| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Up | - | - | - | $8,669,348 | 329 | $10,528,510 | Sep 4 | Walt Disney Pictures | false |
| 2 | So Normal 2: The Craziest Night Ever | - | - | - | $7,033,956 | 437 | $10,747,823 | Aug 28 | - | false |
| 3 | The Hangover | - | - | - | $3,790,834 | 214 | $8,911,937 | Aug 21 | Warner Bros. | false |
| 4 | The Taking of Pelham 123 | - | - | - | $3,500,711 | 181 | $4,246,493 | Sep 4 | Sony Pictures Releasing | false |
| 5 | The Ugly Truth | - | - | - | $2,660,774 | 164 | $7,286,581 | Sep 18 | Sony Pictures Releasing | false |
| 6 | Ice Age: Dawn of the Dinosaurs | - | - | - | $1,151,591 | 710 | $45,373,371 | Jul 1 | 20th Century Fox International | false |
| 7 | My Sister's Keeper | - | - | - | $916,597 | 94 | $1,175,619 | Sep 11 | PlayArte Pictures | false |
| 8 | G-Force | - | - | - | $912,477 | 304 | $4,411,008 | Aug 14 | Walt Disney Pictures | false |
| 9 | My Life in Ruins | - | - | - | $749,654 | 121 | $812,423 | Sep 11 | - | false |
| 10 | Orphan | - | - | - | $682,845 | 81 | $814,780 | Sep 4 | Warner Bros. | false |
| 11 | Two Lovers | - | - | - | $423,940 | 50 | $667,097 | Aug 28 | PlayArte Pictures | false |
| 12 | Drag Me to Hell | - | - | - | $351,158 | 194 | $1,790,906 | Aug 14 | Universal Pictures International (UPI) | false |
| 13 | The Proposal | - | - | - | $340,466 | 159 | $7,438,656 | Jul 10 | Walt Disney Pictures | false |
| 14 | The Invisible Woman | - | - | - | $326,674 | 221 | $11,436,322 | Jun 5 | Warner Bros. | false |
| 15 | G.I. Joe: The Rise of Cobra | - | - | - | $292,908 | 369 | $3,517,203 | Aug 7 | Paramount Pictures International | false |
| 16 | Harry Potter and the Half-Blood Prince | - | - | - | $249,909 | 702 | $20,240,271 | Jul 17 | Warner Bros. | false |
| 17 | Aliens in the Attic | - | - | - | $245,876 | 84 | $493,214 | Sep 25 | 20th Century Fox International | false |
| 18 | Spread | - | - | - | $213,498 | 52 | $602,656 | Sep 25 | - | false |
| 19 | Brüno | - | - | - | $196,606 | 89 | $1,170,855 | Aug 14 | Sony Pictures Releasing | false |
| 20 | Sorority Row | - | - | - | $194,123 | 80 | $297,916 | Sep 25 | Paris Filmes | false |
| 21 | Hannah Montana: The Movie | - | - | - | $187,389 | 196 | $2,796,536 | Jun 11 | Walt Disney Pictures | false |
| 22 | Shorts | - | - | - | $159,908 | 61 | $287,452 | Aug 28 | Warner Bros. | false |
| 23 | Bandslam | - | - | - | $134,185 | 82 | $144,436 | Sep 11 | Paris Filmes | false |
| 24 | Antichrist | - | - | - | $130,833 | 14 | $198,098 | Aug 28 | - | false |
| 25 | The Story of Me | - | - | - | $99,720 | 95 | $592,924 | Aug 7 | Warner Bros. | false |
| 26 | Time of Peace | - | - | - | $99,152 | 53 | $428,328 | Aug 14 | - | false |
| 27 | The Wave | - | - | - | $81,928 | 17 | $142,635 | Aug 21 | - | false |
| 28 | Adrift | - | - | - | $76,380 | 42 | $471,448 | Jul 31 | Universal Pictures International (UPI) | false |
| 29 | Che: Part Two | - | - | - | $62,668 | 34 | $102,281 | Sep 18 | Europa Filmes | false |
| 30 | Doomsday | - | - | - | $50,305 | 66 | $184,371 | Aug 21 | Europa Filmes | false |
| 31 | Diary of a Nymphomaniac | - | - | - | $41,222 | 34 | $47,714 | Sep 25 | PlayArte Pictures | false |
| 32 | The Wedding Song | - | - | - | $36,330 | 15 | $36,330 | Sep 4 | Paris Filmes | false |
| 33 | Last Chance Harvey | - | - | - | $29,221 | 31 | $791,723 | Jun 19 | - | false |
| 34 | Giant | - | - | - | $23,077 | 12 | $59,261 | Aug 21 | - | false |
| 35 | Veronika Decides to Die | - | - | - | $22,485 | 61 | $170,702 | Aug 21 | - | false |
| 36 | Departures | - | - | - | $19,050 | 21 | $394,224 | Jun 5 | Paris Filmes | false |
| 37 | The Butterfly Effect 3: Revelations | - | - | - | $16,670 | 80 | $606,118 | Jul 31 | - | false |
| 38 | Halloween | - | - | - | $7,349 | 104 | $732,949 | Jul 24 | PlayArte Pictures | false |
| 39 | The Accidental Husband | - | - | - | $6,613 | 121 | $1,056,833 | Aug 7 | PlayArte Pictures | false |
| 40 | The International | - | - | - | $6,053 | 51 | $625,835 | Jun 19 | Sony Pictures Releasing | false |
| 41 | The Milk of Sorrow | - | - | - | $1,719 | 19 | $33,007 | Aug 21 | Paris Filmes | false |
| 42 | 17 Again | - | - | - | $1,446 | 147 | $1,326,781 | Jul 10 | PlayArte Pictures | false |
| 43 | Frozen River | - | - | - | $506 | 6 | $49,510 | Feb 20 | Sony Pictures Releasing | false |
| 44 | Waltz with Bashir | - | - | - | $425 | 9 | $111,235 | Apr 3 | Sony Pictures Releasing | false |
| 45 | The Girlfriend Experience | - | - | - | $412 | 26 | $54,474 | Aug 14 | Paris Filmes | false |
| 46 | Angels & Demons | - | - | - | $382 | 509 | $13,858,975 | May 15 | Sony Pictures Releasing | false |
| 47 | The Assailant | - | - | - | $271 | 145 | $2,019,443 | Oct 30 | Walt Disney Pictures | false |
