 11 | Daybreakers | - | - | - | $109,682 | 33 | $132,270 | Sep 3 | Venus | false |
| 12 | Shrek Forever After | - | - | - | $106,095 | 179 | $6,688,109 | Jul 9 | United International Pictures | false |
| 13 | From Paris with Love | - | - | - | $79,683 | 28 | $173,997 | Sep 17 | Babilla Ciné | false |
| 14 | The Box | - | - | - | $65,089 | 23 | $137,384 | Sep 17 | Cine Colombia | false |
| 15 | Halloween II | - | - | - | $56,190 | 22 | $118,926 | Aug 27 | Cine Colombia | false |
| 16 | The Burning Plain | - | - | - | $47,936 | 10 | $68,252 | Sep 17 | Cine Colombia | false |
| 17 | Predators | - | - | - | $47,421 | 62 | $515,270 | Aug 13 | 20th Century Fox International | false |
| 18 | Green Zone 2010 Re-release | - | - | - | $44,674 | 25 | $131,978 | Aug 20 | United International Pictures | false |
| 19 | The Sorcerer's Apprentice | - | - | - | $29,807 | 116 | $2,953,007 | Jul 16 | Walt Disney Pictures | false |
| 20 | Horn of Plenty 2010 Re-release | - | - | - | $26,064 | 16 | $26,064 | Sep 3 | Cineplex | false |
| 21 | Cherry Blossoms | - | - | - | $12,750 | 7 | $123,621 | Jul 9 | Cine Colombia | false |
| 22 | Toy Story 3 | - | - | - | $2,963 | 254 | $10,637,930 | Jun 18 | Walt Disney Pictures | false |
| 23 | Cloud 9 2009 Re-release | - | - | - | $2,347 | 2 | $52,628 | Jul 30 | Cine Colombia | false |
| 24 | Salt | - | - | - | $2,275 | 65 | $823,455 | Jul 23 | Sony Pictures Releasing | false |
| 25 | Two Lovers | - | - | - | $2,154 | 13 | $55,980 | Jun 11 | Cine Colombia | false |
