| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Final Destination | - | - | - | $14,076,917 | 427 | $20,174,471 | Aug 28 | Entertainment Film Distributors | false |
| 2 | District 9 | - | - | - | $12,507,286 | 453 | $14,511,508 | Sep 4 | Sony Pictures Releasing | false |
| 3 | 500 Days of Summer | - | - | - | $6,815,082 | 324 | $7,596,857 | Sep 4 | 20th Century Fox International | false |
| 4 | Cloudy with a Chance of Meatballs | - | - | - | $5,987,228 | 438 | $10,330,809 | Sep 18 | Sony Pictures Releasing | false |
| 5 | Fame | - | - | - | $5,839,069 | 460 | $14,308,999 | Sep 25 | Entertainment Film Distributors | false |
| 6 | Inglourious Basterds | - | - | - | $5,652,610 | 445 | $16,439,434 | Aug 21 | Universal Pictures International (UPI) | false |
| 7 | Dorian Gray | - | - | - | $4,025,747 | 349 | $4,700,705 | Sep 11 | Momentum Pictures | false |
| 8 | Funny People | - | - | - | $3,947,425 | 382 | $5,575,738 | Aug 28 | Universal Pictures International (UPI) | false |
| 9 | Harry Potter and the Half-Blood Prince | - | - | - | $3,720,970 | 586 | $65,609,036 | Jul 17 | Warner Bros. | false |
| 10 | Julie & Julia | - | - | - | $3,520,936 | 359 | $3,996,292 | Sep 11 | Sony Pictures Releasing | false |
| 11 | The Time Traveler's Wife | - | - | - | $3,016,356 | 431 | $12,171,979 | Aug 14 | Entertainment Film Distributors | false |
| 12 | Aliens in the Attic | - | - | - | $2,978,671 | 457 | $10,498,970 | Aug 7 | 20th Century Fox International | false |
| 13 | Sorority Row | - | - | - | $2,910,442 | 349 | $2,910,442 | Sep 11 | Entertainment One | false |
| 14 | G-Force | - | - | - | $2,479,189 | 468 | $22,011,541 | Jul 31 | Walt Disney Pictures | false |
| 15 | Surrogates | - | - | - | $2,426,566 | 360 | $4,940,897 | Sep 25 | Walt Disney Pictures | false |
| 16 | Gamer | - | - | - | $1,883,440 | 346 | $1,883,440 | Sep 18 | Entertainment Film Distributors | false |
| 17 | Ice Age: Dawn of the Dinosaurs | - | - | - | $1,247,386 | 526 | $56,859,040 | Jul 1 | 20th Century Fox International | false |
| 18 | The Firm | - | - | - | $1,094,777 | 265 | $1,094,777 | Sep 18 | Warner Bros. | false |
| 19 | The Soloist | - | - | - | $1,033,429 | 351 | $1,679,198 | Sep 11 | Universal Pictures International (UPI) | false |
| 20 | G.I. Joe: The Rise of Cobra | - | - | - | $806,570 | 442 | $10,313,105 | Aug 7 | Paramount Pictures International | false |
| 21 | The Hurt Locker | - | - | - | $800,002 | 141 | $1,302,388 | Aug 28 | Optimum Releasing | false |
| 22 | Adventureland | - | - | - | $796,548 | 204 | $796,548 | Sep 11 | Walt Disney Pictures | false |
| 23 | Broken Embraces | - | - | - | $739,404 | 93 | $1,220,908 | Aug 28 | Warner Bros. | false |
| 24 | The Ugly Truth | - | - | - | $620,812 | 400 | $10,358,259 | Aug 7 | Sony Pictures Releasing | false |
| 25 | Creation | - | - | - | $611,721 | 236 | $1,160,359 | Sep 25 | Icon Film Distribution Australia | false |
| 26 | The Proposal | - | - | - | $468,145 | 441 | $19,239,235 | Aug 7 | Walt Disney Pictures | false |
| 27 | Away We Go | - | - | - | $407,006 | 152 | $407,006 | Sep 18 | Entertainment One | false |
| 28 | Whiteout | - | - | - | $251,470 | 264 | $251,470 | Sep 11 | Optimum Releasing | false |
| 29 | Dil Bole Hadippa | - | - | - | $224,785 | 34 | $224,785 | Sep 18 | Yash Raj Films | false |
| 30 | Fish Tank | - | - | - | $171,838 | 47 | $171,838 | Sep 11 | Artificial Eye | false |
