| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Gaturro | - | - | - | $1,322,323 | 107 | $533,158 | Sep 9 | Distribution Company | false |
| 2 | Igualita a mí | - | - | - | $1,194,212 | 104 | $3,539,668 | Aug 12 | Walt Disney Pictures | false |
| 3 | The Expendables | - | - | - | $1,181,328 | 74 | $1,290,333 | Sep 2 | Distribution Company | false |
| 4 | The Last Exorcism | - | - | - | $733,037 | 43 | $1,144,364 | Sep 9 | - | false |
| 5 | Eat Pray Love | - | - | - | $629,312 | 55 | $1,367,393 | Sep 16 | Sony Pictures Releasing | false |
| 6 | Inception | - | - | - | $616,382 | 119 | $7,439,087 | Jul 29 | Warner Bros. | false |
| 7 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $549,896 | 112 | $1,415,974 | Aug 19 | Warner Bros. | false |
| 8 | The Last Airbender | - | - | - | $524,688 | 115 | $2,760,838 | Aug 12 | Paramount Pictures International | false |
| 9 | Tinker Bell and the Great Fairy Rescue | - | - | - | $499,642 | 44 | $654,232 | Sep 2 | Walt Disney Pictures | false |
| 10 | The Man Next Door | - | - | - | $384,830 | 35 | $517,540 | Sep 2 | Primer Plano Film Group | false |
| 11 | Going the Distance | - | - | - | $289,205 | 39 | $315,755 | Sep 2 | Warner Bros. | false |
| 12 | Salt | - | - | - | $261,132 | 59 | $562,778 | Aug 26 | Sony Pictures Releasing | false |
| 13 | The Dancer and the Thief | - | - | - | $230,430 | 40 | $261,734 | Sep 9 | Walt Disney Pictures | false |
| 14 | Wall Street: Money Never Sleeps | - | - | - | $225,690 | 57 | $533,972 | Sep 23 | 20th Century Fox International | false |
| 15 | Killers | - | - | - | $197,692 | 32 | $257,923 | Sep 9 | - | false |
| 16 | Avatar 2010 Special Edition | - | - | - | $149,861 | 50 | $572,030 | Sep 23 | 20th Century Fox International | false |
| 17 | Mademoiselle Chambon | - | - | - | $118,490 | 11 | $137,726 | Sep 9 | CDI Films | false |
| 18 | Solitary Man | - | - | - | $108,148 | 21 | $227,969 | Aug 26 | Distribution Company | false |
| 19 | I Love You Phillip Morris | - | - | - | $102,662 | 27 | $345,688 | Sep 23 | - | false |
| 20 | The Hedgehog | - | - | - | $73,857 | 7 | $96,422 | Sep 2 | Impacto Cine | false |
| 21 | El rati horror show | - | - | - | $68,284 | 31 | $74,350 | Sep 16 | Distribution Company | false |
| 22 | Predators | - | - | - | $62,657 | 52 | $553,936 | Aug 12 | 20th Century Fox International | false |
| 23 | Despicable Me | - | - | - | $58,242 | 146 | $2,878,027 | Jul 29 | Universal Pictures International (UPI) | false |
| 24 | Vincere | - | - | - | $45,749 | 20 | $343,189 | Aug 5 | CDI Films | false |
| 25 | The Descent: Part 2 | - | - | - | $44,462 | 39 | $82,547 | Sep 23 | CDI Films | false |
| 26 | Still Walking | - | - | - | $42,174 | 5 | $44,726 | Sep 2 | IFA | false |
| 27 | Lula, the Son of Brazil | - | - | - | $37,482 | 19 | $62,536 | Sep 23 | - | false |
| 28 | Pájaros volando | - | - | - | $36,048 | 44 | $450,678 | Aug 5 | Primer Plano Film Group | false |
| 29 | The Invisible Eye | - | - | - | $20,332 | 12 | $76,158 | Aug 19 | Distribution Company | false |
| 30 | Shrek Forever After | - | - | - | $17,412 | 183 | $13,808,538 | Jul 8 | Paramount Pictures International | false |
| 31 | Yuki and Nina | - | - | - | $14,228 | 7 | $24,500 | Sep 23 | - | false |
| 32 | Chloe | - | - | - | $13,694 | 19 | $160,700 | Aug 12 | Alfa Films | false |
| 33 | Silent Light 2010 Re-release | - | - | - | $9,919 | 4 | $25,956 | Aug 26 | Impacto Cine | false |
| 34 | The Boys Are Back | - | - | - | $9,212 | 17 | $40,985 | Aug 26 | Alfa Films | false |
| 35 | My Days with Gloria | - | - | - | $8,107 | 16 | $8,434 | Sep 16 | - | false |
| 36 | The Sorcerer's Apprentice | - | - | - | $7,404 | 87 | $3,129,367 | Jul 15 | Walt Disney Pictures | false |
| 37 | London River 2010 Re-release | - | - | - | $6,970 | 17 | $77,714 | Aug 19 | Primer Plano Film Group | false |
| 38 | Fish Tank | - | - | - | $6,592 | 5 | $6,592 | Sep 16 | - | false |
| 39 | Hot Tub Time Machine | - | - | - | $6,314 | 27 | $118,847 | Aug 5 | - | false |
| 40 | I Hate Valentine's Day | - | - | - | $5,212 | 9 | $52,685 | Jul 29 | Impacto Cine | false |
| 41 | Miss Tacuarembó | - | - | - | $3,152 | 58 | $159,421 | Jul 15 | - | false |
| 42 | Jungle Tales | - | - | - | $2,209 | 47 | $76,857 | Jul 22 | Primer Plano Film Group | false |
| 43 | Neither God, Nor Master or Husband | - | - | - | $2,196 | 5 | $3,422 | Sep 23 | Primer Plano Film Group | false |
| 44 | Carriers | - | - | - | $2,186 | 26 | $184,432 | Jul 22 | Distribution Company | false |
| 45 | Letters to Juliet | - | - | - | $1,960 | 17 | $398,187 | Jun 10 | Alfa Films | false |
| 46 | Rembrandt's J'Accuse | - | - | - | $1,883 | 2 | $1,883 | Sep 16 | - | false |
| 47 | Leaving | - | - | - | $1,828 | 14 | $123,433 | Jul 22 | Alfa Films | false |
| 48 | The Girl Who Played with Fire | - | - | - | $1,391 | 7 | $67,286 | Aug 5 | - | false |
| 49 | Five Minutes of Heaven | - | - | - | $1,172 | 20 | $51,698 | Aug 5 | Distribution Company | false |
| 50 | The Ghost Writer | - | - | - | $805 | 42 | $789,829 | May 13 | Alfa Films | false |
| 51 | Little Girl | - | - | - | $794 | 8 | $118,507 | Jul 8 | - | false |
| 52 | Knight and Day Original Release | - | - | - | $492 | 75 | $1,000,206 | Jul 15 | 20th Century Fox International | false |
| 53 | Wild Grass | - | - | - | $484 | 4 | $97,911 | Jul 15 | Alfa Films | false |
| 54 | Hansel and Gretel 2010 Re-release | - | - | - | $387 | 8 | $11,511 | Aug 26 | Impacto Cine | false |
| 55 | The Twilight Saga: Eclipse | - | - | - | $199 | 120 | $4,373,158 | Jul 1 | Alfa Films | false |
| 56 | The A-Team | - | - | - | $122 | 60 | $325,161 | Jun 24 | 20th Century Fox International | false |
