| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Orphan | - | - | - | $431,560 | 25 | $722,045 | Aug 27 | Warner Bros. | false |
| 2 | Cloudy with a Chance of Meatballs | - | - | - | $381,204 | 50 | $1,044,266 | Sep 16 | Sony Pictures Releasing | false |
| 3 | The Taking of Pelham 123 | - | - | - | $296,861 | 33 | $401,304 | Sep 10 | Sony Pictures Releasing | false |
| 4 | The Ugly Truth | - | - | - | $269,749 | 25 | $370,726 | Sep 3 | Sony Pictures Releasing | false |
| 5 | Dawson Isla 10 | - | - | - | $265,738 | 21 | $433,603 | Sep 10 | - | false |
| 6 | The Hangover | - | - | - | $253,893 | 29 | $586,310 | Aug 20 | Warner Bros. | false |
| 7 | Tinker Bell and the Lost Treasure | - | - | - | $210,398 | 33 | $245,475 | Sep 3 | Walt Disney Pictures | false |
| 8 | Aliens in the Attic | - | - | - | $185,708 | 32 | $302,418 | Aug 27 | 20th Century Fox International | false |
| 9 | G-Force | - | - | - | $139,872 | 48 | $1,595,232 | Jul 23 | Walt Disney Pictures | false |
| 10 | The Maid | - | - | - | $118,057 | 20 | $429,657 | Aug 13 | Andes Films | false |
| 11 | Last Chance Harvey | - | - | - | $89,567 | 12 | $158,660 | Aug 27 | - | false |
| 12 | Boogeyman 2 | - | - | - | $65,315 | 15 | $67,452 | Sep 3 | - | false |
| 13 | Ice Age: Dawn of the Dinosaurs | - | - | - | $45,920 | 89 | $7,125,445 | Jul 2 | 20th Century Fox International | false |
| 14 | The Time Traveler's Wife | - | - | - | $40,019 | 7 | $56,630 | Sep 10 | Warner Bros. | false |
| 15 | The Proposal | - | - | - | $32,946 | 29 | $293,813 | Aug 6 | Walt Disney Pictures | false |
| 16 | My Sister's Keeper | - | - | - | $28,925 | 9 | $96,815 | Sep 24 | Warner Bros. | false |
| 17 | New in Town | - | - | - | $28,447 | 8 | $32,045 | Sep 10 | - | false |
| 18 | Public Enemies | - | - | - | $26,912 | 35 | $497,563 | Jul 30 | United International Pictures | false |
| 19 | Shorts | - | - | - | $23,823 | 32 | $230,695 | Aug 6 | Warner Bros. | false |
| 20 | Che: Part Two | - | - | - | $23,292 | 7 | $24,244 | Sep 3 | - | false |
| 21 | My Bloody Valentine | - | - | - | $22,529 | 27 | $103,629 | Aug 20 | - | false |
| 22 | Transporter 3 | - | - | - | $21,683 | 10 | $39,041 | Aug 27 | - | false |
| 23 | The Visitor | - | - | - | $16,794 | 4 | $16,794 | Sep 3 | - | false |
| 24 | Lorna's Silence | - | - | - | $14,349 | 3 | $18,181 | Sep 17 | - | false |
| 25 | Bangkok Dangerous | - | - | - | $12,814 | 17 | $86,710 | Aug 13 | - | false |
| 26 | The Class | - | - | - | $10,507 | 2 | $15,673 | Sep 17 | - | false |
| 27 | G.I. Joe: The Rise of Cobra | - | - | - | $9,814 | 54 | $420,139 | Aug 6 | United International Pictures | false |
| 28 | State of Play | - | - | - | $6,082 | 23 | $80,637 | Aug 13 | United International Pictures | false |
| 29 | Goodbye Bafana | - | - | - | $5,382 | 4 | $5,382 | Sep 24 | - | false |
| 30 | The Edge of Heaven | - | - | - | $4,615 | 3 | $4,615 | Sep 10 | Transeuropa | false |
