| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Up | - | - | - | $150,182 | 10 | $224,274 | Aug 28 | Walt Disney Pictures | false |
| 2 | Inglourious Basterds | - | - | - | $137,357 | 5 | $226,081 | Aug 26 | United International Pictures | false |
| 3 | The Ugly Truth | - | - | - | $103,265 | 5 | $144,517 | Sep 18 | Sony Pictures Releasing | false |
| 4 | District 9 | - | - | - | $68,581 | 4 | $92,214 | Sep 18 | - | false |
| 5 | The Big Rescue | - | - | - | $66,527 | 8 | $211,833 | Sep 25 | - | false |
| 6 | The Girl with the Dragon Tattoo | - | - | - | $60,972 | 4 | $337,563 | Jul 22 | - | false |
| 7 | The Final Destination | - | - | - | $60,855 | 4 | $61,958 | Sep 11 | - | false |
| 8 | Reykjavik Whale Watching Massacre | - | - | - | $43,291 | 5 | $43,476 | Sep 4 | - | false |
| 9 | The Proposal | - | - | - | $19,487 | 6 | $229,159 | Jul 29 | Walt Disney Pictures | false |
| 10 | Funny People | - | - | - | $19,440 | 3 | $41,729 | Sep 25 | United International Pictures | false |
| 11 | Drag Me to Hell | - | - | - | $16,481 | 3 | $70,994 | Aug 19 | - | false |
| 12 | The Taking of Pelham 123 | - | - | - | $13,422 | 4 | $40,609 | Aug 19 | Sony Pictures Releasing | false |
| 13 | Bandslam | - | - | - | $13,005 | 3 | $14,701 | Sep 11 | - | false |
| 14 | Halloween II | - | - | - | $12,334 | 2 | $12,334 | Sep 4 | - | false |
| 15 | Ice Age: Dawn of the Dinosaurs | - | - | - | $11,133 | 14 | $277,222 | Jul 1 | 20th Century Fox International | false |
| 16 | G-Force | - | - | - | $10,214 | 5 | $121,676 | Aug 7 | Walt Disney Pictures | false |
| 17 | Jennifer's Body | - | - | - | $9,534 | 3 | $16,653 | Sep 25 | 20th Century Fox International | false |
| 18 | Beyond a Reasonable Doubt | - | - | - | $8,554 | 2 | $8,709 | Sep 11 | - | false |
| 19 | G.I. Joe: The Rise of Cobra | - | - | - | $6,031 | 5 | $75,827 | Aug 12 | United International Pictures | false |
| 20 | Harry Potter and the Half-Blood Prince | - | - | - | $5,989 | 8 | $326,528 | Jul 15 | Warner Bros. | false |
| 21 | The September Issue | - | - | - | $5,964 | 1 | $5,964 | Sep 4 | - | false |
| 22 | The Goods: Live Hard, Sell Hard | - | - | - | $5,654 | 2 | $19,895 | Aug 19 | - | false |
| 23 | The Haunting in Connecticut | - | - | - | $4,828 | 2 | $10,775 | Sep 25 | - | false |
| 24 | Public Enemies | - | - | - | $2,908 | 5 | $141,273 | Aug 5 | United International Pictures | false |
| 25 | The Time Traveler's Wife | - | - | - | $2,597 | 2 | $14,593 | Aug 19 | - | false |
| 26 | My Sister's Keeper | - | - | - | $2,087 | 3 | $92,493 | Jul 8 | - | false |
| 27 | Bionicle: The Legend Reborn | - | - | - | $1,997 | 5 | $4,883 | Sep 25 | - | false |
