| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Inception | - | - | - | $810,985 | 72 | $2,562,565 | Aug 12 | Warner Bros. | false |
| 2 | Resident Evil: Afterlife | - | - | - | $747,270 | 73 | $1,353,662 | Sep 15 | Sony Pictures Releasing | false |
| 3 | The Last Airbender | - | - | - | $627,969 | 80 | $1,768,877 | Aug 19 | United International Pictures | false |
| 4 | Grown Ups | - | - | - | $339,730 | 50 | $611,705 | Sep 9 | Sony Pictures Releasing | false |
| 5 | Toy Story 3 | - | - | - | $303,363 | 186 | $8,755,357 | Jun 17 | Walt Disney Pictures | false |
| 6 | Tinker Bell and the Great Fairy Rescue | - | - | - | $227,810 | 22 | $310,178 | Sep 2 | Walt Disney Pictures | false |
| 7 | Avatar 2010 Special Edition | - | - | - | $195,375 | 31 | $208,715 | Sep 2 | 20th Century Fox International | false |
| 8 | Despicable Me | - | - | - | $186,649 | 70 | $1,426,890 | Jul 29 | United International Pictures | false |
| 9 | Going the Distance | - | - | - | $159,734 | 20 | $192,824 | Sep 2 | Warner Bros. | false |
| 10 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $127,114 | 78 | $882,509 | Aug 5 | Warner Bros. | false |
| 11 | Nanny McPhee Returns | - | - | - | $116,253 | 29 | $257,244 | Sep 16 | United International Pictures | false |
| 12 | The Ghost Writer | - | - | - | $107,724 | 13 | $183,642 | Aug 26 | - | false |
| 13 | The Fourth Kind | - | - | - | $90,411 | 16 | $177,219 | Aug 26 | Transeuropa | false |
| 14 | Carriers | - | - | - | $69,368 | 12 | $87,976 | Sep 2 | - | false |
| 15 | Mandrill | - | - | - | $59,395 | 33 | $59,395 | Sep 2 | Andes Films | false |
| 16 | Garfield's Pet Force | - | - | - | $39,805 | 18 | $39,805 | Sep 2 | - | false |
| 17 | Solomon Kane | - | - | - | $36,142 | 7 | $36,142 | Sep 9 | - | false |
| 18 | Brooklyn's Finest 2010 Re-release | - | - | - | $30,128 | 23 | $36,542 | Sep 16 | - | false |
| 19 | The Karate Kid | - | - | - | $20,276 | 47 | $1,135,103 | Jul 22 | Sony Pictures Releasing | false |
| 20 | Brideshead Revisited | - | - | - | $19,168 | 5 | $19,168 | Sep 9 | - | false |
| 21 | Letters to Juliet | - | - | - | $10,448 | 9 | $135,077 | Jul 29 | - | false |
| 22 | Shrek Forever After | - | - | - | $10,127 | 103 | $6,218,841 | Jul 8 | United International Pictures | false |
| 23 | Green Zone 2010 Re-release | - | - | - | $8,874 | 6 | $24,974 | Aug 26 | United International Pictures | false |
| 24 | Brothers | - | - | - | $6,790 | 15 | $56,499 | Aug 19 | - | false |
| 25 | Kick-Ass | - | - | - | $6,535 | 32 | $6,535 | Sep 9 | - | false |
| 26 | The Last Song | - | - | - | $4,861 | 7 | $26,456 | Aug 19 | Walt Disney Pictures | false |
| 27 | Predators | - | - | - | $2,769 | 32 | $402,730 | Jul 29 | 20th Century Fox International | false |
| 28 | The White Ribbon | - | - | - | $1,720 | 7 | $48,591 | Aug 5 | - | false |
| 29 | The Back-up Plan | - | - | - | $178 | 28 | $136,818 | Aug 5 | Sony Pictures Releasing | false |
